5A40

Crystal structure of a dual topology fluoride ion channel.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0062054	molecular_function	fluoride channel activity
A	0140114	biological_process	cellular detoxification of fluoride
A	1903424	biological_process	fluoride transmembrane transport
A	1903425	molecular_function	fluoride transmembrane transporter activity
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0062054	molecular_function	fluoride channel activity
B	0140114	biological_process	cellular detoxification of fluoride
B	1903424	biological_process	fluoride transmembrane transport
B	1903425	molecular_function	fluoride transmembrane transporter activity
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0062054	molecular_function	fluoride channel activity
C	0140114	biological_process	cellular detoxification of fluoride
C	1903424	biological_process	fluoride transmembrane transport
C	1903425	molecular_function	fluoride transmembrane transporter activity
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0062054	molecular_function	fluoride channel activity
D	0140114	biological_process	cellular detoxification of fluoride
D	1903424	biological_process	fluoride transmembrane transport
D	1903425	molecular_function	fluoride transmembrane transporter activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG F 1092

Chain	Residue
B	ASP91
B	CYS94
F	TYR75

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG E 1092

Chain	Residue
A	ASP91
A	CYS94
E	HIS81

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site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG G 1092

Chain	Residue
C	ASP91
C	CYS94
G	HIS81

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site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE HG H 1092

Chain	Residue
D	ASP91
D	CYS94
H	HIS81

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"26344196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5A40","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5NKQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	16
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26344196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NKQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00454","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"26344196","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5NKQ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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