5A40

Crystal structure of a dual topology fluoride ion channel.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0062054	molecular_function	fluoride channel activity
A	0140114	biological_process	cellular detoxification of fluoride
A	1903424	biological_process	fluoride transmembrane transport
A	1903425	molecular_function	fluoride transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0062054	molecular_function	fluoride channel activity
B	0140114	biological_process	cellular detoxification of fluoride
B	1903424	biological_process	fluoride transmembrane transport
B	1903425	molecular_function	fluoride transmembrane transporter activity
C	0005886	cellular_component	plasma membrane
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0062054	molecular_function	fluoride channel activity
C	0140114	biological_process	cellular detoxification of fluoride
C	1903424	biological_process	fluoride transmembrane transport
C	1903425	molecular_function	fluoride transmembrane transporter activity
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0062054	molecular_function	fluoride channel activity
D	0140114	biological_process	cellular detoxification of fluoride
D	1903424	biological_process	fluoride transmembrane transport
D	1903425	molecular_function	fluoride transmembrane transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG F 1092

Chain	Residue
B	ASP91
B	CYS94
F	TYR75

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG E 1092

Chain	Residue
A	ASP91
A	CYS94
E	HIS81

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG G 1092

Chain	Residue
C	ASP91
C	CYS94
G	HIS81

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG H 1092

Chain	Residue
D	ASP91
D	CYS94
H	HIS81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	TRANSMEM: Helical => ECO:0000269|PubMed:26344196, ECO:0007744|PDB:5A40, ECO:0007744|PDB:5NKQ

Chain	Residue	Details
A	LEU7-LYS29
C	PRO36-ILE57
C	ALA65-CYS94
C	TYR98-LEU126
D	LEU7-LYS29
D	PRO36-ILE57
D	ALA65-CYS94
D	TYR98-LEU126
A	PRO36-ILE57
A	ALA65-CYS94
A	TYR98-LEU126
B	LEU7-LYS29
B	PRO36-ILE57
B	ALA65-CYS94
B	TYR98-LEU126
C	LEU7-LYS29

---

site_id	SWS_FT_FI2
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269|PubMed:26344196, ECO:0007744|PDB:5NKQ

Chain	Residue	Details
A	ASN43
C	TYR104
C	SER108
C	SER112
D	ASN43
D	TYR104
D	SER108
D	SER112
A	TYR104
A	SER108
A	SER112
B	ASN43
B	TYR104
B	SER108
B	SER112
C	ASN43

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00454, ECO:0000269|PubMed:26344196, ECO:0007744|PDB:5NKQ

Chain	Residue	Details
A	GLY77
A	THR80
B	GLY77
B	THR80
C	GLY77
C	THR80
D	GLY77
D	THR80

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