5AG3

Chorismatase mechanisms reveal fundamentally different types of reaction in a single conserved protein fold

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016829	molecular_function	lyase activity
A	0016833	molecular_function	oxo-acid-lyase activity
B	0016829	molecular_function	lyase activity
B	0016833	molecular_function	oxo-acid-lyase activity
C	0016829	molecular_function	lyase activity
C	0016833	molecular_function	oxo-acid-lyase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 3EB A 1341

Chain	Residue
A	TYR147
A	HOH2113
A	HOH2129
A	ARG154
A	ALA171
A	GLY173
A	TYR207
A	PHE218
A	ARG220
A	GLY240
A	CYS327

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 3EB B 1341

Chain	Residue
B	TYR147
B	ARG154
B	ALA171
B	GLY173
B	TYR207
B	PHE218
B	ARG220
B	GLY240
B	CYS327
B	HOH2107

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1341

Chain	Residue
C	SER38
C	VAL39
C	CYS40
C	ASN55
C	GLY178
C	GLY179
C	PEG1343

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 C 1342

Chain	Residue
A	ARG260
C	PRO213
C	ARG214
C	ALA215
C	ARG217
C	HOH2157
C	HOH2158

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 B 1342

Chain	Residue
B	PRO213
B	ARG214
B	ALA215
B	ARG217

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 1342

Chain	Residue
A	ARG152
A	PRO213

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 1343

Chain	Residue
A	LYS209
A	PRO213
A	ARG214
A	ALA215
A	ARG217
B	PEG1344

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG B 1343

Chain	Residue
B	ARG260
B	HOH2183
C	ASP139

---

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PEG C 1343

Chain	Residue
C	ARG177
C	SO41341
C	HOH2146

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG C 1344

Chain	Residue
C	ARG310
C	HOH2078

---

site_id	BC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PEG C 1345

Chain	Residue
C	ASN17
C	GLY18
C	ARG19
C	TYR42
C	GLU62
C	PRO63
C	HOH2045
C	HOH2212

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG B 1344

Chain	Residue
A	SO41343
B	ASN9

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1345

Chain	Residue
A	GLY272
A	GLY273
A	ALA276
A	SER281
A	ALA282
A	GLY283

---

site_id	BC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PEG A 1346

Chain	Residue
A	HOH2195

---

site_id	BC6
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PEG A 1347

Chain	Residue
A	ASN17
A	ARG306
A	ILE319
A	HOH2196

---

site_id	BC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG C 1346

Chain	Residue
C	GLY18
C	ARG21
C	VAL22
C	HIS47
C	TYR49
C	HOH2015
C	HOH2055

---

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE PEG A 1348

Chain	Residue
A	ARG148
A	HOH2197

---

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PEG A 1349

Chain	Residue
A	ALA58
A	ASP80
A	ALA109
A	VAL112
A	THR113
A	GLU116
A	HOH2069

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PEG A 1350

Chain	Residue
A	LEU11
A	THR12
A	GLN235
A	HOH2001
A	HOH2198
B	HOH2116

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:26247872

Chain	Residue	Details
A	GLU334
B	GLU334
C	GLU334

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:26247872

Chain	Residue	Details
A	TYR147
A	ARG154
A	TYR207
A	ARG220
B	TYR147
B	ARG154
B	TYR207
B	ARG220
C	TYR147
C	ARG154
C	TYR207
C	ARG220

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	SITE: Important for product selectivity => ECO:0000269|PubMed:26247872

Chain	Residue	Details
A	GLY240
A	CYS327
B	GLY240
B	CYS327
C	GLY240
C	CYS327

---