5A81

Crystal structure of human ATAD2 bromodomain in complex with 8-(3R,4R) -3-(cyclohexylmethoxy)piperidin-4-yl-amino-3-methyl-1,2-dihydro-1,7- naphthyridin-2-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006325	biological_process	chromatin organization
A	0006355	biological_process	regulation of transcription, DNA-templated
A	0016887	molecular_function	ATP hydrolysis activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 2109

Chain	Residue
A	GLU1091
A	GLU1092
A	HOH3190
A	HOH3202
A	HOH3203

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 2110

Chain	Residue
A	HOH3202
A	HOH3204
A	GLU988
A	GLU1092
A	LEU1093
A	ASP1094

---

site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 78J A 2111

Chain	Residue
A	VAL1008
A	VAL1013
A	ASN1064
A	GLY1070
A	ASP1071
A	ILE1074
A	ARG1077
A	SO42112
A	HOH3096
A	HOH3160

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 2112

Chain	Residue
A	ARG1077
A	78J2111
A	HOH3084
A	HOH3194

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 2113

Chain	Residue
A	ARG987
A	ARG990
A	ARG994
A	ARG1067
A	ARG1072
A	HOH3060
A	HOH3157

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