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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5AC1

Sheep aldehyde dehydrogenase 1A1 with duocarmycin analog inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001523biological_processretinoid metabolic process
A0001758molecular_functionretinal dehydrogenase (NAD+) activity
A0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
A0004030molecular_functionaldehyde dehydrogenase [NAD(P)+] activity
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0009449biological_processgamma-aminobutyric acid biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
A0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
A0030392biological_processfructosamine catabolic process
A0030424cellular_componentaxon
A0036438biological_processmaintenance of lens transparency
A0042572biological_processretinol metabolic process
A0045202cellular_componentsynapse
A0051287molecular_functionNAD binding
A0106373molecular_function3-deoxyglucosone dehydrogenase activity
A0110095biological_processcellular detoxification of aldehyde
A0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
B0001523biological_processretinoid metabolic process
B0001758molecular_functionretinal dehydrogenase (NAD+) activity
B0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
B0004030molecular_functionaldehyde dehydrogenase [NAD(P)+] activity
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0009449biological_processgamma-aminobutyric acid biosynthetic process
B0016491molecular_functionoxidoreductase activity
B0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
B0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
B0030392biological_processfructosamine catabolic process
B0030424cellular_componentaxon
B0036438biological_processmaintenance of lens transparency
B0042572biological_processretinol metabolic process
B0045202cellular_componentsynapse
B0051287molecular_functionNAD binding
B0106373molecular_function3-deoxyglucosone dehydrogenase activity
B0110095biological_processcellular detoxification of aldehyde
B0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
C0001523biological_processretinoid metabolic process
C0001758molecular_functionretinal dehydrogenase (NAD+) activity
C0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
C0004030molecular_functionaldehyde dehydrogenase [NAD(P)+] activity
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0009449biological_processgamma-aminobutyric acid biosynthetic process
C0016491molecular_functionoxidoreductase activity
C0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
C0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
C0030392biological_processfructosamine catabolic process
C0030424cellular_componentaxon
C0036438biological_processmaintenance of lens transparency
C0042572biological_processretinol metabolic process
C0045202cellular_componentsynapse
C0051287molecular_functionNAD binding
C0106373molecular_function3-deoxyglucosone dehydrogenase activity
C0110095biological_processcellular detoxification of aldehyde
C0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
D0001523biological_processretinoid metabolic process
D0001758molecular_functionretinal dehydrogenase (NAD+) activity
D0004029molecular_functionaldehyde dehydrogenase (NAD+) activity
D0004030molecular_functionaldehyde dehydrogenase [NAD(P)+] activity
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0009449biological_processgamma-aminobutyric acid biosynthetic process
D0016491molecular_functionoxidoreductase activity
D0016620molecular_functionoxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D0018479molecular_functionbenzaldehyde dehydrogenase (NAD+) activity
D0019145molecular_functionaminobutyraldehyde dehydrogenase (NAD+) activity
D0030392biological_processfructosamine catabolic process
D0030424cellular_componentaxon
D0036438biological_processmaintenance of lens transparency
D0042572biological_processretinol metabolic process
D0045202cellular_componentsynapse
D0051287molecular_functionNAD binding
D0106373molecular_function3-deoxyglucosone dehydrogenase activity
D0110095biological_processcellular detoxification of aldehyde
D0140087molecular_functionacetaldehyde dehydrogenase (NAD+) activity
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE K9P A 501
ChainResidue
AMET120
ASER457
APHE170
ALEU173
AMET174
AGLN292
AGLY293
ATYR296
ACYS301
ACYS302
site_idAC2
Number of Residues29
DetailsBINDING SITE FOR RESIDUE TXE A 550
ChainResidue
AILE165
AILE166
APRO167
ATRP168
AASN169
ALYS192
AALA194
AGLU195
AGLY225
AGLY229
AALA230
APHE243
AGLY245
ASER246
AVAL249
AGLU268
ALEU269
AGLY270
ACYS302
AGLN349
ALYS352
AGLU399
AMG551
AHOH2104
AHOH2114
AHOH2124
AHOH2169
AHOH2211
AHOH2213
site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG A 551
ChainResidue
ATXE550
AHOH2134
AHOH2169
AHOH2211
AHOH2212
site_idAC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K9P B 501
ChainResidue
BMET120
BPHE170
BMET174
BGLN292
BTYR296
BCYS301
BCYS302
site_idAC5
Number of Residues29
DetailsBINDING SITE FOR RESIDUE TXE B 550
ChainResidue
BILE165
BILE166
BPRO167
BTRP168
BASN169
BLYS192
BALA194
BGLU195
BGLY225
BGLY229
BALA230
BPHE243
BGLY245
BSER246
BVAL249
BGLU268
BGLY270
BCYS302
BGLN349
BLYS352
BGLU399
BMG551
BHOH2103
BHOH2109
BHOH2123
BHOH2131
BHOH2188
BHOH2189
BHOH2190
site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 551
ChainResidue
BTXE550
BHOH2131
BHOH2188
site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K9P C 501
ChainResidue
CMET120
CPHE170
CLEU173
CGLN292
CTYR296
CCYS301
CCYS302
site_idAC8
Number of Residues30
DetailsBINDING SITE FOR RESIDUE TXE C 550
ChainResidue
CGLY225
CGLY229
CALA230
CPHE243
CGLY245
CSER246
CVAL249
CILE253
CGLU268
CGLY270
CCYS302
CGLU348
CGLN349
CLYS352
CGLU399
CPHE401
CMG551
CHOH2081
CHOH2096
CHOH2171
CHOH2172
AHOH2173
CILE165
CILE166
CPRO167
CTRP168
CASN169
CLYS192
CALA194
CGLU195
site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 551
ChainResidue
AHOH2173
CTXE550
CHOH2171
site_idBC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE K9P D 501
ChainResidue
DMET120
DPHE170
DLEU173
DGLN292
DGLY293
DTYR296
DCYS301
DCYS302
DSER457
site_idBC2
Number of Residues30
DetailsBINDING SITE FOR RESIDUE TXE D 550
ChainResidue
DILE165
DILE166
DPRO167
DTRP168
DASN169
DLYS192
DALA194
DGLU195
DGLY225
DGLY229
DALA230
DPHE243
DGLY245
DSER246
DVAL249
DGLU268
DLEU269
DGLY270
DCYS302
DGLN349
DLYS352
DGLU399
DMG551
DHOH2075
DHOH2081
DHOH2084
DHOH2089
DHOH2103
DHOH2126
DHOH2153
site_idBC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE MG D 551
ChainResidue
DTXE550
DHOH2097
DHOH2099
DHOH2126
DHOH2153
Functional Information from PROSITE/UniProt
site_idPS00070
Number of Residues12
DetailsALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FyHQGQCCIAAS
ChainResidueDetails
APHE295-SER306
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LELGGKSP
ChainResidueDetails
ALEU267-PRO274
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues660
DetailsRegion: {"description":"Mediates interaction with PRMT3","evidences":[{"source":"UniProtKB","id":"P00352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues4
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10007","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10008","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9862807","evidenceCode":"ECO:0000303"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues56
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26373694","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9862807","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BXS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5AC0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"26373694","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5AC0","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues4
DetailsSite: {"description":"Transition state stabilizer","evidences":[{"source":"UniProtKB","id":"P20000","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues32
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P00352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues4
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P00352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P00352","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

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PDB entries from 2025-12-10

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