5A4J
Crystal structure of FTHFS1 from T.acetoxydans Re1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016874 | molecular_function | ligase activity |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| B | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016874 | molecular_function | ligase activity |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| D | 0004329 | molecular_function | formate-tetrahydrofolate ligase activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0016874 | molecular_function | ligase activity |
| D | 0035999 | biological_process | tetrahydrofolate interconversion |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1560 |
| Chain | Residue |
| A | ARG96 |
| A | ALA275 |
| A | GLY302 |
| A | PHE303 |
| A | GOL1565 |
| A | HOH2236 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1561 |
| Chain | Residue |
| A | THR534 |
| A | HOH2161 |
| A | HOH2178 |
| A | LYS166 |
| A | ARG177 |
| A | PHE178 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1562 |
| Chain | Residue |
| A | ASP43 |
| A | TYR44 |
| A | ASN45 |
| A | LYS251 |
| A | LYS255 |
| B | ASN552 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PEG A 1563 |
| Chain | Residue |
| A | THR370 |
| A | PRO376 |
| A | GLY433 |
| A | LYS434 |
| A | HOH2286 |
| A | HOH2300 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE TAR A 1564 |
| Chain | Residue |
| A | ARG174 |
| A | ARG177 |
| B | TYR151 |
| B | ALA187 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 1565 |
| Chain | Residue |
| A | LYS73 |
| A | THR74 |
| A | GLY302 |
| A | PHE303 |
| A | EDO1560 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL A 1566 |
| Chain | Residue |
| A | GLN383 |
| A | PRO385 |
| A | TRP412 |
| B | GLU479 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1560 |
| Chain | Residue |
| B | ARG96 |
| B | PHE274 |
| B | ALA275 |
| B | PHE303 |
| B | HOH2203 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1561 |
| Chain | Residue |
| B | ALA10 |
| B | VAL119 |
| B | PRO120 |
| B | MET121 |
| B | GLU122 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO B 1562 |
| Chain | Residue |
| B | PRO376 |
| B | THR377 |
| B | GLY403 |
| B | GLY433 |
| B | HOH2303 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 1563 |
| Chain | Residue |
| B | TYR228 |
| B | HOH2117 |
| B | HOH2120 |
| B | HOH2304 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE ACT B 1564 |
| Chain | Residue |
| A | ALA187 |
| B | ARG174 |
| B | ARG177 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TAR B 1565 |
| Chain | Residue |
| A | ARG541 |
| B | ASP444 |
| B | MET445 |
| B | GLY446 |
| B | ASP449 |
| B | HOH2258 |
| site_id | BC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE TAR C 1560 |
| Chain | Residue |
| C | TYR151 |
| C | ALA187 |
| C | HOH2063 |
| C | HOH2150 |
| D | ARG174 |
| D | ARG177 |
| site_id | BC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE GOL C 1561 |
| Chain | Residue |
| C | ARG174 |
| C | ARG177 |
| D | ALA187 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE GOL D 1560 |
| Chain | Residue |
| D | GLY72 |
| D | LYS73 |
| D | THR74 |
| D | PHE303 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K B 1566 |
| Chain | Residue |
| B | GLU97 |
| B | PRO98 |
| B | ILE124 |
| B | LEU126 |
| B | HOH2074 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K A 1567 |
| Chain | Residue |
| A | GLU97 |
| A | PRO98 |
| A | ILE124 |
| A | LEU126 |
| A | HOH2092 |
| site_id | CC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K D 1561 |
| Chain | Residue |
| D | ILE163 |
| D | GLU193 |
| D | HOH2058 |
| D | HOH2059 |
| D | HOH2060 |
| D | HOH2080 |
| site_id | CC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE K A 1568 |
| Chain | Residue |
| A | HOH2154 |
| A | HOH2155 |
| A | ILE163 |
| A | GLU193 |
| A | HOH2047 |
| A | HOH2145 |
| A | HOH2148 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 1562 |
| Chain | Residue |
| C | ILE163 |
| C | GLU193 |
| C | HOH2016 |
| C | HOH2068 |
| C | HOH2069 |
| C | HOH2071 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE K D 1562 |
| Chain | Residue |
| D | GLU97 |
| D | PRO98 |
| D | ILE124 |
| D | LEU126 |
| D | HOH2032 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K C 1563 |
| Chain | Residue |
| C | GLU97 |
| C | PRO98 |
| C | ILE124 |
| C | LEU126 |
| C | HOH2033 |
| C | HOH2039 |
| site_id | CC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K B 1567 |
| Chain | Residue |
| B | ILE163 |
| B | GLU193 |
| B | HOH2116 |
| B | HOH2117 |
| B | HOH2121 |
| B | HOH2153 |
Functional Information from PROSITE/UniProt
