4ZX4
X-ray crystal structure of PfA-M1 in complex with hydroxamic acid-based inhibitor 10o
Functional Information from GO Data
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 19 |
Details | binding site for residue 4TL A 1101 |
Chain | Residue |
A | THR305 |
A | ARG489 |
A | HIS496 |
A | GLU497 |
A | HIS500 |
A | GLU519 |
A | GLU572 |
A | TYR575 |
A | TYR580 |
A | MET1034 |
A | ZN1102 |
A | GLN317 |
A | GLU319 |
A | ALA320 |
A | ASN458 |
A | VAL459 |
A | GLY460 |
A | ALA461 |
A | GLU463 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue ZN A 1102 |
Chain | Residue |
A | HIS496 |
A | HIS500 |
A | GLU519 |
A | 4TL1101 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue MG A 1103 |
Chain | Residue |
A | HOH1331 |
A | HOH1423 |
A | HOH1502 |
A | HOH2012 |
A | HOH2122 |
site_id | AC4 |
Number of Residues | 3 |
Details | binding site for residue PO4 A 1104 |
Chain | Residue |
A | GLU699 |
A | ASN700 |
A | TYR757 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue GOL A 1105 |
Chain | Residue |
A | ASN573 |
A | THR576 |
A | THR1037 |
A | GLN1038 |
A | TYR1077 |
A | HOH1302 |
A | HOH1369 |
A | HOH1585 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue GOL A 1106 |
Chain | Residue |
A | HIS653 |
A | LYS676 |
A | TYR741 |
A | ASN835 |
A | PHE836 |
A | HOH1290 |
A | HOH1405 |
A | HOH1440 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue GOL A 1107 |
Chain | Residue |
A | TYR853 |
A | SER903 |
A | TYR938 |
A | DMS1110 |
A | HOH1713 |
A | HOH1796 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue DMS A 1108 |
Chain | Residue |
A | ASP758 |
A | SER759 |
A | ALA761 |
A | ARG764 |
A | HOH1803 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue DMS A 1109 |
Chain | Residue |
A | SER822 |
A | TYR823 |
A | SER826 |
A | THR900 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue DMS A 1110 |
Chain | Residue |
A | SER826 |
A | TYR853 |
A | SER903 |
A | GOL1107 |
Functional Information from PROSITE/UniProt
site_id | PS00142 |
Number of Residues | 10 |
Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VVGHEYFHQY |
Chain | Residue | Details |
A | VAL493-TYR502 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | GLU497 |
site_id | SWS_FT_FI2 |
Number of Residues | 3 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3EBI, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | GLU319 | |
A | GLY460 | |
A | GLU463 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | BINDING: BINDING => ECO:0000305|PubMed:19196988, ECO:0000305|PubMed:21366301, ECO:0007744|PDB:3EBH, ECO:0007744|PDB:3Q43 |
Chain | Residue | Details |
A | ALA461 |
Chain | Residue | Details |
A | HIS496 | |
A | HIS500 | |
A | GLU519 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | SITE: Important for substrate specificity => ECO:0000269|PubMed:23897806 |
Chain | Residue | Details |
A | VAL459 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Transition state stabilizer => ECO:0000250|UniProtKB:P15144 |
Chain | Residue | Details |
A | TYR580 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | SITE: Cleavage => ECO:0000305|PubMed:21659511 |
Chain | Residue | Details |
A | GLN795 |