Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AFU

Cryo-EM structure of dynein tail-dynactin-BICD2N complex

Functional Information from GO Data

Chain	GOid	namespace	contents
H	0000166	molecular_function	nucleotide binding
H	0000786	cellular_component	nucleosome
H	0001738	biological_process	morphogenesis of a polarized epithelium
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005856	cellular_component	cytoskeleton
H	0005884	cellular_component	actin filament
H	0005886	cellular_component	plasma membrane
H	0005903	cellular_component	brush border
H	0005911	cellular_component	cell-cell junction
H	0005912	cellular_component	adherens junction
H	0005925	cellular_component	focal adhesion
H	0007163	biological_process	establishment or maintenance of cell polarity
H	0007409	biological_process	axonogenesis
H	0015629	cellular_component	actin cytoskeleton
H	0016020	cellular_component	membrane
H	0016787	molecular_function	hydrolase activity
H	0016887	molecular_function	ATP hydrolysis activity
H	0019894	molecular_function	kinesin binding
H	0019901	molecular_function	protein kinase binding
H	0030027	cellular_component	lamellipodium
H	0030235	molecular_function	nitric-oxide synthase regulator activity
H	0030424	cellular_component	axon
H	0030863	cellular_component	cortical cytoskeleton
H	0030957	molecular_function	Tat protein binding
H	0032991	cellular_component	protein-containing complex
H	0034333	biological_process	adherens junction assembly
H	0035267	cellular_component	NuA4 histone acetyltransferase complex
H	0036464	cellular_component	cytoplasmic ribonucleoprotein granule
H	0042802	molecular_function	identical protein binding
H	0043296	cellular_component	apical junction complex
H	0044305	cellular_component	calyx of Held
H	0045176	biological_process	apical protein localization
H	0045202	cellular_component	synapse
H	0048870	biological_process	cell motility
H	0050998	molecular_function	nitric-oxide synthase binding
H	0051621	biological_process	regulation of norepinephrine uptake
H	0051726	biological_process	regulation of cell cycle
H	0070160	cellular_component	tight junction
H	0071896	biological_process	protein localization to adherens junction
H	0072749	biological_process	cellular response to cytochalasin B
H	0097433	cellular_component	dense body
H	0098685	cellular_component	Schaffer collateral - CA1 synapse
H	0098871	cellular_component	postsynaptic actin cytoskeleton
H	0098973	molecular_function	structural constituent of postsynaptic actin cytoskeleton
H	0098974	biological_process	postsynaptic actin cytoskeleton organization
H	0098978	cellular_component	glutamatergic synapse
H	0141108	molecular_function	transporter regulator activity
H	0150111	biological_process	regulation of transepithelial transport
H	1900242	biological_process	regulation of synaptic vesicle endocytosis
H	1903076	biological_process	regulation of protein localization to plasma membrane
H	1905168	biological_process	positive regulation of double-strand break repair via homologous recombination
H	1990904	cellular_component	ribonucleoprotein complex
J	0005856	cellular_component	cytoskeleton
J	0005869	cellular_component	dynactin complex
J	0098958	biological_process	retrograde axonal transport of mitochondrion
J	1904115	cellular_component	axon cytoplasm
K	0003779	molecular_function	actin binding
K	0005829	cellular_component	cytosol
K	0005856	cellular_component	cytoskeleton
K	0008290	cellular_component	F-actin capping protein complex
K	0030036	biological_process	actin cytoskeleton organization
K	0030863	cellular_component	cortical cytoskeleton
K	0051015	molecular_function	actin filament binding
K	0051016	biological_process	barbed-end actin filament capping
K	0051693	biological_process	actin filament capping
L	0003779	molecular_function	actin binding
L	0005737	cellular_component	cytoplasm
L	0005856	cellular_component	cytoskeleton
L	0008290	cellular_component	F-actin capping protein complex
L	0030036	biological_process	actin cytoskeleton organization
L	0051016	biological_process	barbed-end actin filament capping
L	0051693	biological_process	actin filament capping
U	0005869	cellular_component	dynactin complex
V	0000776	cellular_component	kinetochore
V	0003281	biological_process	ventricular septum development
V	0005654	cellular_component	nucleoplasm
V	0005813	cellular_component	centrosome
V	0005856	cellular_component	cytoskeleton
V	0005869	cellular_component	dynactin complex
V	0031965	cellular_component	nuclear membrane
V	0035904	biological_process	aorta development
V	0060976	biological_process	coronary vasculature development
b	0005737	cellular_component	cytoplasm
b	0005869	cellular_component	dynactin complex
b	0007017	biological_process	microtubule-based process
b	0030286	cellular_component	dynein complex

Functional Information from PROSITE/UniProt

site_id	PS00231
Number of Residues	6
Details	F_ACTIN_CAPPING_BETA F-actin capping protein beta subunit signature. CDYNRD

Chain	Residue	Details
L	CYS62-ASP67

site_id	PS00406
Number of Residues	11
Details	ACTINS_1 Actins signature 1. YVGDEAQs.KRG

Chain	Residue	Details
H	TYR53-GLY63

site_id	PS00430
Number of Residues	123
Details	TONB_DEPENDENT_REC_1 TonB-dependent receptor (TBDR) proteins signature 1. pgavvcveseirgdvtigprtvihpkariiaeagpivigegnlieeqaliinaypdnitpdtekpmiigtnnvfevgcysqamkmgdnnvieskayvgrnviltsgciigaccnlNTFEVIPE

Chain	Residue	Details
U	PRO13-GLU135

site_id	PS00432
Number of Residues	9
Details	ACTINS_2 Actins signature 2. WVSKkEYEE

Chain	Residue	Details
A	TRP357-GLU365
H	TRP356-GLU364

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LATGaeDrLIRIWDI

Chain	Residue	Details
3	LEU458-ILE472
3	LEU500-LEU514
3	ILE542-SER556
3	VAL591-LEU605

site_id	PS00748
Number of Residues	9
Details	F_ACTIN_CAPPING_A_1 F-actin capping protein alpha subunit signature 1. VHYYEDGNV

Chain	Residue	Details
K	VAL196-VAL204

site_id	PS00749
Number of Residues	11
Details	F_ACTIN_CAPPING_A_2 F-actin capping protein alpha subunit signature 2. KaLRRqLPVTR

Chain	Residue	Details
K	LYS256-ARG266

site_id	PS01132
Number of Residues	13
Details	ACTINS_ACT_LIKE Actins and actin-related proteins signature. LLTEApLNPrkNR

Chain	Residue	Details
A	LEU109-ARG121
H	LEU104-ARG116

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI2
Number of Residues	2
Details	Modified residue: {"description":"Methionine (R)-sulfoxide","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Tele-methylhistidine","evidences":[{"source":"UniProtKB","id":"P60710","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Modified residue: {"description":"N6-methyllysine","evidences":[{"source":"UniProtKB","id":"P60709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P52907","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)