5AGU
The sliding clamp of Mycobacterium tuberculosis in complex with a natural product.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006260 | biological_process | DNA replication |
| A | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| A | 0008408 | molecular_function | 3'-5' exonuclease activity |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0009360 | cellular_component | DNA polymerase III complex |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0071897 | biological_process | DNA biosynthetic process |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006260 | biological_process | DNA replication |
| B | 0006271 | biological_process | DNA strand elongation involved in DNA replication |
| B | 0008408 | molecular_function | 3'-5' exonuclease activity |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0009360 | cellular_component | DNA polymerase III complex |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046677 | biological_process | response to antibiotic |
| B | 0071897 | biological_process | DNA biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MLU C 10 |
| Chain | Residue |
| A | ARG183 |
| A | SER194 |
| A | HOH2111 |
| C | LEU7 |
| C | PRO9 |
| C | GLY11 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE BU3 A 1403 |
| Chain | Residue |
| A | ALA195 |
| A | SER196 |
| A | ARG225 |
| A | HOH2116 |
| A | GLU135 |
| A | THR160 |
| A | SER194 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TRS A 1404 |
| Chain | Residue |
| A | VAL188 |
| A | GLU190 |
| A | THR389 |
| A | ASP390 |
| A | TYR391 |
| B | ASP199 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | Binding site for residues ACE C 1 and MVA C 2 |
| Chain | Residue |
| A | GLU142 |
| A | SER222 |
| A | VAL398 |
| A | ARG399 |
| A | HOH2131 |
| A | HOH2222 |
| C | MP83 |
| C | NZC4 |
| site_id | AC5 |
| Number of Residues | 9 |
| Details | Binding site for residues MVA C 2 and MP8 C 3 |
| Chain | Residue |
| A | GLU142 |
| A | PHE184 |
| A | SER222 |
| A | MET396 |
| A | PRO397 |
| A | HOH2131 |
| A | HOH2221 |
| C | ACE1 |
| C | NZC4 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | Binding site for residues MP8 C 3 and NZC C 4 |
| Chain | Residue |
| A | ARG183 |
| A | PHE184 |
| A | MET396 |
| A | PRO397 |
| A | HOH2221 |
| A | HOH2226 |
| C | ACE1 |
| C | MVA2 |
| C | LEU5 |
| C | GLY11 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | Binding site for residues ACE D 1 and MVA D 2 |
| Chain | Residue |
| B | PHE184 |
| B | VAL398 |
| B | ARG399 |
| D | MP83 |
| D | NZC4 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | Binding site for residues MVA D 2 and MP8 D 3 |
| Chain | Residue |
| B | PHE184 |
| B | MET396 |
| B | PRO397 |
| B | ARG399 |
| B | HOH2128 |
| D | ACE1 |
| D | NZC4 |
| site_id | AC9 |
| Number of Residues | 10 |
| Details | Binding site for residues MP8 D 3 and NZC D 4 |
| Chain | Residue |
| B | ARG183 |
| B | PHE184 |
| B | MET396 |
| B | PRO397 |
| B | ARG399 |
| B | HOH2128 |
| D | ACE1 |
| D | MVA2 |
| D | LEU5 |
| D | GLY11 |
