4ZTT
Crystal structures of ferritin mutants reveal diferric-peroxo intermediates
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004322 | molecular_function | ferroxidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0006974 | biological_process | DNA damage response |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0008198 | molecular_function | ferrous iron binding |
| A | 0008199 | molecular_function | ferric iron binding |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0071281 | biological_process | cellular response to iron ion |
| A | 0140315 | molecular_function | iron ion sequestering activity |
| B | 0004322 | molecular_function | ferroxidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006974 | biological_process | DNA damage response |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0008198 | molecular_function | ferrous iron binding |
| B | 0008199 | molecular_function | ferric iron binding |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0140315 | molecular_function | iron ion sequestering activity |
| C | 0004322 | molecular_function | ferroxidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0006974 | biological_process | DNA damage response |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0008198 | molecular_function | ferrous iron binding |
| C | 0008199 | molecular_function | ferric iron binding |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0071281 | biological_process | cellular response to iron ion |
| C | 0140315 | molecular_function | iron ion sequestering activity |
| D | 0004322 | molecular_function | ferroxidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0006826 | biological_process | iron ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0006974 | biological_process | DNA damage response |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0008198 | molecular_function | ferrous iron binding |
| D | 0008199 | molecular_function | ferric iron binding |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0071281 | biological_process | cellular response to iron ion |
| D | 0140315 | molecular_function | iron ion sequestering activity |
| E | 0004322 | molecular_function | ferroxidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0006826 | biological_process | iron ion transport |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0006974 | biological_process | DNA damage response |
| E | 0006979 | biological_process | response to oxidative stress |
| E | 0008198 | molecular_function | ferrous iron binding |
| E | 0008199 | molecular_function | ferric iron binding |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0071281 | biological_process | cellular response to iron ion |
| E | 0140315 | molecular_function | iron ion sequestering activity |
| F | 0004322 | molecular_function | ferroxidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0006826 | biological_process | iron ion transport |
| F | 0006879 | biological_process | intracellular iron ion homeostasis |
| F | 0006974 | biological_process | DNA damage response |
| F | 0006979 | biological_process | response to oxidative stress |
| F | 0008198 | molecular_function | ferrous iron binding |
| F | 0008199 | molecular_function | ferric iron binding |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0071281 | biological_process | cellular response to iron ion |
| F | 0140315 | molecular_function | iron ion sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue FEO A 201 |
| Chain | Residue |
| A | GLU17 |
| A | GLU50 |
| A | HIS53 |
| A | GLU94 |
| A | GLN127 |
| A | GLU130 |
| A | OH202 |
| A | OH203 |
| A | HOH301 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue OH A 202 |
| Chain | Residue |
| A | GLU17 |
| A | HIS53 |
| A | TYR123 |
| A | GLN127 |
| A | FEO201 |
| A | OH203 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue OH A 203 |
| Chain | Residue |
| A | GLU17 |
| A | GLU50 |
| A | ILE97 |
| A | FEO201 |
| A | OH202 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 204 |
| Chain | Residue |
| A | ASN15 |
| A | TYR19 |
| A | VAL73 |
| A | GLU74 |
| A | HOH305 |
| A | HOH309 |
| A | HOH339 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue GOL A 205 |
| Chain | Residue |
| A | GLN99 |
| A | ASN102 |
| A | HIS106 |
| A | HOH303 |
| C | GLN112 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue FEO B 201 |
| Chain | Residue |
| B | GLU17 |
| B | GLU50 |
| B | HIS53 |
| B | GLU94 |
| B | GLN127 |
| B | GLU130 |
| B | OH202 |
| B | OH203 |
| B | HOH301 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue OH B 202 |
| Chain | Residue |
| B | GLU17 |
| B | HIS53 |
| B | TYR123 |
| B | GLN127 |
| B | FEO201 |
| B | OH203 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue OH B 203 |
| Chain | Residue |
| B | GLU17 |
| B | GLU50 |
| B | ILE97 |
| B | FEO201 |
| B | OH202 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue GOL B 204 |
| Chain | Residue |
| B | SER21 |
| B | LEU22 |
| B | GLN25 |
| B | ALA47 |
| B | GLN48 |
| B | HOH327 |
| B | HOH354 |
| E | MET54 |
| E | GLN55 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue GOL B 205 |
| Chain | Residue |
| B | LEU2 |
| B | ASP113 |
| B | PRO115 |
| B | HOH392 |
| B | HOH412 |
| E | THR98 |
| E | ASN102 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue FE C 201 |
| Chain | Residue |
| C | GLU17 |
| C | GLU50 |
| C | HIS53 |
| C | FE2202 |
| C | OXY203 |
| C | OH204 |
| C | HOH301 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue FE2 C 202 |
| Chain | Residue |
| C | GLU50 |
| C | GLU94 |
| C | GLU130 |
| C | FE201 |
| C | OXY203 |
| C | HOH301 |
| site_id | AD4 |
| Number of Residues | 11 |
| Details | binding site for residue OXY C 203 |
| Chain | Residue |
| C | GLU17 |
| C | GLU50 |
| C | HIS53 |
| C | GLU94 |
| C | ILE97 |
| C | GLN127 |
| C | GLU130 |
| C | FE201 |
| C | FE2202 |
| C | OH204 |
| C | HOH301 |
| site_id | AD5 |
| Number of Residues | 6 |
| Details | binding site for residue OH C 204 |
| Chain | Residue |
| C | GLU17 |
| C | HIS53 |
| C | TYR123 |
| C | GLN127 |
| C | FE201 |
| C | OXY203 |
| site_id | AD6 |
| Number of Residues | 10 |
| Details | binding site for residue GOL C 205 |
| Chain | Residue |
| C | LEU22 |
| C | GLN25 |
| C | ALA47 |
| C | GLN48 |
| C | MET51 |
| C | HOH323 |
| D | MET51 |
| D | MET54 |
| D | GLN55 |
| C | SER21 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 206 |
| Chain | Residue |
| C | ILE7 |
| C | GLU8 |
| C | ASN11 |
| C | LEU67 |
| site_id | AD8 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 207 |
| Chain | Residue |
| B | SER136 |
| B | ASP139 |
| B | LYS140 |
| B | HOH314 |
| C | THR35 |
| C | HOH306 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL C 208 |
| Chain | Residue |
| C | ALA41 |
| C | ARG44 |
| C | ARG45 |
| C | HOH304 |
| C | HOH318 |
| C | HOH328 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue GOL C 209 |
| Chain | Residue |
| C | ARG69 |
| C | ASN71 |
| C | THR72 |
| C | HOH376 |
| D | HOH371 |
| site_id | AE2 |
| Number of Residues | 7 |
| Details | binding site for residue FE D 201 |
| Chain | Residue |
| D | GLU17 |
| D | GLU50 |
| D | HIS53 |
| D | FE202 |
| D | PER203 |
| D | OH204 |
| D | HOH301 |
| site_id | AE3 |
| Number of Residues | 5 |
| Details | binding site for residue FE D 202 |
| Chain | Residue |
| D | GLU50 |
| D | GLU94 |
| D | GLU130 |
| D | FE201 |
| D | PER203 |
| site_id | AE4 |
| Number of Residues | 11 |
| Details | binding site for residue PER D 203 |
| Chain | Residue |
| D | GLU17 |
| D | GLU50 |
| D | HIS53 |
| D | GLU94 |
| D | ILE97 |
| D | GLN127 |
| D | GLU130 |
| D | FE201 |
| D | FE202 |
| D | OH204 |
| D | HOH301 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue OH D 204 |
| Chain | Residue |
| D | GLU17 |
| D | HIS53 |
| D | TYR123 |
| D | GLN127 |
| D | FE201 |
| D | PER203 |
| D | HOH301 |
| site_id | AE6 |
| Number of Residues | 4 |
| Details | binding site for residue GOL D 205 |
| Chain | Residue |
| D | GLN99 |
| D | HIS106 |
| D | HOH375 |
| E | GLN112 |
| site_id | AE7 |
| Number of Residues | 5 |
| Details | binding site for residue GOL D 206 |
| Chain | Residue |
| A | LYS146 |
| A | HOH308 |
| D | GLY148 |
| D | GLU149 |
| D | HOH362 |
| site_id | AE8 |
| Number of Residues | 9 |
| Details | binding site for residue FEO E 201 |
| Chain | Residue |
| E | GLU17 |
| E | GLU50 |
| E | HIS53 |
| E | GLU94 |
| E | GLN127 |
| E | GLU130 |
| E | OH202 |
| E | HOH301 |
| E | HOH303 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue OH E 202 |
| Chain | Residue |
| E | GLU17 |
| E | HIS53 |
| E | TYR123 |
| E | GLN127 |
| E | FEO201 |
| E | HOH301 |
| site_id | AF1 |
| Number of Residues | 8 |
| Details | binding site for residue GOL E 203 |
| Chain | Residue |
| E | ILE7 |
| E | GLU8 |
| E | ASN11 |
| E | LEU67 |
| E | ARG69 |
| E | HOH306 |
| E | HOH309 |
| E | HOH369 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue GOL E 204 |
| Chain | Residue |
| A | GLN112 |
| B | SER75 |
| E | ARG69 |
| E | ASN71 |
| E | THR72 |
| site_id | AF3 |
| Number of Residues | 4 |
| Details | binding site for residue FE2 E 205 |
| Chain | Residue |
| E | GLU149 |
| E | GLU149 |
| E | GLU149 |
| E | GLU149 |
| site_id | AF4 |
| Number of Residues | 6 |
| Details | binding site for residue FE F 201 |
| Chain | Residue |
| F | GLU50 |
| F | GLU94 |
| F | GLU130 |
| F | FE202 |
| F | O203 |
| F | HOH301 |
| site_id | AF5 |
| Number of Residues | 7 |
| Details | binding site for residue FE F 202 |
| Chain | Residue |
| F | GLU17 |
| F | GLU50 |
| F | HIS53 |
| F | FE201 |
| F | O203 |
| F | OH204 |
| F | OH205 |
| site_id | AF6 |
| Number of Residues | 10 |
| Details | binding site for residue O F 203 |
| Chain | Residue |
| F | GLU17 |
| F | GLU50 |
| F | HIS53 |
| F | GLU94 |
| F | GLU130 |
| F | FE201 |
| F | FE202 |
| F | OH204 |
| F | OH205 |
| F | HOH301 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue OH F 204 |
| Chain | Residue |
| F | GLU17 |
| F | HIS53 |
| F | TYR123 |
| F | FE202 |
| F | O203 |
| F | OH205 |
| site_id | AF8 |
| Number of Residues | 7 |
| Details | binding site for residue OH F 205 |
| Chain | Residue |
| F | GLU17 |
| F | ALA20 |
| F | GLU50 |
| F | ILE97 |
| F | FE202 |
| F | O203 |
| F | OH204 |
| site_id | AF9 |
| Number of Residues | 8 |
| Details | binding site for residue GOL F 206 |
| Chain | Residue |
| A | MET54 |
| A | GLN55 |
| F | SER21 |
| F | LEU22 |
| F | GLN25 |
| F | ALA47 |
| F | GLN48 |
| F | HOH346 |
| site_id | AG1 |
| Number of Residues | 15 |
| Details |
| Chain | Residue |
| F | GLU94 |
| F | ILE97 |
| F | THR98 |
| F | TYR123 |
| F | VAL124 |
| F | SER125 |
| F | GLU126 |
| F | HIS128 |
| F | GLU129 |
| F | GLU130 |
| F | GLU131 |
| F | FE201 |
| F | FE202 |
| F | O203 |
| F | OH204 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 48 |
| Details | Binding site: {} |
| Chain | Residue | Details |
