5AEX

Crystal structure of Saccharomyces cerevisiae Mep2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0007124	biological_process	pseudohyphal growth
A	0008519	molecular_function	ammonium channel activity
A	0016020	cellular_component	membrane
A	0019740	biological_process	nitrogen utilization
A	0072488	biological_process	ammonium transmembrane transport
A	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
B	0005886	cellular_component	plasma membrane
B	0007124	biological_process	pseudohyphal growth
B	0008519	molecular_function	ammonium channel activity
B	0016020	cellular_component	membrane
B	0019740	biological_process	nitrogen utilization
B	0072488	biological_process	ammonium transmembrane transport
B	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
C	0005886	cellular_component	plasma membrane
C	0007124	biological_process	pseudohyphal growth
C	0008519	molecular_function	ammonium channel activity
C	0016020	cellular_component	membrane
C	0019740	biological_process	nitrogen utilization
C	0072488	biological_process	ammonium transmembrane transport
C	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
D	0005886	cellular_component	plasma membrane
D	0007124	biological_process	pseudohyphal growth
D	0008519	molecular_function	ammonium channel activity
D	0016020	cellular_component	membrane
D	0019740	biological_process	nitrogen utilization
D	0072488	biological_process	ammonium transmembrane transport
D	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
E	0005886	cellular_component	plasma membrane
E	0007124	biological_process	pseudohyphal growth
E	0008519	molecular_function	ammonium channel activity
E	0016020	cellular_component	membrane
E	0019740	biological_process	nitrogen utilization
E	0072488	biological_process	ammonium transmembrane transport
E	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
F	0005886	cellular_component	plasma membrane
F	0007124	biological_process	pseudohyphal growth
F	0008519	molecular_function	ammonium channel activity
F	0016020	cellular_component	membrane
F	0019740	biological_process	nitrogen utilization
F	0072488	biological_process	ammonium transmembrane transport
F	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
H	0005886	cellular_component	plasma membrane
H	0007124	biological_process	pseudohyphal growth
H	0008519	molecular_function	ammonium channel activity
H	0016020	cellular_component	membrane
H	0019740	biological_process	nitrogen utilization
H	0072488	biological_process	ammonium transmembrane transport
H	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
I	0005886	cellular_component	plasma membrane
I	0007124	biological_process	pseudohyphal growth
I	0008519	molecular_function	ammonium channel activity
I	0016020	cellular_component	membrane
I	0019740	biological_process	nitrogen utilization
I	0072488	biological_process	ammonium transmembrane transport
I	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms
J	0005886	cellular_component	plasma membrane
J	0007124	biological_process	pseudohyphal growth
J	0008519	molecular_function	ammonium channel activity
J	0016020	cellular_component	membrane
J	0019740	biological_process	nitrogen utilization
J	0072488	biological_process	ammonium transmembrane transport
J	1900430	biological_process	positive regulation of filamentous growth of a population of unicellular organisms

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 A 1458

Chain	Residue
A	GLY440
A	GLU441
A	PHE442
A	THR443
A	TYR444
A	GLU445
B	THR229
B	GLU441

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 C 1458

Chain	Residue
A	GLU441
C	GLY440
C	GLU441
C	PHE442
C	THR443
C	TYR444
A	THR229

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 B 1458

Chain	Residue
B	GLY440
B	GLU441
B	PHE442
B	THR443
B	TYR444
B	GLU445
C	THR229
C	GLU441

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 D 1458

Chain	Residue
D	GLY440
D	GLU441
D	PHE442
D	THR443
D	TYR444
E	THR229
E	GLU441

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 F 1458

Chain	Residue
D	THR229
D	GLU441
F	GLU441
F	PHE442
F	THR443
F	TYR444

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 E 1458

Chain	Residue
E	GLY440
E	GLU441
E	PHE442
E	THR443
E	TYR444
F	THR229
F	GLU441

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE PO4 H 1457

Chain	Residue
H	GLY440
H	GLU441
H	PHE442
H	THR443
H	TYR444
I	THR229

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 J 1455

Chain	Residue
H	THR229
H	GLU441
J	GLY440
J	GLU441
J	PHE442
J	THR443
J	TYR444

---

site_id	AC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PO4 I 1455

Chain	Residue
I	GLU441
I	PHE442
I	THR443
I	TYR444
I	GLU445
J	THR229
J	GLU441

---

Functional Information from PROSITE/UniProt

site_id	PS01219
Number of Residues	26
Details	AMMONIUM_TRANSP Ammonium transporters signature. DYAGGlcVhltSGhgGLvyaLIlGkR

Chain	Residue	Details
A	ASP186-ARG211

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	453
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	747
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	198
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	198
Details	Transmembrane: {"description":"Helical; Name=9","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=10","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	180
Details	Transmembrane: {"description":"Helical; Name=11","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	78
Details	Region: {"description":"Enhancer domain","evidences":[{"source":"PubMed","id":"32069286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	63
Details	Region: {"description":"Linker domain","evidences":[{"source":"PubMed","id":"32069286","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24476960","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27088325","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AEX","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	9
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"11069679","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---