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5AFU

Cryo-EM structure of dynein tail-dynactin-BICD2N complex

Functional Information from GO Data
ChainGOidnamespacecontents
H0000786cellular_componentnucleosome
H0001738biological_processmorphogenesis of a polarized epithelium
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005634cellular_componentnucleus
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005856cellular_componentcytoskeleton
H0005884cellular_componentactin filament
H0005886cellular_componentplasma membrane
H0005903cellular_componentbrush border
H0005911cellular_componentcell-cell junction
H0005912cellular_componentadherens junction
H0005925cellular_componentfocal adhesion
H0007163biological_processestablishment or maintenance of cell polarity
H0007409biological_processaxonogenesis
H0015629cellular_componentactin cytoskeleton
H0016020cellular_componentmembrane
H0016787molecular_functionhydrolase activity
H0016887molecular_functionATP hydrolysis activity
H0019894molecular_functionkinesin binding
H0019901molecular_functionprotein kinase binding
H0030027cellular_componentlamellipodium
H0030424cellular_componentaxon
H0030863cellular_componentcortical cytoskeleton
H0030957molecular_functionTat protein binding
H0032991cellular_componentprotein-containing complex
H0034333biological_processadherens junction assembly
H0035267cellular_componentNuA4 histone acetyltransferase complex
H0036464cellular_componentcytoplasmic ribonucleoprotein granule
H0042802molecular_functionidentical protein binding
H0043296cellular_componentapical junction complex
H0044305cellular_componentcalyx of Held
H0045176biological_processapical protein localization
H0045202cellular_componentsynapse
H0048870biological_processcell motility
H0050998molecular_functionnitric-oxide synthase binding
H0051621biological_processregulation of norepinephrine uptake
H0051726biological_processregulation of cell cycle
H0070160cellular_componenttight junction
H0071896biological_processprotein localization to adherens junction
H0072749biological_processcellular response to cytochalasin B
H0097433cellular_componentdense body
H0098685cellular_componentSchaffer collateral - CA1 synapse
H0098871cellular_componentpostsynaptic actin cytoskeleton
H0098973molecular_functionstructural constituent of postsynaptic actin cytoskeleton
H0098974biological_processpostsynaptic actin cytoskeleton organization
H0098978cellular_componentglutamatergic synapse
H0150111biological_processregulation of transepithelial transport
H1900242biological_processregulation of synaptic vesicle endocytosis
H1903076biological_processregulation of protein localization to plasma membrane
H1905168biological_processpositive regulation of double-strand break repair via homologous recombination
H1990904cellular_componentribonucleoprotein complex
J0005737cellular_componentcytoplasm
J0005856cellular_componentcytoskeleton
J0005869cellular_componentdynactin complex
J0098958biological_processretrograde axonal transport of mitochondrion
J1904115cellular_componentaxon cytoplasm
K0003779molecular_functionactin binding
K0005737cellular_componentcytoplasm
K0005856cellular_componentcytoskeleton
K0008290cellular_componentF-actin capping protein complex
K0051016biological_processbarbed-end actin filament capping
K0051693biological_processactin filament capping
L0003779molecular_functionactin binding
L0005737cellular_componentcytoplasm
L0005856cellular_componentcytoskeleton
L0008290cellular_componentF-actin capping protein complex
L0030036biological_processactin cytoskeleton organization
L0051016biological_processbarbed-end actin filament capping
L0051693biological_processactin filament capping
U0005869cellular_componentdynactin complex
V0000775cellular_componentchromosome, centromeric region
V0000776cellular_componentkinetochore
V0003281biological_processventricular septum development
V0005654cellular_componentnucleoplasm
V0005694cellular_componentchromosome
V0005737cellular_componentcytoplasm
V0005813cellular_componentcentrosome
V0005856cellular_componentcytoskeleton
V0005869cellular_componentdynactin complex
V0031965cellular_componentnuclear membrane
V0035904biological_processaorta development
V0060976biological_processcoronary vasculature development
b0005737cellular_componentcytoplasm
b0005869cellular_componentdynactin complex
b0007017biological_processmicrotubule-based process
b0030286cellular_componentdynein complex
Functional Information from PROSITE/UniProt
site_idPS00231
Number of Residues6
DetailsF_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD
ChainResidueDetails
LCYS62-ASP67

site_idPS00406
Number of Residues11
DetailsACTINS_1 Actins signature 1. YVGDEAQs.KRG
ChainResidueDetails
HTYR53-GLY63

site_idPS00430
Number of Residues123
DetailsTONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pgavvcveseirgdvtigprtvihpkariiaeagpivigegnlieeqaliinaypdnitpdtekpmiigtnnvfevgcysqamkmgdnnvieskayvgrnviltsgciigaccnlNTFEVIPE
ChainResidueDetails
UPRO13-GLU135

site_idPS00432
Number of Residues9
DetailsACTINS_2 Actins signature 2. WVSKkEYEE
ChainResidueDetails
ATRP357-GLU365
HTRP356-GLU364

site_idPS00678
Number of Residues15
DetailsWD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGaeDrLIRIWDI
ChainResidueDetails
3LEU458-ILE472
3LEU500-LEU514
3ILE542-SER556
3VAL591-LEU605

site_idPS00748
Number of Residues9
DetailsF_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV
ChainResidueDetails
KVAL196-VAL204

site_idPS00749
Number of Residues11
DetailsF_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR
ChainResidueDetails
KLYS256-ARG266

site_idPS01132
Number of Residues13
DetailsACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR
ChainResidueDetails
ALEU109-ARG121
HLEU104-ARG116

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P52907
ChainResidueDetails
KSER9
HMET47

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P52907
ChainResidueDetails
KLYS19
KLYS97

site_idSWS_FT_FI3
Number of Residues1
DetailsMOD_RES: N6-methyllysine => ECO:0000250|UniProtKB:P60709
ChainResidueDetails
HLYS84

227561

PDB entries from 2024-11-20

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