5A8W
METHYL-COENZYME M REDUCTASE II FROM METHANOTHERMOBACTER WOLFEII AT 1. 8 A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015948 | biological_process | methanogenesis |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016740 | molecular_function | transferase activity |
| C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| D | 0015948 | biological_process | methanogenesis |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016740 | molecular_function | transferase activity |
| E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016740 | molecular_function | transferase activity |
| F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| G | 0015948 | biological_process | methanogenesis |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| H | 0015948 | biological_process | methanogenesis |
| H | 0016740 | molecular_function | transferase activity |
| H | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| I | 0015948 | biological_process | methanogenesis |
| I | 0016740 | molecular_function | transferase activity |
| I | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| J | 0015948 | biological_process | methanogenesis |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| K | 0015948 | biological_process | methanogenesis |
| K | 0016740 | molecular_function | transferase activity |
| K | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| L | 0015948 | biological_process | methanogenesis |
| L | 0016740 | molecular_function | transferase activity |
| L | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE COM A 1553 |
| Chain | Residue |
| A | TYR336 |
| A | PHE446 |
| A | TYR447 |
| A | HOH2379 |
| B | PHE361 |
| B | TYR367 |
| C | LEU120 |
| C | ARG123 |
| D | F431556 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 D 1553 |
| Chain | Residue |
| A | ARG229 |
| A | LYS260 |
| A | MHS261 |
| A | HOH2217 |
| D | ARG274 |
| D | LEU323 |
| D | MET327 |
| D | SER328 |
| D | PHE446 |
| D | MET483 |
| D | ASN484 |
| D | VAL485 |
| D | HOH2159 |
| D | HOH2164 |
| D | HOH2166 |
| D | HOH2263 |
| D | HOH2280 |
| E | TYR367 |
| E | GLY369 |
| E | HIS379 |
| E | VAL380 |
| site_id | AC3 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 D 1554 |
| Chain | Residue |
| A | ALA148 |
| A | VAL149 |
| A | VAL150 |
| A | GLN151 |
| A | GLN234 |
| A | MET237 |
| A | ALA247 |
| A | HOH2135 |
| A | HOH2138 |
| A | HOH2139 |
| A | HOH2140 |
| D | GLY329 |
| D | GLY330 |
| D | VAL331 |
| D | GLY332 |
| D | PHE333 |
| D | THR334 |
| D | GLN335 |
| D | TYR336 |
| D | PHE399 |
| D | GLY400 |
| D | GLY445 |
| D | PHE446 |
| D | COM1555 |
| D | HOH2224 |
| D | HOH2282 |
| D | HOH2283 |
| E | SER365 |
| E | ILE366 |
| E | TYR367 |
| F | LEU120 |
| F | SER121 |
| F | GLY122 |
| F | ALA156 |
| F | THR157 |
| F | VAL158 |
| F | HIS159 |
| F | HIS161 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE COM D 1555 |
| Chain | Residue |
| D | TYR336 |
| D | PHE446 |
| D | TYR447 |
| D | F431554 |
| D | HOH2284 |
| E | PHE361 |
| E | TYR367 |
| F | LEU120 |
| F | ARG123 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TP7 A 1554 |
| Chain | Residue |
| A | ARG274 |
| A | LEU323 |
| A | MET327 |
| A | SER328 |
| A | PHE333 |
| A | PHE446 |
| A | MET483 |
| A | ASN484 |
| A | VAL485 |
| A | HOH2233 |
| A | HOH2238 |
| A | HOH2240 |
| A | HOH2347 |
| A | HOH2378 |
| A | HOH2380 |
| B | TYR367 |
| B | GLY369 |
| B | HIS379 |
| B | VAL380 |
| D | ARG229 |
| D | LYS260 |
| D | MHS261 |
| site_id | AC6 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 D 1556 |
| Chain | Residue |
| A | GLY329 |
| A | GLY330 |
| A | VAL331 |
| A | GLY332 |
| A | PHE333 |
| A | THR334 |
| A | GLN335 |
| A | TYR336 |
| A | PHE399 |
| A | GLY400 |
| A | GLY445 |
| A | PHE446 |
| A | COM1553 |
| A | HOH2263 |
| A | HOH2303 |
| B | SER365 |
| B | ILE366 |
| B | TYR367 |
| C | LEU120 |
| C | SER121 |
| C | GLY122 |
| C | ALA156 |
| C | THR157 |
| C | VAL158 |
| C | HIS159 |
| C | HIS161 |
| C | HOH2091 |
| C | HOH2104 |
| C | HOH2105 |
| C | HOH2106 |
| D | ALA148 |
| D | VAL149 |
| D | VAL150 |
| D | GLN151 |
| D | GLN234 |
| D | MET237 |
| D | ALA247 |
| D | HOH2097 |
| site_id | AC7 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE COM G 1553 |
| Chain | Residue |
| G | TYR336 |
| G | PHE446 |
| G | TYR447 |
| G | F431554 |
| G | HOH2380 |
| H | PHE361 |
| H | SER365 |
| H | TYR367 |
| I | LEU120 |
| I | ARG123 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 J 1553 |
| Chain | Residue |
| G | ARG229 |
| G | LYS260 |
| G | MHS261 |
| G | HOH2219 |
| J | ARG274 |
| J | MET327 |
| J | PHE333 |
| J | PHE446 |
| J | MET483 |
| J | ASN484 |
| J | VAL485 |
| J | HOH2162 |
| J | HOH2167 |
| J | HOH2169 |
| J | HOH2268 |
| J | HOH2287 |
| K | TYR367 |
| K | GLY368 |
| K | GLY369 |
| K | HIS379 |
| K | VAL380 |
| site_id | AC9 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 J 1554 |
| Chain | Residue |
| G | ALA148 |
| G | VAL149 |
| G | VAL150 |
| G | GLN151 |
| G | GLN234 |
| G | MET237 |
| G | ALA247 |
| G | HOH2139 |
| G | HOH2142 |
| G | HOH2143 |
| G | HOH2144 |
| J | GLY329 |
| J | GLY330 |
| J | VAL331 |
| J | GLY332 |
| J | PHE333 |
| J | THR334 |
| J | GLN335 |
| J | TYR336 |
| J | PHE399 |
| J | GLY400 |
| J | GLY445 |
| J | PHE446 |
| J | COM1555 |
| J | HOH2229 |
| J | HOH2288 |
| J | HOH2290 |
| K | SER365 |
| K | ILE366 |
| K | TYR367 |
| L | LEU120 |
| L | SER121 |
| L | GLY122 |
| L | ALA156 |
| L | THR157 |
| L | VAL158 |
| L | HIS159 |
| L | HIS161 |
| site_id | BC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE COM J 1555 |
| Chain | Residue |
| J | TYR336 |
| J | PHE446 |
| J | TYR447 |
| J | F431554 |
| J | HOH2291 |
| K | PHE361 |
| K | SER365 |
| K | TYR367 |
| L | LEU120 |
| L | ARG123 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 J 1556 |
| Chain | Residue |
| G | ARG274 |
| G | LEU323 |
| G | MET327 |
| G | PHE446 |
| G | MET483 |
| G | ASN484 |
| G | VAL485 |
| G | HOH2238 |
| G | HOH2242 |
| G | HOH2245 |
| G | HOH2347 |
| G | HOH2379 |
| H | TYR367 |
| H | GLY368 |
| H | GLY369 |
| H | HIS379 |
| H | VAL380 |
| H | HOH2240 |
| J | ARG229 |
| J | LYS260 |
| J | MHS261 |
| site_id | BC3 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE F43 G 1554 |
| Chain | Residue |
| G | GLY329 |
| G | GLY330 |
| G | VAL331 |
| G | GLY332 |
| G | PHE333 |
| G | THR334 |
| G | GLN335 |
| G | TYR336 |
| G | GLY400 |
| G | GLY445 |
| G | PHE446 |
| G | COM1553 |
| G | HOH2268 |
| G | HOH2303 |
| G | HOH2381 |
| G | HOH2382 |
| G | HOH2383 |
| G | HOH2384 |
| G | HOH2385 |
| H | SER365 |
| H | ILE366 |
| H | TYR367 |
| I | LEU120 |
| I | SER121 |
| I | GLY122 |
| I | ALA156 |
| I | THR157 |
| I | VAL158 |
| I | HIS159 |
| I | HIS161 |
| J | ALA148 |
| J | VAL149 |
| J | VAL150 |
| J | GLN151 |
| J | GLN234 |
| J | MET237 |
| J | ALA247 |
| site_id | BC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ACT G 1555 |
| Chain | Residue |
| G | ASP348 |
| G | TYR351 |
| G | TYR352 |
| G | GLU355 |
| G | HOH2001 |
| G | HOH2275 |
| G | HOH2295 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1555 |
| Chain | Residue |
| A | GLU163 |
| A | ASP164 |
| A | ASP520 |
| A | HOH2100 |
| D | LYS53 |
| D | ARG54 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT D 1557 |
| Chain | Residue |
| A | LYS53 |
| A | ARG54 |
| D | GLU163 |
| D | ASP164 |
| D | ASP520 |
| site_id | BC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT J 1557 |
| Chain | Residue |
| G | LYS53 |
| G | ARG54 |
| J | GLU163 |
| J | ASP164 |
| J | ASP520 |
| J | HOH2073 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT K 1444 |
| Chain | Residue |
| G | GLU266 |
| G | ASN509 |
| G | HOH2247 |
| K | ASN67 |
| K | ARG163 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACT E 1444 |
| Chain | Residue |
| B | HOH2107 |
| E | LYS43 |
| site_id | CC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT H 1444 |
| Chain | Residue |
| C | HIS186 |
| C | GLY205 |
| C | HOH2121 |
| H | GLU83 |
| H | ASN108 |
| site_id | CC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT L 1265 |
| Chain | Residue |
| L | ASN17 |
| L | HIS21 |
| L | TYR26 |
| L | ARG29 |
| L | GLU144 |
| L | ILE216 |
| site_id | CC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT F 1265 |
| Chain | Residue |
| F | ASN17 |
| F | HIS21 |
| F | TYR26 |
| F | GLU144 |
| F | ILE216 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT I 1265 |
| Chain | Residue |
| I | ASN17 |
| I | HIS21 |
| I | TYR26 |
| I | GLU144 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT E 1445 |
| Chain | Residue |
| A | GLU266 |
| A | THR289 |
| A | ASN509 |
| A | HOH2242 |
| E | ASN67 |
| E | ARG163 |
| site_id | CC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE NA F 1270 |
| Chain | Residue |
| F | ILE225 |
| F | ALA226 |
| F | ASP229 |
