5A8L
Human eRF1 and the hCMV nascent peptide in the translation termination complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| D | 0002181 | biological_process | cytoplasmic translation |
| D | 0003723 | molecular_function | RNA binding |
| D | 0003735 | molecular_function | structural constituent of ribosome |
| D | 0005515 | molecular_function | protein binding |
| D | 0005634 | cellular_component | nucleus |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0005840 | cellular_component | ribosome |
| D | 0006412 | biological_process | translation |
| D | 0015934 | cellular_component | large ribosomal subunit |
| D | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| D | 0022626 | cellular_component | cytosolic ribosome |
| D | 1990904 | cellular_component | ribonucleoprotein complex |
| G | 0002181 | biological_process | cytoplasmic translation |
| G | 0003723 | molecular_function | RNA binding |
| G | 0003735 | molecular_function | structural constituent of ribosome |
| G | 0005515 | molecular_function | protein binding |
| G | 0005634 | cellular_component | nucleus |
| G | 0005730 | cellular_component | nucleolus |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005829 | cellular_component | cytosol |
| G | 0005840 | cellular_component | ribosome |
| G | 0005925 | cellular_component | focal adhesion |
| G | 0006412 | biological_process | translation |
| G | 0014069 | cellular_component | postsynaptic density |
| G | 0016020 | cellular_component | membrane |
| G | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| G | 0022626 | cellular_component | cytosolic ribosome |
| G | 0045202 | cellular_component | synapse |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0070180 | molecular_function | large ribosomal subunit rRNA binding |
| G | 1990904 | cellular_component | ribonucleoprotein complex |
| H | 0002181 | biological_process | cytoplasmic translation |
| H | 0003723 | molecular_function | RNA binding |
| H | 0003735 | molecular_function | structural constituent of ribosome |
| H | 0005515 | molecular_function | protein binding |
| H | 0005634 | cellular_component | nucleus |
| H | 0005730 | cellular_component | nucleolus |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0005791 | cellular_component | rough endoplasmic reticulum |
| H | 0005829 | cellular_component | cytosol |
| H | 0005840 | cellular_component | ribosome |
| H | 0005925 | cellular_component | focal adhesion |
| H | 0006412 | biological_process | translation |
| H | 0016020 | cellular_component | membrane |
| H | 0022625 | cellular_component | cytosolic large ribosomal subunit |
| H | 0022626 | cellular_component | cytosolic ribosome |
| H | 0070062 | cellular_component | extracellular exosome |
| H | 1990904 | cellular_component | ribonucleoprotein complex |
| Q | 0000184 | biological_process | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay |
| Q | 0002184 | biological_process | cytoplasmic translational termination |
| Q | 0003723 | molecular_function | RNA binding |
| Q | 0003747 | molecular_function | translation release factor activity |
| Q | 0004045 | molecular_function | aminoacyl-tRNA hydrolase activity |
| Q | 0005515 | molecular_function | protein binding |
| Q | 0005634 | cellular_component | nucleus |
| Q | 0005737 | cellular_component | cytoplasm |
| Q | 0005829 | cellular_component | cytosol |
| Q | 0006412 | biological_process | translation |
| Q | 0006415 | biological_process | translational termination |
| Q | 0006449 | biological_process | regulation of translational termination |
| Q | 0006479 | biological_process | protein methylation |
| Q | 0008079 | molecular_function | translation termination factor activity |
| Q | 0016149 | molecular_function | translation release factor activity, codon specific |
| Q | 0018444 | cellular_component | translation release factor complex |
| Q | 0022626 | cellular_component | cytosolic ribosome |
| Q | 0043022 | molecular_function | ribosome binding |
| Q | 1990825 | molecular_function | sequence-specific mRNA binding |
Functional Information from PROSITE/UniProt
| site_id | PS00359 |
| Number of Residues | 16 |
| Details | RIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG |
| Chain | Residue | Details |
| G | LYS130-GLY145 |
| site_id | PS00464 |
| Number of Residues | 25 |
| Details | RIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL |
| Chain | Residue | Details |
| D | ARG126-LEU150 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV |
| Chain | Residue | Details |
| H | GLY15-VAL22 |
| site_id | PS00939 |
| Number of Residues | 27 |
| Details | RIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH |
| Chain | Residue | Details |
| H | ASN116-HIS142 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: 4-hydroxylysine => ECO:0000269|PubMed:24486019 |
| Chain | Residue | Details |
| Q | LYS63 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: N5-methylglutamine => ECO:0000269|PubMed:18539146, ECO:0000269|PubMed:20606008, ECO:0000269|PubMed:26797129 |
| Chain | Residue | Details |
| Q | GLN185 | |
| H | LYS106 | |
| H | LYS333 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| Q | THR347 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| Q | LYS87 | |
| H | LYS353 | |
| Q | LYS404 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:37651229 |
| Chain | Residue | Details |
| Q | LYS279 | |
| G | LYS48 | |
| G | LYS83 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P50878 |
| Chain | Residue | Details |
| H | SER290 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| H | SER295 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Citrulline => ECO:0000250|UniProtKB:Q9D8E6 |
| Chain | Residue | Details |
| H | ARG300 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q9D8E6 |
| Chain | Residue | Details |
| H | LYS364 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231 |
| Chain | Residue | Details |
| H | SER365 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| H | LYS239 | |
| H | LYS327 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211 |
| Chain | Residue | Details |
| H | LYS364 |
