5A8E

thermostabilised beta1-adrenoceptor with rationally designed inverse agonist 7-methylcyanopindolol bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0004935	molecular_function	adrenergic receptor activity
A	0004940	molecular_function	beta1-adrenergic receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007189	biological_process	adenylate cyclase-activating G protein-coupled receptor signaling pathway
A	0016020	cellular_component	membrane
A	0045823	biological_process	positive regulation of heart contraction

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 401

Chain	Residue
A	CYS192
A	ASP195
A	CYS198
A	HOH3009
A	HOH3014
A	HOH3015

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA A 402

Chain	Residue
A	HOH3004
A	HOH3022
A	ASP87
A	SER128
A	HOH3003

---

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE XTK A 501

Chain	Residue
A	TRP117
A	ASP121
A	VAL122
A	THR203
A	ALA208
A	SER211
A	SER215
A	TRP303
A	PHE306
A	PHE307
A	ASN310
A	ASN329
A	TYR333

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MHA A 801

Chain	Residue
A	GLY110
A	SER111
A	PRO196
A	LYS287
A	LYS290
A	THR291
A	ARG345
A	SER346
A	HOH3008
A	HOH3026

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE OLC A 2001

Chain	Residue
A	ALA227
A	ILE238
A	ARG239
A	HIS286
A	LEU289
A	GLY293
A	OLC2002

---

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE OLC A 2002

Chain	Residue
A	TRP107
A	LEU108
A	ASP195
A	GLY197
A	LYS287
A	LYS290
A	GLY293
A	OLC2001

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE OLC A 2003

Chain	Residue
A	TYR140
A	TYR140

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE OLC A 2004

Chain	Residue
A	GLN73
A	THR74
A	LEU75
A	THR76
A	ARG139
A	ILE143
A	ARG155
A	GLU285
A	ALA288

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE OLC A 2005

Chain	Residue
A	TRP181
A	ASP184
A	ASN204
A	ARG205
A	LYS276
A	PHE315

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVwTLCVIAIDRYLaI

Chain	Residue	Details
A	ALA127-ILE143

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	TRANSMEM: Helical; Name=1

Chain	Residue	Details
A	GLN39-GLY67

---

site_id	SWS_FT_FI2
Number of Residues	78
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18594507

Chain	Residue	Details
A	SER68-THR76
A	ASP138-ARG155
A	ARG232-ASN313

---

site_id	SWS_FT_FI3
Number of Residues	26
Details	TRANSMEM: Helical; Name=2

Chain	Residue	Details
A	ASN77-VAL103

---

site_id	SWS_FT_FI4
Number of Residues	40
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:18594507

Chain	Residue	Details
A	ARG104-GLU115
A	HIS180-ARG205
A	CYS344-ASP348

---

site_id	SWS_FT_FI5
Number of Residues	21
Details	TRANSMEM: Helical; Name=3

Chain	Residue	Details
A	LEU116-ILE137

---

site_id	SWS_FT_FI6
Number of Residues	23
Details	TRANSMEM: Helical; Name=4

Chain	Residue	Details
A	ALA156-MET179

---

site_id	SWS_FT_FI7
Number of Residues	25
Details	TRANSMEM: Helical; Name=5

Chain	Residue	Details
A	ALA206-TYR231

---

site_id	SWS_FT_FI8
Number of Residues	29
Details	TRANSMEM: Helical; Name=6

Chain	Residue	Details
A	VAL314-LEU343

---

site_id	SWS_FT_FI9
Number of Residues	22
Details	TRANSMEM: Helical; Name=7

Chain	Residue	Details
A	PHE349-HIS371

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:18594507, ECO:0007744|PDB:2VT4

Chain	Residue	Details
A	ASP121
A	SER211
A	LEU357

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	LIPID: S-palmitoyl cysteine => ECO:0000250

Chain

Residue

Details

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