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5ADQ

Crystal structure of human tankyrase 2 in complex with JW55

Functional Information from GO Data
ChainGOidnamespacecontents
A0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
B0003950molecular_functionNAD+-protein poly-ADP-ribosyltransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 2114
ChainResidue
ACYS1081
AHIS1084
ACYS1089
ACYS1092

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 2115
ChainResidue
AARG977
AHIS979
AARG980
ALYS1067
AGLN1070

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 2116
ChainResidue
AASN990
AARG991
AHOH2034
BPRO1160
BGLU1161

site_idAC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE A95 A 2117
ChainResidue
AHIS1031
APRO1034
APHE1035
AILE1039
AGLY1043
APHE1044
AASP1045
AHIS1048
AILE1051
AGLY1053
ATYR1060
ATYR1071
AGLY1074

site_idAC5
Number of Residues5
DetailsBINDING SITE FOR RESIDUE BCT A 2118
ChainResidue
APHE1030
AHIS1031
AGLY1032
ATYR1060
ASER1068

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 2119
ChainResidue
ASER974
ATHR975
AVAL976
AASN1064
APHE1110
BLEU1134
BLEU1136

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:O95271
ChainResidueDetails
ACYS1081
AHIS1084
ACYS1089
ACYS1092

227561

PDB entries from 2024-11-20

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