4ZWM
2.3 A resolution crystal structure of the ornithine aminotransferase from Toxoplasma gondii ME49
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004587 | molecular_function | ornithine aminotransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008483 | molecular_function | transaminase activity |
| A | 0010121 | biological_process | arginine catabolic process to proline via ornithine |
| A | 0019544 | biological_process | arginine catabolic process to glutamate |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0055129 | biological_process | L-proline biosynthetic process |
| B | 0004587 | molecular_function | ornithine aminotransferase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0008483 | molecular_function | transaminase activity |
| B | 0010121 | biological_process | arginine catabolic process to proline via ornithine |
| B | 0019544 | biological_process | arginine catabolic process to glutamate |
| B | 0030170 | molecular_function | pyridoxal phosphate binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0055129 | biological_process | L-proline biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | binding site for residue PLP A 501 |
| Chain | Residue |
| A | GLY136 |
| A | HOH635 |
| A | HOH653 |
| B | THR316 |
| B | HOH626 |
| A | ALA137 |
| A | TYR171 |
| A | TRP172 |
| A | GLU224 |
| A | ASP257 |
| A | ILE259 |
| A | GLN260 |
| A | LYS286 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 502 |
| Chain | Residue |
| A | CYS264 |
| A | LYS335 |
| A | HOH603 |
| A | HOH642 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 503 |
| Chain | Residue |
| A | VAL234 |
| A | ARG355 |
| A | ILE368 |
| A | ARG369 |
| A | GLY370 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 504 |
| Chain | Residue |
| A | GLN349 |
| A | HIS421 |
| A | ARG422 |
| A | THR425 |
| site_id | AC5 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 505 |
| Chain | Residue |
| A | MET133 |
| A | GLU138 |
| A | GLU141 |
| A | SER142 |
| A | HIS313 |
| B | ARG174 |
| B | THR175 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 506 |
| Chain | Residue |
| A | LEU106 |
| A | ALA108 |
| B | TYR49 |
| B | GLU229 |
| B | ARG409 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 507 |
| Chain | Residue |
| A | TYR49 |
| A | LEU76 |
| A | GLU229 |
| A | LYS401 |
| B | ALA108 |
| site_id | AC8 |
| Number of Residues | 11 |
| Details | binding site for residue PLP B 501 |
| Chain | Residue |
| A | THR316 |
| B | GLY136 |
| B | ALA137 |
| B | TYR171 |
| B | TRP172 |
| B | GLU224 |
| B | ASP257 |
| B | ILE259 |
| B | GLN260 |
| B | LYS286 |
| B | HOH632 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 502 |
| Chain | Residue |
| A | ARG90 |
| A | ALA93 |
| A | ALA94 |
| A | ARG97 |
| A | GLU329 |
| B | THR20 |
| B | ASN21 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 503 |
| Chain | Residue |
| A | LEU29 |
| A | LEU31 |
| A | CYS40 |
| A | TYR44 |
| B | ARG119 |
| B | HOH602 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 504 |
| Chain | Residue |
| A | ARG174 |
| A | THR175 |
| B | MET133 |
| B | GLU138 |
| B | GLU141 |
| B | SER142 |
| B | HIS313 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 505 |
| Chain | Residue |
| B | VAL234 |
| B | ARG355 |
| B | ARG369 |
| B | GLY370 |
| B | HOH634 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 506 |
| Chain | Residue |
| B | LEU269 |
| B | LYS335 |
| B | HOH641 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 507 |
| Chain | Residue |
| A | ARG119 |
| B | LEU31 |
| B | CYS40 |
| B | TYR44 |
Functional Information from PROSITE/UniProt
| site_id | PS00600 |
| Number of Residues | 38 |
| Details | AA_TRANSFER_CLASS_3 Aminotransferases class-III pyridoxal-phosphate attachment site. LIvDEIqt.GLcRtGrllaadhdevhp....DILllGKslsAG |
| Chain | Residue | Details |
| A | LEU254-GLY291 |
