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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

5A8L

Human eRF1 and the hCMV nascent peptide in the translation termination complex

Functional Information from GO Data
ChainGOidnamespacecontents
D0002181biological_processcytoplasmic translation
D0003723molecular_functionRNA binding
D0003735molecular_functionstructural constituent of ribosome
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005840cellular_componentribosome
D0006412biological_processtranslation
D0006941biological_processstriated muscle contraction
D0007283biological_processspermatogenesis
D0015934cellular_componentlarge ribosomal subunit
D0022625cellular_componentcytosolic large ribosomal subunit
D0022626cellular_componentcytosolic ribosome
D1901740biological_processnegative regulation of myoblast fusion
D1990904cellular_componentribonucleoprotein complex
G0002181biological_processcytoplasmic translation
G0003723molecular_functionRNA binding
G0003735molecular_functionstructural constituent of ribosome
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005840cellular_componentribosome
G0005925cellular_componentfocal adhesion
G0006412biological_processtranslation
G0006941biological_processstriated muscle contraction
G0007283biological_processspermatogenesis
G0014069cellular_componentpostsynaptic density
G0016020cellular_componentmembrane
G0022625cellular_componentcytosolic large ribosomal subunit
G0022626cellular_componentcytosolic ribosome
G0070062cellular_componentextracellular exosome
G0070180molecular_functionlarge ribosomal subunit rRNA binding
G1901740biological_processnegative regulation of myoblast fusion
G1990904cellular_componentribonucleoprotein complex
H0002181biological_processcytoplasmic translation
H0003723molecular_functionRNA binding
H0003735molecular_functionstructural constituent of ribosome
H0005515molecular_functionprotein binding
H0005634cellular_componentnucleus
H0005730cellular_componentnucleolus
H0005737cellular_componentcytoplasm
H0005791cellular_componentrough endoplasmic reticulum
H0005829cellular_componentcytosol
H0005840cellular_componentribosome
H0005925cellular_componentfocal adhesion
H0006412biological_processtranslation
H0006941biological_processstriated muscle contraction
H0007283biological_processspermatogenesis
H0016020cellular_componentmembrane
H0022625cellular_componentcytosolic large ribosomal subunit
H0022626cellular_componentcytosolic ribosome
H0070062cellular_componentextracellular exosome
H1901740biological_processnegative regulation of myoblast fusion
H1990904cellular_componentribonucleoprotein complex
Q0000184biological_processnuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Q0002184biological_processcytoplasmic translational termination
Q0003723molecular_functionRNA binding
Q0003747molecular_functiontranslation release factor activity
Q0004045molecular_functionpeptidyl-tRNA hydrolase activity
Q0005515molecular_functionprotein binding
Q0005634cellular_componentnucleus
Q0005737cellular_componentcytoplasm
Q0005829cellular_componentcytosol
Q0006412biological_processtranslation
Q0006415biological_processtranslational termination
Q0006449biological_processregulation of translational termination
Q0006479biological_processprotein methylation
Q0008079molecular_functiontranslation termination factor activity
Q0016149molecular_functiontranslation release factor activity, codon specific
Q0018444cellular_componenttranslation release factor complex
Q0022626cellular_componentcytosolic ribosome
Q0043022molecular_functionribosome binding
Q1990825molecular_functionsequence-specific mRNA binding
Functional Information from PROSITE/UniProt
site_idPS00359
Number of Residues16
DetailsRIBOSOMAL_L11 Ribosomal protein L11 signature. KeIlGTaqSVGcNVdG
ChainResidueDetails
GLYS130-GLY145
site_idPS00464
Number of Residues25
DetailsRIBOSOMAL_L22 Ribosomal protein L22 signature. RrrTyRAhGRinpymsspCHIEMiL
ChainResidueDetails
DARG126-LEU150
site_idPS00687
Number of Residues8
DetailsALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. GESSGKNV
ChainResidueDetails
HGLY15-VAL22
site_idPS00939
Number of Residues27
DetailsRIBOSOMAL_L1E Ribosomal protein L1e signature. NttqKryAIcSALaASAlpalvmsKGH
ChainResidueDetails
HASN116-HIS142
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18691976","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"21406692","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues1
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues4
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"36638793","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues3
DetailsMotif: {"description":"NIKS motif; plays an important role in translational termination","evidences":[{"source":"PubMed","id":"24486019","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"4-hydroxylysine","evidences":[{"source":"PubMed","id":"24486019","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"N5-methylglutamine","evidences":[{"source":"PubMed","id":"18539146","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20606008","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26797129","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"37651229","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

245663

PDB entries from 2025-12-03

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