Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5A1X

The structure of the COPI coat linkage III

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005794	cellular_component	Golgi apparatus
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006886	biological_process	intracellular protein transport
A	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
A	0006893	biological_process	Golgi to plasma membrane transport
A	0010636	biological_process	positive regulation of mitochondrial fusion
A	0015031	biological_process	protein transport
A	0016192	biological_process	vesicle-mediated transport
A	0016236	biological_process	macroautophagy
A	0016787	molecular_function	hydrolase activity
A	0019217	biological_process	regulation of fatty acid metabolic process
A	0044232	cellular_component	organelle membrane contact site
A	0048193	biological_process	Golgi vesicle transport
A	0090141	biological_process	positive regulation of mitochondrial fission
A	1903292	biological_process	protein localization to Golgi membrane
A	1903358	biological_process	regulation of Golgi organization
B	0000166	molecular_function	nucleotide binding
B	0003924	molecular_function	GTPase activity
B	0003925	molecular_function	G protein activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006886	biological_process	intracellular protein transport
B	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
B	0006893	biological_process	Golgi to plasma membrane transport
B	0010636	biological_process	positive regulation of mitochondrial fusion
B	0015031	biological_process	protein transport
B	0016192	biological_process	vesicle-mediated transport
B	0016236	biological_process	macroautophagy
B	0016787	molecular_function	hydrolase activity
B	0019217	biological_process	regulation of fatty acid metabolic process
B	0044232	cellular_component	organelle membrane contact site
B	0048193	biological_process	Golgi vesicle transport
B	0090141	biological_process	positive regulation of mitochondrial fission
B	1903292	biological_process	protein localization to Golgi membrane
B	1903358	biological_process	regulation of Golgi organization
C	0000139	cellular_component	Golgi membrane
C	0003729	molecular_function	mRNA binding
C	0005179	molecular_function	hormone activity
C	0005198	molecular_function	structural molecule activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0005794	cellular_component	Golgi apparatus
C	0006886	biological_process	intracellular protein transport
C	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
C	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
C	0006891	biological_process	intra-Golgi vesicle-mediated transport
C	0007165	biological_process	signal transduction
C	0015031	biological_process	protein transport
C	0016192	biological_process	vesicle-mediated transport
C	0030117	cellular_component	membrane coat
C	0030126	cellular_component	COPI vesicle coat
C	0030137	cellular_component	COPI-coated vesicle
C	0030157	biological_process	pancreatic juice secretion
C	0030424	cellular_component	axon
C	0030426	cellular_component	growth cone
C	0030663	cellular_component	COPI-coated vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0044297	cellular_component	cell body
C	0099612	biological_process	protein localization to axon
C	1902463	biological_process	protein localization to cell leading edge
D	0000139	cellular_component	Golgi membrane
D	0005080	molecular_function	protein kinase C binding
D	0005198	molecular_function	structural molecule activity
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0006886	biological_process	intracellular protein transport
D	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
D	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
D	0006891	biological_process	intra-Golgi vesicle-mediated transport
D	0015031	biological_process	protein transport
D	0016192	biological_process	vesicle-mediated transport
D	0030117	cellular_component	membrane coat
D	0030126	cellular_component	COPI vesicle coat
D	0030663	cellular_component	COPI-coated vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
E	0000139	cellular_component	Golgi membrane
E	0005198	molecular_function	structural molecule activity
E	0005783	cellular_component	endoplasmic reticulum
E	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0006886	biological_process	intracellular protein transport
E	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
E	0006891	biological_process	intra-Golgi vesicle-mediated transport
E	0009306	biological_process	protein secretion
E	0015031	biological_process	protein transport
E	0016192	biological_process	vesicle-mediated transport
E	0030117	cellular_component	membrane coat
E	0030126	cellular_component	COPI vesicle coat
E	0030663	cellular_component	COPI-coated vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0051683	biological_process	establishment of Golgi localization
E	0072384	biological_process	organelle transport along microtubule
F	0000139	cellular_component	Golgi membrane
F	0003674	molecular_function	molecular_function
F	0005737	cellular_component	cytoplasm
F	0006886	biological_process	intracellular protein transport
F	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
F	0006891	biological_process	intra-Golgi vesicle-mediated transport
F	0015031	biological_process	protein transport
F	0016192	biological_process	vesicle-mediated transport
F	0030117	cellular_component	membrane coat
F	0030126	cellular_component	COPI vesicle coat
F	0030663	cellular_component	COPI-coated vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
G	0000139	cellular_component	Golgi membrane
G	0005198	molecular_function	structural molecule activity
G	0005737	cellular_component	cytoplasm
G	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
G	0005794	cellular_component	Golgi apparatus
G	0005798	cellular_component	Golgi-associated vesicle
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0006886	biological_process	intracellular protein transport
G	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
G	0006891	biological_process	intra-Golgi vesicle-mediated transport
G	0015031	biological_process	protein transport
G	0016192	biological_process	vesicle-mediated transport
G	0030117	cellular_component	membrane coat
G	0030126	cellular_component	COPI vesicle coat
G	0030137	cellular_component	COPI-coated vesicle
G	0030663	cellular_component	COPI-coated vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
H	0000139	cellular_component	Golgi membrane
H	0005737	cellular_component	cytoplasm
H	0005783	cellular_component	endoplasmic reticulum
H	0005794	cellular_component	Golgi apparatus
H	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
H	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
H	0008344	biological_process	adult locomotory behavior
H	0015031	biological_process	protein transport
H	0016192	biological_process	vesicle-mediated transport
H	0021691	biological_process	cerebellar Purkinje cell layer maturation
H	0030126	cellular_component	COPI vesicle coat
H	0030137	cellular_component	COPI-coated vesicle
H	0030663	cellular_component	COPI-coated vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0043473	biological_process	pigmentation
H	0048193	biological_process	Golgi vesicle transport
H	0051645	biological_process	Golgi localization
I	0000166	molecular_function	nucleotide binding
I	0003924	molecular_function	GTPase activity
I	0003925	molecular_function	G protein activity
I	0005515	molecular_function	protein binding
I	0005525	molecular_function	GTP binding
I	0005737	cellular_component	cytoplasm
I	0005794	cellular_component	Golgi apparatus
I	0005829	cellular_component	cytosol
I	0005886	cellular_component	plasma membrane
I	0006886	biological_process	intracellular protein transport
I	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
I	0006893	biological_process	Golgi to plasma membrane transport
I	0010636	biological_process	positive regulation of mitochondrial fusion
I	0015031	biological_process	protein transport
I	0016192	biological_process	vesicle-mediated transport
I	0016236	biological_process	macroautophagy
I	0016787	molecular_function	hydrolase activity
I	0019217	biological_process	regulation of fatty acid metabolic process
I	0044232	cellular_component	organelle membrane contact site
I	0048193	biological_process	Golgi vesicle transport
I	0090141	biological_process	positive regulation of mitochondrial fission
I	1903292	biological_process	protein localization to Golgi membrane
I	1903358	biological_process	regulation of Golgi organization
J	0000166	molecular_function	nucleotide binding
J	0003924	molecular_function	GTPase activity
J	0003925	molecular_function	G protein activity
J	0005515	molecular_function	protein binding
J	0005525	molecular_function	GTP binding
J	0005737	cellular_component	cytoplasm
J	0005794	cellular_component	Golgi apparatus
J	0005829	cellular_component	cytosol
J	0005886	cellular_component	plasma membrane
J	0006886	biological_process	intracellular protein transport
J	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
J	0006893	biological_process	Golgi to plasma membrane transport
J	0010636	biological_process	positive regulation of mitochondrial fusion
J	0015031	biological_process	protein transport
J	0016192	biological_process	vesicle-mediated transport
J	0016236	biological_process	macroautophagy
J	0016787	molecular_function	hydrolase activity
J	0019217	biological_process	regulation of fatty acid metabolic process
J	0044232	cellular_component	organelle membrane contact site
J	0048193	biological_process	Golgi vesicle transport
J	0090141	biological_process	positive regulation of mitochondrial fission
J	1903292	biological_process	protein localization to Golgi membrane
J	1903358	biological_process	regulation of Golgi organization
K	0000139	cellular_component	Golgi membrane
K	0003729	molecular_function	mRNA binding
K	0005179	molecular_function	hormone activity
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0005794	cellular_component	Golgi apparatus
K	0006886	biological_process	intracellular protein transport
K	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
K	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
K	0006891	biological_process	intra-Golgi vesicle-mediated transport
K	0007165	biological_process	signal transduction
K	0015031	biological_process	protein transport
K	0016192	biological_process	vesicle-mediated transport
K	0030117	cellular_component	membrane coat
K	0030126	cellular_component	COPI vesicle coat
K	0030137	cellular_component	COPI-coated vesicle
K	0030157	biological_process	pancreatic juice secretion
K	0030424	cellular_component	axon
K	0030426	cellular_component	growth cone
K	0030663	cellular_component	COPI-coated vesicle membrane
K	0031410	cellular_component	cytoplasmic vesicle
K	0044297	cellular_component	cell body
K	0099612	biological_process	protein localization to axon
K	1902463	biological_process	protein localization to cell leading edge
L	0000139	cellular_component	Golgi membrane
L	0005080	molecular_function	protein kinase C binding
L	0005198	molecular_function	structural molecule activity
L	0005794	cellular_component	Golgi apparatus
L	0005829	cellular_component	cytosol
L	0006886	biological_process	intracellular protein transport
L	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
L	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
L	0006891	biological_process	intra-Golgi vesicle-mediated transport
L	0015031	biological_process	protein transport
L	0016192	biological_process	vesicle-mediated transport
L	0030117	cellular_component	membrane coat
L	0030126	cellular_component	COPI vesicle coat
L	0030663	cellular_component	COPI-coated vesicle membrane
L	0031410	cellular_component	cytoplasmic vesicle
M	0000139	cellular_component	Golgi membrane
M	0005198	molecular_function	structural molecule activity
M	0005783	cellular_component	endoplasmic reticulum
M	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
M	0005794	cellular_component	Golgi apparatus
M	0005829	cellular_component	cytosol
M	0006886	biological_process	intracellular protein transport
M	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
M	0006891	biological_process	intra-Golgi vesicle-mediated transport
M	0009306	biological_process	protein secretion
M	0015031	biological_process	protein transport
M	0016192	biological_process	vesicle-mediated transport
M	0030117	cellular_component	membrane coat
M	0030126	cellular_component	COPI vesicle coat
M	0030663	cellular_component	COPI-coated vesicle membrane
M	0031410	cellular_component	cytoplasmic vesicle
M	0051683	biological_process	establishment of Golgi localization
M	0072384	biological_process	organelle transport along microtubule
N	0000139	cellular_component	Golgi membrane
N	0003674	molecular_function	molecular_function
N	0005737	cellular_component	cytoplasm
N	0006886	biological_process	intracellular protein transport
N	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
N	0006891	biological_process	intra-Golgi vesicle-mediated transport
N	0015031	biological_process	protein transport
N	0016192	biological_process	vesicle-mediated transport
N	0030117	cellular_component	membrane coat
N	0030126	cellular_component	COPI vesicle coat
N	0030663	cellular_component	COPI-coated vesicle membrane
N	0031410	cellular_component	cytoplasmic vesicle
O	0000139	cellular_component	Golgi membrane
O	0005198	molecular_function	structural molecule activity
O	0005737	cellular_component	cytoplasm
O	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
O	0005794	cellular_component	Golgi apparatus
O	0005798	cellular_component	Golgi-associated vesicle
O	0005829	cellular_component	cytosol
O	0005886	cellular_component	plasma membrane
O	0006886	biological_process	intracellular protein transport
O	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
O	0006891	biological_process	intra-Golgi vesicle-mediated transport
O	0015031	biological_process	protein transport
O	0016192	biological_process	vesicle-mediated transport
O	0030117	cellular_component	membrane coat
O	0030126	cellular_component	COPI vesicle coat
O	0030137	cellular_component	COPI-coated vesicle
O	0030663	cellular_component	COPI-coated vesicle membrane
O	0031410	cellular_component	cytoplasmic vesicle
P	0000139	cellular_component	Golgi membrane
P	0005737	cellular_component	cytoplasm
P	0005783	cellular_component	endoplasmic reticulum
P	0005794	cellular_component	Golgi apparatus
P	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
P	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
P	0008344	biological_process	adult locomotory behavior
P	0015031	biological_process	protein transport
P	0016192	biological_process	vesicle-mediated transport
P	0021691	biological_process	cerebellar Purkinje cell layer maturation
P	0030126	cellular_component	COPI vesicle coat
P	0030137	cellular_component	COPI-coated vesicle
P	0030663	cellular_component	COPI-coated vesicle membrane
P	0031410	cellular_component	cytoplasmic vesicle
P	0043473	biological_process	pigmentation
P	0048193	biological_process	Golgi vesicle transport
P	0051645	biological_process	Golgi localization
Q	0000139	cellular_component	Golgi membrane
Q	0005737	cellular_component	cytoplasm
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005794	cellular_component	Golgi apparatus
Q	0006888	biological_process	endoplasmic reticulum to Golgi vesicle-mediated transport
Q	0006890	biological_process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
Q	0008344	biological_process	adult locomotory behavior
Q	0015031	biological_process	protein transport
Q	0016192	biological_process	vesicle-mediated transport
Q	0021691	biological_process	cerebellar Purkinje cell layer maturation
Q	0030126	cellular_component	COPI vesicle coat
Q	0030137	cellular_component	COPI-coated vesicle
Q	0030663	cellular_component	COPI-coated vesicle membrane
Q	0031410	cellular_component	cytoplasmic vesicle
Q	0043473	biological_process	pigmentation
Q	0048193	biological_process	Golgi vesicle transport
Q	0051645	biological_process	Golgi localization

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. VVSAslDqTVRVWDI

Chain	Residue	Details
C	VAL150-ILE164

site_id	PS00989
Number of Residues	11
Details	CLAT_ADAPTOR_S Clathrin adaptor complexes small chain signature. VVYKssidLYF

Chain	Residue	Details
F	VAL67-PHE77

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	52
Details	Binding site: {"evidences":[{"source":"PubMed","id":"20601958","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	8
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"22106047","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	68
Details	Peptide: {"description":"Proxenin","featureId":"PRO_0000327497"}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	48
Details	Peptide: {"description":"Xenin","featureId":"PRO_0000327498"}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	138
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	138
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	138
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	140
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	142
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	138
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21183079","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P53621","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	76
Details	Repeat: {"description":"WD 7"}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	70
Details	Repeat: {"description":"WD 8"}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	74
Details	Repeat: {"description":"WD 9"}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	2
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P35606","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	144
Details	Repeat: {"description":"HEAT 1"}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	146
Details	Repeat: {"description":"HEAT 2"}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	138
Details	Repeat: {"description":"HEAT 3"}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	146
Details	Repeat: {"description":"HEAT 4"}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	265
Details	Region: {"description":"Interaction with ZNF289/ARFGAP2","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	74
Details	Repeat: {"description":"HEAT 5"}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	74
Details	Repeat: {"description":"HEAT 6"}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	5
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"23806337","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	720
Details	Domain: {"description":"MHD","evidences":[{"source":"PROSITE-ProRule","id":"PRU00404","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48444","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)