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5AHN

IMP-bound form of the D199N mutant of IMPDH from Pseudomonas aeruginosa

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003824molecular_functioncatalytic activity
A0003938molecular_functionIMP dehydrogenase activity
A0005524molecular_functionATP binding
A0006164biological_processpurine nucleotide biosynthetic process
A0006177biological_processGMP biosynthetic process
A0006183biological_processGTP biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0042802molecular_functionidentical protein binding
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues16
DetailsBINDING SITE FOR RESIDUE IMP A 1468
ChainResidue
AALA47
ASER361
AHOH2089
AHOH2253
AHOH2270
AHOH2271
AHOH2272
AHOH2280
AMET49
AGLY301
ASER302
AASP337
AGLY339
AMET358
AMET359
AGLY360

site_idAC2
Number of Residues8
DetailsBINDING SITE FOR RESIDUE MG A 1469
ChainResidue
AGLU54
AMG1470
AHOH2094
AHOH2101
AHOH2102
AHOH2336
AHOH2337
AHOH2338

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 1470
ChainResidue
AMG1469
AHOH2101
AHOH2102
AHOH2197
AHOH2337
AHOH2338
AHOH2339

Functional Information from PROSITE/UniProt
site_idPS00487
Number of Residues13
DetailsIMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. VKVGIGpGSICtT
ChainResidueDetails
AVAL294-THR306

245663

PDB entries from 2025-12-03

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