Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5A8R

METHYL-COENZYME M REDUCTASE II FROM METHANOTHERMOBACTER MARBURGENSIS AT 2.15 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015948	biological_process	methanogenesis
A	0016740	molecular_function	transferase activity
A	0046872	molecular_function	metal ion binding
A	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
B	0015948	biological_process	methanogenesis
B	0016740	molecular_function	transferase activity
B	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
C	0015948	biological_process	methanogenesis
C	0016740	molecular_function	transferase activity
C	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
D	0015948	biological_process	methanogenesis
D	0016740	molecular_function	transferase activity
D	0046872	molecular_function	metal ion binding
D	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
E	0015948	biological_process	methanogenesis
E	0016740	molecular_function	transferase activity
E	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
F	0015948	biological_process	methanogenesis
F	0016740	molecular_function	transferase activity
F	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
G	0015948	biological_process	methanogenesis
G	0016740	molecular_function	transferase activity
G	0046872	molecular_function	metal ion binding
G	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
H	0015948	biological_process	methanogenesis
H	0016740	molecular_function	transferase activity
H	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
I	0015948	biological_process	methanogenesis
I	0016740	molecular_function	transferase activity
I	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
J	0015948	biological_process	methanogenesis
J	0016740	molecular_function	transferase activity
J	0046872	molecular_function	metal ion binding
J	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
K	0015948	biological_process	methanogenesis
K	0016740	molecular_function	transferase activity
K	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity
L	0015948	biological_process	methanogenesis
L	0016740	molecular_function	transferase activity
L	0050524	molecular_function	coenzyme-B sulfoethylthiotransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE COM A 601

Chain	Residue
A	TYR335
D	F43603
A	PHE445
A	TYR446
A	HOH2286
A	HOH2287
B	PHE361
B	TYR367
C	LEU120
C	ARG123

site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE TP7 A 602

Chain	Residue
A	ARG228
A	LYS259
A	MHS260
A	HOH2138
A	HOH2288
A	HOH2289
A	HOH2290
A	HOH2291
D	ARG273
D	MET326
D	SER327
D	PHE332
D	PHE445
D	MET482
D	ASN483
D	VAL484
E	PHE362
E	TYR367
E	GLY369
E	HIS379
E	VAL380

site_id	AC3
Number of Residues	38
Details	BINDING SITE FOR RESIDUE F43 A 603

Chain	Residue
A	ALA147
A	VAL148
A	VAL149
A	GLN150
A	GLN233
A	MET236
A	ALA246
A	HOH2080
A	HOH2082
A	HOH2083
A	HOH2084
A	HOH2131
A	HOH2295
A	HOH2296
D	GLY328
D	GLY329
D	VAL330
D	GLY331
D	PHE332
D	THR333
D	GLN334
D	TYR335
D	PHE398
D	GLY399
D	GLY444
D	PHE445
D	COM601
E	SER365
E	ILE366
E	TYR367
F	LEU120
F	SER121
F	GLY122
F	ALA156
F	THR157
F	VAL158
F	HIS159
F	HIS161

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K A 604

Chain	Residue
A	PRO61
A	ILE63
A	VAL65
D	ALA147
D	HOH2064

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE COM D 601

Chain	Residue
A	F43603
A	HOH2292
D	TYR335
D	PHE445
D	TYR446
D	HOH2208
E	PHE361
E	SER365
E	TYR367
F	LEU120
F	ARG123

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE TP7 D 602

Chain	Residue
B	VAL380
B	HOH2133
D	ARG228
D	LYS259
D	MHS260
A	ARG273
A	MET326
A	PHE445
A	MET482
A	ASN483
A	VAL484
A	HOH2155
A	HOH2158
A	HOH2160
A	HOH2258
B	TYR367
B	GLY368
B	GLY369
B	HIS379

site_id	AC7
Number of Residues	38
Details	BINDING SITE FOR RESIDUE F43 D 603

Chain	Residue
A	GLY328
A	GLY329
A	VAL330
A	GLY331
A	PHE332
A	THR333
A	GLN334
A	TYR335
A	PHE398
A	GLY399
A	GLY444
A	PHE445
A	COM601
A	HOH2181
A	HOH2213
B	SER365
B	ILE366
B	TYR367
C	LEU120
C	SER121
C	GLY122
C	ALA156
C	THR157
C	VAL158
C	HIS159
C	HIS161
C	HOH2024
C	HOH2049
C	HOH2050
C	HOH2051
D	ALA147
D	VAL148
D	VAL149
D	GLN150
D	GLN233
D	MET236
D	ALA246
D	HOH2063

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K D 604

Chain	Residue
A	ALA147
A	HOH2078
D	PRO61
D	ILE63
D	VAL65

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K D 605

Chain	Residue
A	VAL218
A	ARG219
A	CYS221
D	VAL218
D	ARG219
D	CYS221

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE COM G 601

Chain	Residue
G	TYR335
G	PHE445
G	TYR446
G	F43603
G	HOH2251
G	HOH2252
H	PHE361
H	SER365
H	TYR367
I	LEU120
I	ARG123

site_id	BC2
Number of Residues	21
Details	BINDING SITE FOR RESIDUE TP7 G 602

Chain	Residue
G	ARG273
G	LEU322
G	MET326
G	SER327
G	PHE332
G	PHE445
G	MET482
G	ASN483
G	VAL484
G	HOH2145
G	HOH2147
G	HOH2150
G	HOH2231
G	HOH2253
H	TYR367
H	GLY369
H	HIS379
H	VAL380
J	ARG228
J	LYS259
J	MHS260

site_id	BC3
Number of Residues	36
Details	BINDING SITE FOR RESIDUE F43 G 603

Chain	Residue
G	GLY328
G	VAL330
G	GLY331
G	PHE332
G	THR333
G	GLN334
G	TYR335
G	GLY399
G	GLY444
G	PHE445
G	COM601
G	HOH2171
G	HOH2187
G	HOH2255
G	HOH2256
G	HOH2257
G	HOH2258
G	HOH2260
H	SER365
H	ILE366
H	TYR367
I	LEU120
I	SER121
I	GLY122
I	ALA156
I	THR157
I	VAL158
I	HIS159
I	HIS161
J	ALA147
J	VAL148
J	VAL149
J	GLN150
J	GLN233
J	MET236
J	ALA246

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K G 604

Chain	Residue
G	PRO61
G	ILE63
G	VAL65
J	ALA147
J	HOH2056

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE COM J 601

Chain	Residue
J	TYR335
J	PHE445
J	TYR446
J	F43603
J	HOH2218
J	HOH2219
K	PHE361
K	TYR367
L	LEU120
L	ARG123

site_id	BC6
Number of Residues	22
Details	BINDING SITE FOR RESIDUE TP7 J 602

Chain	Residue
G	ARG228
G	LYS259
G	MHS260
G	HOH2130
J	ARG273
J	MET326
J	SER327
J	PHE332
J	PHE445
J	MET482
J	ASN483
J	VAL484
J	HOH2110
J	HOH2113
J	HOH2115
J	HOH2202
K	PHE362
K	TYR367
K	GLY368
K	GLY369
K	HIS379
K	VAL380

site_id	BC7
Number of Residues	38
Details	BINDING SITE FOR RESIDUE F43 J 603

Chain	Residue
G	ALA147
G	VAL148
G	VAL149
G	GLN150
G	GLN233
G	MET236
G	ALA246
G	HOH2068
G	HOH2070
G	HOH2071
G	HOH2072
G	HOH2123
J	GLY328
J	GLY329
J	VAL330
J	GLY331
J	PHE332
J	THR333
J	GLN334
J	TYR335
J	PHE398
J	GLY399
J	GLY444
J	PHE445
J	COM601
J	HOH2163
J	HOH2220
K	SER365
K	ILE366
K	TYR367
L	LEU120
L	SER121
L	GLY122
L	ALA156
L	THR157
L	VAL158
L	HIS159
L	HIS161

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K J 604

Chain	Residue
G	VAL218
G	ARG219
G	CYS221
J	VAL218
J	ARG219
J	CYS221

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K J 605

Chain	Residue
G	ALA147
G	HOH2074
J	PRO61
J	ILE63
J	VAL65

site_id	CC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K J 606

Chain	Residue
F	ASP25
F	HOH2004
J	ASN188
J	LYS189
J	PHE191
J	HOH2075
J	HOH2078

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A8R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"in chain A","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A8R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"description":"in chain B","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A8R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	20
Details	Binding site: {"evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A8R","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Pros-methylhistidine","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"5-methylarginine","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"2-methylglutamine","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"1-thioglycine","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Modified residue: {"description":"(Z)-2,3-didehydroaspartate","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Modified residue: {"description":"S-methylcysteine","evidences":[{"source":"PubMed","id":"27467699","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)