5AEU

Crystal structure of II9 variant of Biphenyl dioxygenase from Burkholderia xenovorans LB400

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005506	molecular_function	iron ion binding
A	0016491	molecular_function	oxidoreductase activity
A	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
A	0019439	biological_process	obsolete aromatic compound catabolic process
A	0044237	biological_process	cellular metabolic process
A	0046872	molecular_function	metal ion binding
A	0051213	molecular_function	dioxygenase activity
A	0051536	molecular_function	iron-sulfur cluster binding
A	0051537	molecular_function	2 iron, 2 sulfur cluster binding
B	0006725	biological_process	obsolete cellular aromatic compound metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
B	0019380	biological_process	3-phenylpropionate catabolic process
B	0019439	biological_process	obsolete aromatic compound catabolic process
B	0051213	molecular_function	dioxygenase activity
C	0005506	molecular_function	iron ion binding
C	0016491	molecular_function	oxidoreductase activity
C	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
C	0019439	biological_process	obsolete aromatic compound catabolic process
C	0044237	biological_process	cellular metabolic process
C	0046872	molecular_function	metal ion binding
C	0051213	molecular_function	dioxygenase activity
C	0051536	molecular_function	iron-sulfur cluster binding
C	0051537	molecular_function	2 iron, 2 sulfur cluster binding
D	0006725	biological_process	obsolete cellular aromatic compound metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
D	0019380	biological_process	3-phenylpropionate catabolic process
D	0019439	biological_process	obsolete aromatic compound catabolic process
D	0051213	molecular_function	dioxygenase activity
E	0005506	molecular_function	iron ion binding
E	0016491	molecular_function	oxidoreductase activity
E	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
E	0019439	biological_process	obsolete aromatic compound catabolic process
E	0044237	biological_process	cellular metabolic process
E	0046872	molecular_function	metal ion binding
E	0051213	molecular_function	dioxygenase activity
E	0051536	molecular_function	iron-sulfur cluster binding
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0006725	biological_process	obsolete cellular aromatic compound metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
F	0019380	biological_process	3-phenylpropionate catabolic process
F	0019439	biological_process	obsolete aromatic compound catabolic process
F	0051213	molecular_function	dioxygenase activity
G	0005506	molecular_function	iron ion binding
G	0016491	molecular_function	oxidoreductase activity
G	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
G	0019439	biological_process	obsolete aromatic compound catabolic process
G	0044237	biological_process	cellular metabolic process
G	0046872	molecular_function	metal ion binding
G	0051213	molecular_function	dioxygenase activity
G	0051536	molecular_function	iron-sulfur cluster binding
G	0051537	molecular_function	2 iron, 2 sulfur cluster binding
H	0006725	biological_process	obsolete cellular aromatic compound metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0018687	molecular_function	biphenyl 2,3-dioxygenase activity
H	0019380	biological_process	3-phenylpropionate catabolic process
H	0019439	biological_process	obsolete aromatic compound catabolic process
H	0051213	molecular_function	dioxygenase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES A 500

Chain	Residue
A	CYS100
A	HIS102
A	ARG103
A	CYS120
A	HIS123
A	TRP125

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 A 501

Chain	Residue
A	ASP388
A	HOH2059
A	HOH2063
A	HOH2066
A	GLN226
A	HIS233
A	HIS239

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES C 500

Chain	Residue
C	CYS100
C	HIS102
C	ARG103
C	CYS120
C	HIS123
C	GLY124
C	TRP125

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 C 501

Chain	Residue
C	GLN226
C	HIS233
C	HIS239
C	ASP388
C	HOH2020
C	HOH2022
C	HOH2025

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FES E 500

Chain	Residue
E	CYS100
E	HIS102
E	ARG103
E	CYS120
E	TYR122
E	HIS123
E	TRP125

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE FE2 E 501

Chain	Residue
E	GLN226
E	HIS233
E	HIS239
E	ASP388
E	HOH2012
E	HOH2013
E	HOH2017

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FES G 500

Chain	Residue
G	CYS100
G	HIS102
G	ARG103
G	CYS120
G	HIS123
G	TRP125

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE FE2 G 501

Chain	Residue
G	GLN226
G	HIS233
G	HIS239
G	ASP388
G	HOH2005
G	HOH2013

---

Functional Information from PROSITE/UniProt

site_id	PS00570
Number of Residues	24
Details	RING_HYDROXYL_ALPHA Bacterial ring hydroxylating dioxygenases alpha-subunit signature. CrHRGmricrsdaGNakaftCsYH

Chain	Residue	Details
A	CYS100-HIS123

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00628

Chain	Residue	Details
A	CYS100
E	HIS102
E	CYS120
E	HIS123
G	CYS100
G	HIS102
G	CYS120
G	HIS123
A	HIS102
A	CYS120
A	HIS123
C	CYS100
C	HIS102
C	CYS120
C	HIS123
E	CYS100

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	HIS233
A	HIS239
C	HIS233
C	HIS239
E	HIS233
E	HIS239
G	HIS233
G	HIS239

---