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4ZYF

Discovery of NVP-CGM097 - a highly potent and selective MDM2 inhibitor undergoing phase 1 clinical trials in p53wt tumors: Hdm2 (MDM2) complexed with NVP-CGM097

Functional Information from GO Data
ChainGOidnamespacecontents
A0005634cellular_componentnucleus
A0043066biological_processnegative regulation of apoptotic process
A0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues14
Detailsbinding site for residue 4T4 A 201
ChainResidue
AGLN24
ATYR100
AHOH302
AHOH311
AHOH323
AHOH337
ALEU54
APHE55
AMET62
ATYR67
AGLN72
APHE86
AARG97
ALYS98

site_idAC2
Number of Residues6
Detailsbinding site for residue CL A 202
ChainResidue
ALYS64
ALYS64
AASP80
AASP80
ALEU81
ALEU81

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues83
DetailsDomain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246031

PDB entries from 2025-12-10

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