5A8R
METHYL-COENZYME M REDUCTASE II FROM METHANOTHERMOBACTER MARBURGENSIS AT 2.15 A RESOLUTION
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015948 | biological_process | methanogenesis |
| A | 0016740 | molecular_function | transferase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| B | 0015948 | biological_process | methanogenesis |
| B | 0016740 | molecular_function | transferase activity |
| B | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016740 | molecular_function | transferase activity |
| C | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| D | 0015948 | biological_process | methanogenesis |
| D | 0016740 | molecular_function | transferase activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| E | 0015948 | biological_process | methanogenesis |
| E | 0016740 | molecular_function | transferase activity |
| E | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| F | 0015948 | biological_process | methanogenesis |
| F | 0016740 | molecular_function | transferase activity |
| F | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| G | 0015948 | biological_process | methanogenesis |
| G | 0016740 | molecular_function | transferase activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| H | 0015948 | biological_process | methanogenesis |
| H | 0016740 | molecular_function | transferase activity |
| H | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| I | 0015948 | biological_process | methanogenesis |
| I | 0016740 | molecular_function | transferase activity |
| I | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| J | 0015948 | biological_process | methanogenesis |
| J | 0016740 | molecular_function | transferase activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| K | 0015948 | biological_process | methanogenesis |
| K | 0016740 | molecular_function | transferase activity |
| K | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
| L | 0015948 | biological_process | methanogenesis |
| L | 0016740 | molecular_function | transferase activity |
| L | 0050524 | molecular_function | coenzyme-B sulfoethylthiotransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE COM A 601 |
| Chain | Residue |
| A | TYR335 |
| D | F43603 |
| A | PHE445 |
| A | TYR446 |
| A | HOH2286 |
| A | HOH2287 |
| B | PHE361 |
| B | TYR367 |
| C | LEU120 |
| C | ARG123 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 A 602 |
| Chain | Residue |
| A | ARG228 |
| A | LYS259 |
| A | MHS260 |
| A | HOH2138 |
| A | HOH2288 |
| A | HOH2289 |
| A | HOH2290 |
| A | HOH2291 |
| D | ARG273 |
| D | MET326 |
| D | SER327 |
| D | PHE332 |
| D | PHE445 |
| D | MET482 |
| D | ASN483 |
| D | VAL484 |
| E | PHE362 |
| E | TYR367 |
| E | GLY369 |
| E | HIS379 |
| E | VAL380 |
| site_id | AC3 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 A 603 |
| Chain | Residue |
| A | ALA147 |
| A | VAL148 |
| A | VAL149 |
| A | GLN150 |
| A | GLN233 |
| A | MET236 |
| A | ALA246 |
| A | HOH2080 |
| A | HOH2082 |
| A | HOH2083 |
| A | HOH2084 |
| A | HOH2131 |
| A | HOH2295 |
| A | HOH2296 |
| D | GLY328 |
| D | GLY329 |
| D | VAL330 |
| D | GLY331 |
| D | PHE332 |
| D | THR333 |
| D | GLN334 |
| D | TYR335 |
| D | PHE398 |
| D | GLY399 |
| D | GLY444 |
| D | PHE445 |
| D | COM601 |
| E | SER365 |
| E | ILE366 |
| E | TYR367 |
| F | LEU120 |
| F | SER121 |
| F | GLY122 |
| F | ALA156 |
| F | THR157 |
| F | VAL158 |
| F | HIS159 |
| F | HIS161 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 604 |
| Chain | Residue |
| A | PRO61 |
| A | ILE63 |
| A | VAL65 |
| D | ALA147 |
| D | HOH2064 |
| site_id | AC5 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE COM D 601 |
| Chain | Residue |
| A | F43603 |
| A | HOH2292 |
| D | TYR335 |
| D | PHE445 |
| D | TYR446 |
| D | HOH2208 |
| E | PHE361 |
| E | SER365 |
| E | TYR367 |
| F | LEU120 |
| F | ARG123 |
| site_id | AC6 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE TP7 D 602 |
| Chain | Residue |
| B | VAL380 |
| B | HOH2133 |
| D | ARG228 |
| D | LYS259 |
| D | MHS260 |
| A | ARG273 |
| A | MET326 |
| A | PHE445 |
| A | MET482 |
| A | ASN483 |
| A | VAL484 |
| A | HOH2155 |
| A | HOH2158 |
| A | HOH2160 |
| A | HOH2258 |
| B | TYR367 |
| B | GLY368 |
| B | GLY369 |
| B | HIS379 |
| site_id | AC7 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 D 603 |
| Chain | Residue |
| A | GLY328 |
| A | GLY329 |
| A | VAL330 |
| A | GLY331 |
| A | PHE332 |
| A | THR333 |
| A | GLN334 |
| A | TYR335 |
| A | PHE398 |
| A | GLY399 |
| A | GLY444 |
| A | PHE445 |
| A | COM601 |
| A | HOH2181 |
| A | HOH2213 |
| B | SER365 |
| B | ILE366 |
| B | TYR367 |
| C | LEU120 |
| C | SER121 |
| C | GLY122 |
| C | ALA156 |
| C | THR157 |
| C | VAL158 |
| C | HIS159 |
| C | HIS161 |
| C | HOH2024 |
| C | HOH2049 |
| C | HOH2050 |
| C | HOH2051 |
| D | ALA147 |
| D | VAL148 |
| D | VAL149 |
| D | GLN150 |
| D | GLN233 |
| D | MET236 |
| D | ALA246 |
| D | HOH2063 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 604 |
| Chain | Residue |
| A | ALA147 |
| A | HOH2078 |
| D | PRO61 |
| D | ILE63 |
| D | VAL65 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 605 |
| Chain | Residue |
| A | VAL218 |
| A | ARG219 |
| A | CYS221 |
| D | VAL218 |
| D | ARG219 |
| D | CYS221 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE COM G 601 |
| Chain | Residue |
| G | TYR335 |
| G | PHE445 |
| G | TYR446 |
| G | F43603 |
| G | HOH2251 |
| G | HOH2252 |
| H | PHE361 |
| H | SER365 |
| H | TYR367 |
| I | LEU120 |
| I | ARG123 |
| site_id | BC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE TP7 G 602 |
| Chain | Residue |
| G | ARG273 |
| G | LEU322 |
| G | MET326 |
| G | SER327 |
| G | PHE332 |
| G | PHE445 |
| G | MET482 |
| G | ASN483 |
| G | VAL484 |
| G | HOH2145 |
| G | HOH2147 |
| G | HOH2150 |
| G | HOH2231 |
| G | HOH2253 |
| H | TYR367 |
| H | GLY369 |
| H | HIS379 |
| H | VAL380 |
| J | ARG228 |
| J | LYS259 |
| J | MHS260 |
| site_id | BC3 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE F43 G 603 |
| Chain | Residue |
| G | GLY328 |
| G | VAL330 |
| G | GLY331 |
| G | PHE332 |
| G | THR333 |
| G | GLN334 |
| G | TYR335 |
| G | GLY399 |
| G | GLY444 |
| G | PHE445 |
| G | COM601 |
| G | HOH2171 |
| G | HOH2187 |
| G | HOH2255 |
| G | HOH2256 |
| G | HOH2257 |
| G | HOH2258 |
| G | HOH2260 |
| H | SER365 |
| H | ILE366 |
| H | TYR367 |
| I | LEU120 |
| I | SER121 |
| I | GLY122 |
| I | ALA156 |
| I | THR157 |
| I | VAL158 |
| I | HIS159 |
| I | HIS161 |
| J | ALA147 |
| J | VAL148 |
| J | VAL149 |
| J | GLN150 |
| J | GLN233 |
| J | MET236 |
| J | ALA246 |
| site_id | BC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K G 604 |
| Chain | Residue |
| G | PRO61 |
| G | ILE63 |
| G | VAL65 |
| J | ALA147 |
| J | HOH2056 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE COM J 601 |
| Chain | Residue |
| J | TYR335 |
| J | PHE445 |
| J | TYR446 |
| J | F43603 |
| J | HOH2218 |
| J | HOH2219 |
| K | PHE361 |
| K | TYR367 |
| L | LEU120 |
| L | ARG123 |
| site_id | BC6 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE TP7 J 602 |
| Chain | Residue |
| G | ARG228 |
| G | LYS259 |
| G | MHS260 |
| G | HOH2130 |
| J | ARG273 |
| J | MET326 |
| J | SER327 |
| J | PHE332 |
| J | PHE445 |
| J | MET482 |
| J | ASN483 |
| J | VAL484 |
| J | HOH2110 |
| J | HOH2113 |
| J | HOH2115 |
| J | HOH2202 |
| K | PHE362 |
| K | TYR367 |
| K | GLY368 |
| K | GLY369 |
| K | HIS379 |
| K | VAL380 |
| site_id | BC7 |
| Number of Residues | 38 |
| Details | BINDING SITE FOR RESIDUE F43 J 603 |
| Chain | Residue |
| G | ALA147 |
| G | VAL148 |
| G | VAL149 |
| G | GLN150 |
| G | GLN233 |
| G | MET236 |
| G | ALA246 |
| G | HOH2068 |
| G | HOH2070 |
| G | HOH2071 |
| G | HOH2072 |
| G | HOH2123 |
| J | GLY328 |
| J | GLY329 |
| J | VAL330 |
| J | GLY331 |
| J | PHE332 |
| J | THR333 |
| J | GLN334 |
| J | TYR335 |
| J | PHE398 |
| J | GLY399 |
| J | GLY444 |
| J | PHE445 |
| J | COM601 |
| J | HOH2163 |
| J | HOH2220 |
| K | SER365 |
| K | ILE366 |
| K | TYR367 |
| L | LEU120 |
| L | SER121 |
| L | GLY122 |
| L | ALA156 |
| L | THR157 |
| L | VAL158 |
| L | HIS159 |
| L | HIS161 |
| site_id | BC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K J 604 |
| Chain | Residue |
| G | VAL218 |
| G | ARG219 |
| G | CYS221 |
| J | VAL218 |
| J | ARG219 |
| J | CYS221 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K J 605 |
| Chain | Residue |
| G | ALA147 |
| G | HOH2074 |
| J | PRO61 |
| J | ILE63 |
| J | VAL65 |
| site_id | CC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K J 606 |
| Chain | Residue |
| F | ASP25 |
| F | HOH2004 |
| J | ASN188 |
| J | LYS189 |
| J | PHE191 |
| J | HOH2075 |
| J | HOH2078 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27467699, ECO:0007744|PDB:5A8R |
| Chain | Residue | Details |
| H | TYR367 | |
| H | GLY369 | |
| K | TYR367 | |
| K | GLY369 | |
| C | ARG123 | |
| F | ARG123 | |
| I | ARG123 | |
| L | ARG123 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:27467699, ECO:0007744|PDB:5A8R |
| Chain | Residue | Details |
| G | ARG228 | |
| G | LYS259 | |
| J | ARG228 | |
| J | LYS259 | |
| A | ARG228 | |
| A | LYS259 | |
| D | ARG228 | |
| D | LYS259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:27467699, ECO:0007744|PDB:5A8R |
| Chain | Residue | Details |
| A | ARG273 | |
| D | ARG273 | |
| G | ARG273 | |
| J | ARG273 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27467699, ECO:0007744|PDB:5A8R |
| Chain | Residue | Details |
| G | TYR335 | |
| G | TYR446 | |
| J | TYR335 | |
| J | TYR446 | |
| A | TYR335 | |
| A | TYR446 | |
| D | TYR335 | |
| D | TYR446 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Pros-methylhistidine => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| D | MHS260 | |
| A | MHS260 | |
| G | MHS260 | |
| J | MHS260 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | MOD_RES: 5-methylarginine => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| D | AGM274 | |
| A | AGM274 | |
| G | AGM274 | |
| J | AGM274 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: 2-methylglutamine => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| D | MGN402 | |
| A | MGN402 | |
| G | MGN402 | |
| J | MGN402 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | MOD_RES: 1-thioglycine => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| D | GL3447 | |
| A | GL3447 | |
| G | GL3447 | |
| J | GL3447 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 4 |
| Details | MOD_RES: (Z)-2,3-didehydroaspartate => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| D | DYA452 | |
| A | DYA452 | |
| G | DYA452 | |
| J | DYA452 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | MOD_RES: S-methylcysteine => ECO:0000269|PubMed:27467699 |
| Chain | Residue | Details |
| A | SMC454 | |
| D | SMC454 | |
| G | SMC454 | |
| J | SMC454 |
