5A8L

Human eRF1 and the hCMV nascent peptide in the translation termination complex

Functional Information from GO Data

Chain	GOid	namespace	contents
D	0002181	biological_process	cytoplasmic translation
D	0003723	molecular_function	RNA binding
D	0003735	molecular_function	structural constituent of ribosome
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005840	cellular_component	ribosome
D	0006412	biological_process	translation
D	0015934	cellular_component	large ribosomal subunit
D	0022625	cellular_component	cytosolic large ribosomal subunit
D	0022626	cellular_component	cytosolic ribosome
D	1990904	cellular_component	ribonucleoprotein complex
G	0002181	biological_process	cytoplasmic translation
G	0003723	molecular_function	RNA binding
G	0003735	molecular_function	structural constituent of ribosome
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005840	cellular_component	ribosome
G	0005925	cellular_component	focal adhesion
G	0006412	biological_process	translation
G	0014069	cellular_component	postsynaptic density
G	0016020	cellular_component	membrane
G	0022625	cellular_component	cytosolic large ribosomal subunit
G	0022626	cellular_component	cytosolic ribosome
G	0070062	cellular_component	extracellular exosome
G	0070180	molecular_function	large ribosomal subunit rRNA binding
G	1990904	cellular_component	ribonucleoprotein complex
H	0002181	biological_process	cytoplasmic translation
H	0003723	molecular_function	RNA binding
H	0003735	molecular_function	structural constituent of ribosome
H	0005515	molecular_function	protein binding
H	0005634	cellular_component	nucleus
H	0005730	cellular_component	nucleolus
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005791	cellular_component	rough endoplasmic reticulum
H	0005829	cellular_component	cytosol
H	0005840	cellular_component	ribosome
H	0005925	cellular_component	focal adhesion
H	0006412	biological_process	translation
H	0016020	cellular_component	membrane
H	0016604	cellular_component	nuclear body
H	0022625	cellular_component	cytosolic large ribosomal subunit
H	0022626	cellular_component	cytosolic ribosome
H	0070062	cellular_component	extracellular exosome
H	1990904	cellular_component	ribonucleoprotein complex
Q	0000184	biological_process	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Q	0002184	biological_process	cytoplasmic translational termination
Q	0003723	molecular_function	RNA binding
Q	0003747	molecular_function	translation release factor activity
Q	0004045	molecular_function	peptidyl-tRNA hydrolase activity
Q	0005515	molecular_function	protein binding
Q	0005634	cellular_component	nucleus
Q	0005737	cellular_component	cytoplasm
Q	0005829	cellular_component	cytosol
Q	0006412	biological_process	translation
Q	0006415	biological_process	translational termination
Q	0006449	biological_process	regulation of translational termination
Q	0006479	biological_process	protein methylation
Q	0008079	molecular_function	translation termination factor activity
Q	0016149	molecular_function	translation release factor activity, codon specific
Q	0018444	cellular_component	translation release factor complex
Q	0022626	cellular_component	cytosolic ribosome
Q	0032790	biological_process	ribosome disassembly
Q	0043022	molecular_function	ribosome binding
Q	1990825	molecular_function	sequence-specific mRNA binding

Functional Information from PROSITE/UniProt

site_id	PS00359
Number of Residues	16
Details	RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG

Chain	Residue	Details
G	LYS130-GLY145

---

site_id	PS00464
Number of Residues	25
Details	RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL

Chain	Residue	Details
D	ARG126-LEU150

---

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV

Chain	Residue	Details
H	GLY15-VAL22

---

site_id	PS00939
Number of Residues	27
Details	RIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH

Chain	Residue	Details
H	ASN116-HIS142

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36638793","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Motif: {"description":"NIKS motif; plays an important role in translational termination","evidences":[{"source":"PubMed","id":"24486019","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"4-hydroxylysine","evidences":[{"source":"PubMed","id":"24486019","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"18539146","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20606008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26797129","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37651229","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---