5AEX
Crystal structure of Saccharomyces cerevisiae Mep2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007124 | biological_process | pseudohyphal growth |
| A | 0008519 | molecular_function | ammonium channel activity |
| A | 0016020 | cellular_component | membrane |
| A | 0019740 | biological_process | nitrogen utilization |
| A | 0072488 | biological_process | ammonium transmembrane transport |
| A | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0007124 | biological_process | pseudohyphal growth |
| B | 0008519 | molecular_function | ammonium channel activity |
| B | 0016020 | cellular_component | membrane |
| B | 0019740 | biological_process | nitrogen utilization |
| B | 0072488 | biological_process | ammonium transmembrane transport |
| B | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0007124 | biological_process | pseudohyphal growth |
| C | 0008519 | molecular_function | ammonium channel activity |
| C | 0016020 | cellular_component | membrane |
| C | 0019740 | biological_process | nitrogen utilization |
| C | 0072488 | biological_process | ammonium transmembrane transport |
| C | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0007124 | biological_process | pseudohyphal growth |
| D | 0008519 | molecular_function | ammonium channel activity |
| D | 0016020 | cellular_component | membrane |
| D | 0019740 | biological_process | nitrogen utilization |
| D | 0072488 | biological_process | ammonium transmembrane transport |
| D | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| E | 0005886 | cellular_component | plasma membrane |
| E | 0007124 | biological_process | pseudohyphal growth |
| E | 0008519 | molecular_function | ammonium channel activity |
| E | 0016020 | cellular_component | membrane |
| E | 0019740 | biological_process | nitrogen utilization |
| E | 0072488 | biological_process | ammonium transmembrane transport |
| E | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| F | 0005886 | cellular_component | plasma membrane |
| F | 0007124 | biological_process | pseudohyphal growth |
| F | 0008519 | molecular_function | ammonium channel activity |
| F | 0016020 | cellular_component | membrane |
| F | 0019740 | biological_process | nitrogen utilization |
| F | 0072488 | biological_process | ammonium transmembrane transport |
| F | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| H | 0005886 | cellular_component | plasma membrane |
| H | 0007124 | biological_process | pseudohyphal growth |
| H | 0008519 | molecular_function | ammonium channel activity |
| H | 0016020 | cellular_component | membrane |
| H | 0019740 | biological_process | nitrogen utilization |
| H | 0072488 | biological_process | ammonium transmembrane transport |
| H | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0007124 | biological_process | pseudohyphal growth |
| I | 0008519 | molecular_function | ammonium channel activity |
| I | 0016020 | cellular_component | membrane |
| I | 0019740 | biological_process | nitrogen utilization |
| I | 0072488 | biological_process | ammonium transmembrane transport |
| I | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
| J | 0005886 | cellular_component | plasma membrane |
| J | 0007124 | biological_process | pseudohyphal growth |
| J | 0008519 | molecular_function | ammonium channel activity |
| J | 0016020 | cellular_component | membrane |
| J | 0019740 | biological_process | nitrogen utilization |
| J | 0072488 | biological_process | ammonium transmembrane transport |
| J | 1900430 | biological_process | positive regulation of filamentous growth of a population of unicellular organisms |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 A 1458 |
| Chain | Residue |
| A | GLY440 |
| A | GLU441 |
| A | PHE442 |
| A | THR443 |
| A | TYR444 |
| A | GLU445 |
| B | THR229 |
| B | GLU441 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 C 1458 |
| Chain | Residue |
| A | GLU441 |
| C | GLY440 |
| C | GLU441 |
| C | PHE442 |
| C | THR443 |
| C | TYR444 |
| A | THR229 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE PO4 B 1458 |
| Chain | Residue |
| B | GLY440 |
| B | GLU441 |
| B | PHE442 |
| B | THR443 |
| B | TYR444 |
| B | GLU445 |
| C | THR229 |
| C | GLU441 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 D 1458 |
| Chain | Residue |
| D | GLY440 |
| D | GLU441 |
| D | PHE442 |
| D | THR443 |
| D | TYR444 |
| E | THR229 |
| E | GLU441 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 F 1458 |
| Chain | Residue |
| D | THR229 |
| D | GLU441 |
| F | GLU441 |
| F | PHE442 |
| F | THR443 |
| F | TYR444 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 E 1458 |
| Chain | Residue |
| E | GLY440 |
| E | GLU441 |
| E | PHE442 |
| E | THR443 |
| E | TYR444 |
| F | THR229 |
| F | GLU441 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 H 1457 |
| Chain | Residue |
| H | GLY440 |
| H | GLU441 |
| H | PHE442 |
| H | THR443 |
| H | TYR444 |
| I | THR229 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 J 1455 |
| Chain | Residue |
| H | THR229 |
| H | GLU441 |
| J | GLY440 |
| J | GLU441 |
| J | PHE442 |
| J | THR443 |
| J | TYR444 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 I 1455 |
| Chain | Residue |
| I | GLU441 |
| I | PHE442 |
| I | THR443 |
| I | TYR444 |
| I | GLU445 |
| J | THR229 |
| J | GLU441 |
Functional Information from PROSITE/UniProt
| site_id | PS01219 |
| Number of Residues | 26 |
| Details | AMMONIUM_TRANSP Ammonium transporters signature. DYAGGlcVhltSGhgGLvyaLIlGkR |
| Chain | Residue | Details |
| A | ASP186-ARG211 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 270 |
| Details | TOPO_DOM: Extracellular => ECO:0000269|PubMed:11069679 |
| Chain | Residue | Details |
| A | MET1-ASN31 | |
| B | MET1-ASN31 | |
| C | MET1-ASN31 | |
| D | MET1-ASN31 | |
| E | MET1-ASN31 | |
| F | MET1-ASN31 | |
| H | MET1-ASN31 | |
| I | MET1-ASN31 | |
| J | MET1-ASN31 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET32-LEU52 | |
| B | MET32-LEU52 | |
| C | MET32-LEU52 | |
| D | MET32-LEU52 | |
| E | MET32-LEU52 | |
| F | MET32-LEU52 | |
| H | MET32-LEU52 | |
| I | MET32-LEU52 | |
| J | MET32-LEU52 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1251 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | TYR53-ALA62 | |
| B | ASP279-THR289 | |
| B | ASP339-SER346 | |
| B | MET415-VAL499 | |
| C | TYR53-ALA62 | |
| C | ALA144-PRO152 | |
| C | GLY209-SER230 | |
| C | ASP279-THR289 | |
| C | ASP339-SER346 | |
| C | MET415-VAL499 | |
| D | TYR53-ALA62 | |
| A | ALA144-PRO152 | |
| D | ALA144-PRO152 | |
| D | GLY209-SER230 | |
| D | ASP279-THR289 | |
| D | ASP339-SER346 | |
| D | MET415-VAL499 | |
| E | TYR53-ALA62 | |
| E | ALA144-PRO152 | |
| E | GLY209-SER230 | |
| E | ASP279-THR289 | |
| E | ASP339-SER346 | |
| A | GLY209-SER230 | |
| E | MET415-VAL499 | |
| F | TYR53-ALA62 | |
| F | ALA144-PRO152 | |
| F | GLY209-SER230 | |
| F | ASP279-THR289 | |
| F | ASP339-SER346 | |
| F | MET415-VAL499 | |
| H | TYR53-ALA62 | |
| H | ALA144-PRO152 | |
| H | GLY209-SER230 | |
| A | ASP279-THR289 | |
| H | ASP279-THR289 | |
| H | ASP339-SER346 | |
| H | MET415-VAL499 | |
| I | TYR53-ALA62 | |
| I | ALA144-PRO152 | |
| I | GLY209-SER230 | |
| I | ASP279-THR289 | |
| I | ASP339-SER346 | |
| I | MET415-VAL499 | |
| J | TYR53-ALA62 | |
| A | ASP339-SER346 | |
| J | ALA144-PRO152 | |
| J | GLY209-SER230 | |
| J | ASP279-THR289 | |
| J | ASP339-SER346 | |
| J | MET415-VAL499 | |
| A | MET415-VAL499 | |
| B | TYR53-ALA62 | |
| B | ALA144-PRO152 | |
| B | GLY209-SER230 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU63-TRP83 | |
| B | LEU63-TRP83 | |
| C | LEU63-TRP83 | |
| D | LEU63-TRP83 | |
| E | LEU63-TRP83 | |
| F | LEU63-TRP83 | |
| H | LEU63-TRP83 | |
| I | LEU63-TRP83 | |
| J | LEU63-TRP83 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 747 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | GLY84-ASP122 | |
| B | ASN368-GLN393 | |
| C | GLY84-ASP122 | |
| C | ASN174-TYR187 | |
| C | ASN252-ALA257 | |
| C | TRP313-ALA315 | |
| C | ASN368-GLN393 | |
| D | GLY84-ASP122 | |
| D | ASN174-TYR187 | |
| D | ASN252-ALA257 | |
| D | TRP313-ALA315 | |
| A | ASN174-TYR187 | |
| D | ASN368-GLN393 | |
| E | GLY84-ASP122 | |
| E | ASN174-TYR187 | |
| E | ASN252-ALA257 | |
| E | TRP313-ALA315 | |
| E | ASN368-GLN393 | |
| F | GLY84-ASP122 | |
| F | ASN174-TYR187 | |
| F | ASN252-ALA257 | |
| F | TRP313-ALA315 | |
| A | ASN252-ALA257 | |
| F | ASN368-GLN393 | |
| H | GLY84-ASP122 | |
| H | ASN174-TYR187 | |
| H | ASN252-ALA257 | |
| H | TRP313-ALA315 | |
| H | ASN368-GLN393 | |
| I | GLY84-ASP122 | |
| I | ASN174-TYR187 | |
| I | ASN252-ALA257 | |
| I | TRP313-ALA315 | |
| A | TRP313-ALA315 | |
| I | ASN368-GLN393 | |
| J | GLY84-ASP122 | |
| J | ASN174-TYR187 | |
| J | ASN252-ALA257 | |
| J | TRP313-ALA315 | |
| J | ASN368-GLN393 | |
| A | ASN368-GLN393 | |
| B | GLY84-ASP122 | |
| B | ASN174-TYR187 | |
| B | ASN252-ALA257 | |
| B | TRP313-ALA315 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE123-GLY143 | |
| B | ILE123-GLY143 | |
| C | ILE123-GLY143 | |
| D | ILE123-GLY143 | |
| E | ILE123-GLY143 | |
| F | ILE123-GLY143 | |
| H | ILE123-GLY143 | |
| I | ILE123-GLY143 | |
| J | ILE123-GLY143 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000255 |
| Chain | Residue | Details |
| A | MET153-TRP173 | |
| B | MET153-TRP173 | |
| C | MET153-TRP173 | |
| D | MET153-TRP173 | |
| E | MET153-TRP173 | |
| F | MET153-TRP173 | |
| H | MET153-TRP173 | |
| I | MET153-TRP173 | |
| J | MET153-TRP173 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA188-LEU208 | |
| B | ALA188-LEU208 | |
| C | ALA188-LEU208 | |
| D | ALA188-LEU208 | |
| E | ALA188-LEU208 | |
| F | ALA188-LEU208 | |
| H | ALA188-LEU208 | |
| I | ALA188-LEU208 | |
| J | ALA188-LEU208 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL231-GLY251 | |
| B | VAL231-GLY251 | |
| C | VAL231-GLY251 | |
| D | VAL231-GLY251 | |
| E | VAL231-GLY251 | |
| F | VAL231-GLY251 | |
| H | VAL231-GLY251 | |
| I | VAL231-GLY251 | |
| J | VAL231-GLY251 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000255 |
| Chain | Residue | Details |
| A | TRP258-ILE278 | |
| B | TRP258-ILE278 | |
| C | TRP258-ILE278 | |
| D | TRP258-ILE278 | |
| E | TRP258-ILE278 | |
| F | TRP258-ILE278 | |
| H | TRP258-ILE278 | |
| I | TRP258-ILE278 | |
| J | TRP258-ILE278 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 198 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL290-ILE312 | |
| B | VAL290-ILE312 | |
| C | VAL290-ILE312 | |
| D | VAL290-ILE312 | |
| E | VAL290-ILE312 | |
| F | VAL290-ILE312 | |
| H | VAL290-ILE312 | |
| I | VAL290-ILE312 | |
| J | VAL290-ILE312 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 198 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000255 |
| Chain | Residue | Details |
| A | VAL316-ILE338 | |
| B | VAL316-ILE338 | |
| C | VAL316-ILE338 | |
| D | VAL316-ILE338 | |
| E | VAL316-ILE338 | |
| F | VAL316-ILE338 | |
| H | VAL316-ILE338 | |
| I | VAL316-ILE338 | |
| J | VAL316-ILE338 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000255 |
| Chain | Residue | Details |
| A | ILE347-VAL367 | |
| B | ILE347-VAL367 | |
| C | ILE347-VAL367 | |
| D | ILE347-VAL367 | |
| E | ILE347-VAL367 | |
| F | ILE347-VAL367 | |
| H | ILE347-VAL367 | |
| I | ILE347-VAL367 | |
| J | ILE347-VAL367 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 180 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU394-THR414 | |
| B | LEU394-THR414 | |
| C | LEU394-THR414 | |
| D | LEU394-THR414 | |
| E | LEU394-THR414 | |
| F | LEU394-THR414 | |
| H | LEU394-THR414 | |
| I | LEU394-THR414 | |
| J | LEU394-THR414 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 9 |
| Details | MOD_RES: Phosphoserine => ECO:0000269|PubMed:24476960, ECO:0000269|PubMed:27088325, ECO:0007744|PDB:5AEX |
| Chain | Residue | Details |
| A | SER457 | |
| B | SER457 | |
| C | SER457 | |
| D | SER457 | |
| E | SER457 | |
| F | SER457 | |
| H | SER457 | |
| I | SER457 | |
| J | SER457 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 9 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11069679 |
| Chain | Residue | Details |
| A | ASN4 | |
| B | ASN4 | |
| C | ASN4 | |
| D | ASN4 | |
| E | ASN4 | |
| F | ASN4 | |
| H | ASN4 | |
| I | ASN4 | |
| J | ASN4 |
