5A07
X-ray structure of the mannosyltransferase Ktr4p from S. cerevisiae in complex with GDP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000026 | molecular_function | alpha-1,2-mannosyltransferase activity |
| A | 0000030 | molecular_function | mannosyltransferase activity |
| A | 0000032 | biological_process | cell wall mannoprotein biosynthetic process |
| A | 0000324 | cellular_component | fungal-type vacuole |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0006486 | biological_process | protein glycosylation |
| A | 0006487 | biological_process | protein N-linked glycosylation |
| A | 0006493 | biological_process | protein O-linked glycosylation |
| A | 0016020 | cellular_component | membrane |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0097502 | biological_process | mannosylation |
| B | 0000026 | molecular_function | alpha-1,2-mannosyltransferase activity |
| B | 0000030 | molecular_function | mannosyltransferase activity |
| B | 0000032 | biological_process | cell wall mannoprotein biosynthetic process |
| B | 0000324 | cellular_component | fungal-type vacuole |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0006486 | biological_process | protein glycosylation |
| B | 0006487 | biological_process | protein N-linked glycosylation |
| B | 0006493 | biological_process | protein O-linked glycosylation |
| B | 0016020 | cellular_component | membrane |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0097502 | biological_process | mannosylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 500 |
| Chain | Residue |
| A | LEU140 |
| A | TYR235 |
| A | MET238 |
| A | GLU262 |
| A | PRO263 |
| A | HIS411 |
| A | MN501 |
| A | HOH2070 |
| A | HOH2071 |
| A | HOH2105 |
| A | HOH2158 |
| A | VAL141 |
| A | HOH2232 |
| A | HOH2258 |
| A | HOH2300 |
| A | ARG142 |
| A | ASP145 |
| A | ASN172 |
| A | ASP173 |
| A | TRP204 |
| A | TYR229 |
| A | SER234 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 501 |
| Chain | Residue |
| A | GLU262 |
| A | HIS411 |
| A | GDP500 |
| A | HOH2177 |
| A | HOH2258 |
| site_id | AC3 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE GDP B 500 |
| Chain | Residue |
| B | LEU140 |
| B | VAL141 |
| B | ARG142 |
| B | ASP145 |
| B | ASN172 |
| B | ASP173 |
| B | TYR229 |
| B | SER234 |
| B | TYR235 |
| B | MET238 |
| B | GLU262 |
| B | PRO263 |
| B | HIS411 |
| B | MN501 |
| B | HOH2074 |
| B | HOH2075 |
| B | HOH2105 |
| B | HOH2153 |
| B | HOH2219 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN B 501 |
| Chain | Residue |
| B | GLU262 |
| B | HIS411 |
| B | GDP500 |
| B | HOH2171 |
| B | HOH2243 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE ACT A 1465 |
| Chain | Residue |
| A | LEU83 |
| A | HIS84 |
| A | PRO86 |
| A | LYS327 |
| A | TYR336 |
| A | HOH2007 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ACT B 1465 |
| Chain | Residue |
| B | HIS84 |
| B | PRO86 |
| B | LYS327 |
| B | TYR336 |
| B | HOH2005 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 862 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN33-TYR464 | |
| B | ASN33-TYR464 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU352 | |
| B | GLU352 |
