5A82
Crystal structure of human ATAD2 bromodomain in complex with 4-(3R,4R) -4-(3-methyl-2-oxo-1,2-dihydro-1,7-naphthyridin-8-yl)aminopiperidin-3- yloxymethyl)-1-thiane-1,1-dione
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006325 | biological_process | chromatin organization |
| A | 0006355 | biological_process | regulation of transcription, DNA-templated |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2109 |
| Chain | Residue |
| A | GLU1091 |
| A | GLU1092 |
| A | ASP1094 |
| A | HOH3176 |
| A | HOH3191 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 2110 |
| Chain | Residue |
| A | HOH3176 |
| A | HOH3192 |
| A | HOH3193 |
| A | GLU988 |
| A | GLU1092 |
| A | LEU1093 |
| A | ASP1094 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE EDO A 2111 |
| Chain | Residue |
| A | VAL1008 |
| A | LYS1011 |
| A | VAL1013 |
| A | ASP1014 |
| A | GLU1017 |
| A | YEJ2112 |
| A | HOH3077 |
| site_id | AC4 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE YEJ A 2112 |
| Chain | Residue |
| A | ARG1007 |
| A | VAL1008 |
| A | VAL1013 |
| A | GLU1017 |
| A | TYR1063 |
| A | ASN1064 |
| A | GLY1070 |
| A | ASP1071 |
| A | ILE1074 |
| A | ARG1077 |
| A | EDO2111 |
| A | HOH3090 |
| A | HOH3194 |
| A | HOH3196 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 2113 |
| Chain | Residue |
| A | ARG987 |
| A | ARG990 |
| A | ARG994 |
| A | ARG1067 |
| A | ARG1072 |
| A | HOH3055 |
| A | HOH3144 |
