5AFX
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| A | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| A | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004161 | molecular_function | dimethylallyltranstransferase activity |
| B | 0004337 | molecular_function | (2E,6E)-farnesyl diphosphate synthase activity |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0045337 | biological_process | farnesyl diphosphate biosynthetic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1368 |
| Chain | Residue |
| A | ASP255 |
| A | ASP259 |
| A | PVZ1371 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG A 1369 |
| Chain | Residue |
| A | ASP103 |
| A | ASP107 |
| A | PVZ1371 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 1370 |
| Chain | Residue |
| A | PVZ1371 |
| A | ASP103 |
| A | ASP107 |
| A | GLN172 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG B 1368 |
| Chain | Residue |
| B | ASP255 |
| B | ASP259 |
| B | PVZ1371 |
| B | HOH2062 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1369 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | PVZ1371 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1370 |
| Chain | Residue |
| B | ASP103 |
| B | ASP107 |
| B | GLN172 |
| B | ASP175 |
| B | PVZ1371 |
| B | HOH2032 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE PVZ A 1371 |
| Chain | Residue |
| A | TYR99 |
| A | LEU100 |
| A | ASP103 |
| A | MET106 |
| A | ASP107 |
| A | ARG112 |
| A | ASP165 |
| A | ALA169 |
| A | GLN172 |
| A | LYS212 |
| A | TYR216 |
| A | ASP255 |
| A | LYS269 |
| A | MG1368 |
| A | MG1369 |
| A | MG1370 |
| A | HOH2028 |
| B | ASN131 |
| B | LEU134 |
| site_id | AC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE PVZ B 1371 |
| Chain | Residue |
| A | ASN131 |
| A | HOH2037 |
| B | TYR99 |
| B | ASP103 |
| B | MET106 |
| B | ASP107 |
| B | ARG112 |
| B | ALA169 |
| B | GLN172 |
| B | LYS212 |
| B | THR213 |
| B | TYR216 |
| B | ASP255 |
| B | LYS269 |
| B | MG1368 |
| B | MG1369 |
| B | MG1370 |
| B | HOH2069 |
Functional Information from PROSITE/UniProt
