5AGV
The sliding clamp of Mycobacterium tuberculosis in complex with a natural product.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006260 | biological_process | DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006260 | biological_process | DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 501 |
| Chain | Residue |
| A | THR389 |
| A | BU3508 |
| A | HOH823 |
| A | HOH832 |
| A | HOH849 |
| A | HOH897 |
| A | HOH917 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 502 |
| Chain | Residue |
| A | HOH762 |
| A | HOH803 |
| A | HIS269 |
| A | HOH702 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 503 |
| Chain | Residue |
| A | ASP292 |
| A | HOH687 |
| A | HOH916 |
| A | HOH967 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | binding site for residue NA A 504 |
| Chain | Residue |
| A | SER249 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 505 |
| Chain | Residue |
| A | LEU240 |
| A | ILE242 |
| A | SER249 |
| A | THR250 |
| A | THR251 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | binding site for residue NA A 506 |
| Chain | Residue |
| A | ARG84 |
| A | LEU85 |
| A | ASP88 |
| A | HOH1019 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 507 |
| Chain | Residue |
| A | THR120 |
| A | HOH691 |
| A | HOH889 |
| A | HOH942 |
| A | HOH950 |
| A | HOH1036 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | binding site for residue BU3 A 508 |
| Chain | Residue |
| A | VAL188 |
| A | GLU190 |
| A | THR389 |
| A | ASP390 |
| A | TYR391 |
| A | CA501 |
| A | HOH666 |
| A | HOH823 |
| A | HOH832 |
| A | HOH849 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue BU3 A 509 |
| Chain | Residue |
| A | ALA214 |
| A | GLY218 |
| A | GLY244 |
| A | ASN245 |
| A | LYS247 |
| A | HOH655 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue BU3 A 510 |
| Chain | Residue |
| A | ARG16 |
| A | GLU72 |
| A | HOH748 |
| B | ARG16 |
| B | LEU17 |
| B | GLU72 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 501 |
| Chain | Residue |
| A | GLY220 |
| A | GLY221 |
| A | HOH624 |
| B | GLU142 |
| B | HOH768 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 502 |
| Chain | Residue |
| B | NA507 |
| B | HOH670 |
| B | HOH765 |
| B | HOH977 |
| B | HOH987 |
| B | HOH1078 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 503 |
| Chain | Residue |
| B | THR389 |
| B | BU3513 |
| B | HOH762 |
| B | HOH862 |
| B | HOH879 |
| B | HOH961 |
| B | HOH968 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 504 |
| Chain | Residue |
| B | ASN379 |
| B | GLY380 |
| B | HOH710 |
| B | HOH776 |
| B | HOH801 |
| B | HOH836 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 505 |
| Chain | Residue |
| B | LEU33 |
| B | ALA35 |
| B | BU3512 |
| B | HOH636 |
| B | HOH682 |
| B | HOH741 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 506 |
| Chain | Residue |
| B | ARG366 |
| B | VAL387 |
| B | HOH802 |
| B | HOH830 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 507 |
| Chain | Residue |
| B | ASP325 |
| B | TYR326 |
| B | CA502 |
| B | HOH977 |
| B | HOH987 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 508 |
| Chain | Residue |
| B | SER21 |
| B | ASP24 |
| B | VAL69 |
| B | HOH627 |
| B | HOH780 |
| B | HOH950 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue NA B 509 |
| Chain | Residue |
| B | SER57 |
| B | GLU66 |
| B | HOH808 |
| B | HOH996 |
| B | THR55 |
| site_id | AE2 |
| Number of Residues | 4 |
| Details | binding site for residue NA B 510 |
| Chain | Residue |
| B | GLY294 |
| B | ASN336 |
| B | THR338 |
| B | HOH1020 |
| site_id | AE3 |
| Number of Residues | 1 |
| Details | binding site for residue NA B 511 |
| Chain | Residue |
| B | GLU282 |
| site_id | AE4 |
| Number of Residues | 8 |
| Details | binding site for residue BU3 B 512 |
| Chain | Residue |
| B | LEU33 |
| B | GLY44 |
| B | VAL45 |
| B | CA505 |
| B | HOH628 |
| B | HOH636 |
| B | HOH669 |
| B | HOH682 |
| site_id | AE5 |
| Number of Residues | 11 |
| Details | binding site for residue BU3 B 513 |
| Chain | Residue |
| B | VAL188 |
| B | GLU190 |
| B | ARG262 |
| B | THR389 |
| B | ASP390 |
| B | TYR391 |
| B | CA503 |
| B | HOH762 |
| B | HOH767 |
| B | HOH862 |
| B | HOH879 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide MLU C 10 and GLY C 11 |
| Chain | Residue |
| A | ARG183 |
| C | NZC4 |
| C | LEU5 |
| C | LEU7 |
| C | PH69 |
| D | MLU10 |
| site_id | AE7 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide MLU D 10 and GLY D 11 |
| Chain | Residue |
| B | ARG183 |
| C | MLU10 |
| D | NZC4 |
| D | LEU5 |
| D | LEU7 |
| D | PH69 |
