4ZYF

Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with NVP-CGM097

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue 4T4 A 201

Chain	Residue
A	GLN24
A	TYR100
A	HOH302
A	HOH311
A	HOH323
A	HOH337
A	LEU54
A	PHE55
A	MET62
A	TYR67
A	GLN72
A	PHE86
A	ARG97
A	LYS98

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site_id	AC2
Number of Residues	6
Details	binding site for residue CL A 202

Chain	Residue
A	LYS64
A	LYS64
A	ASP80
A	ASP80
A	LEU81
A	LEU81

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