4ZTT
Crystal structures of ferritin mutants reveal diferric-peroxo intermediates
This is a non-PDB format compatible entry.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004322 | molecular_function | ferroxidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0006826 | biological_process | iron ion transport |
A | 0006879 | biological_process | intracellular iron ion homeostasis |
A | 0006974 | biological_process | DNA damage response |
A | 0006979 | biological_process | response to oxidative stress |
A | 0008198 | molecular_function | ferrous iron binding |
A | 0008199 | molecular_function | ferric iron binding |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0071281 | biological_process | cellular response to iron ion |
A | 0140315 | molecular_function | iron ion sequestering activity |
B | 0004322 | molecular_function | ferroxidase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0006826 | biological_process | iron ion transport |
B | 0006879 | biological_process | intracellular iron ion homeostasis |
B | 0006974 | biological_process | DNA damage response |
B | 0006979 | biological_process | response to oxidative stress |
B | 0008198 | molecular_function | ferrous iron binding |
B | 0008199 | molecular_function | ferric iron binding |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0071281 | biological_process | cellular response to iron ion |
B | 0140315 | molecular_function | iron ion sequestering activity |
C | 0004322 | molecular_function | ferroxidase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0006826 | biological_process | iron ion transport |
C | 0006879 | biological_process | intracellular iron ion homeostasis |
C | 0006974 | biological_process | DNA damage response |
C | 0006979 | biological_process | response to oxidative stress |
C | 0008198 | molecular_function | ferrous iron binding |
C | 0008199 | molecular_function | ferric iron binding |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0042802 | molecular_function | identical protein binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0071281 | biological_process | cellular response to iron ion |
C | 0140315 | molecular_function | iron ion sequestering activity |
D | 0004322 | molecular_function | ferroxidase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0006826 | biological_process | iron ion transport |
D | 0006879 | biological_process | intracellular iron ion homeostasis |
D | 0006974 | biological_process | DNA damage response |
D | 0006979 | biological_process | response to oxidative stress |
D | 0008198 | molecular_function | ferrous iron binding |
D | 0008199 | molecular_function | ferric iron binding |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0042802 | molecular_function | identical protein binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0071281 | biological_process | cellular response to iron ion |
D | 0140315 | molecular_function | iron ion sequestering activity |
E | 0004322 | molecular_function | ferroxidase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0005829 | cellular_component | cytosol |
E | 0006826 | biological_process | iron ion transport |
E | 0006879 | biological_process | intracellular iron ion homeostasis |
E | 0006974 | biological_process | DNA damage response |
E | 0006979 | biological_process | response to oxidative stress |
E | 0008198 | molecular_function | ferrous iron binding |
E | 0008199 | molecular_function | ferric iron binding |
E | 0016491 | molecular_function | oxidoreductase activity |
E | 0042802 | molecular_function | identical protein binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0071281 | biological_process | cellular response to iron ion |
E | 0140315 | molecular_function | iron ion sequestering activity |
F | 0004322 | molecular_function | ferroxidase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0006826 | biological_process | iron ion transport |
F | 0006879 | biological_process | intracellular iron ion homeostasis |
F | 0006974 | biological_process | DNA damage response |
F | 0006979 | biological_process | response to oxidative stress |
F | 0008198 | molecular_function | ferrous iron binding |
F | 0008199 | molecular_function | ferric iron binding |
F | 0016491 | molecular_function | oxidoreductase activity |
F | 0042802 | molecular_function | identical protein binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0071281 | biological_process | cellular response to iron ion |
F | 0140315 | molecular_function | iron ion sequestering activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | binding site for residue FEO A 201 |
Chain | Residue |
A | GLU17 |
A | GLU50 |
A | HIS53 |
A | GLU94 |
A | GLN127 |
A | GLU130 |
A | OH202 |
A | OH203 |
A | HOH301 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue OH A 202 |
Chain | Residue |
A | GLU17 |
A | HIS53 |
A | TYR123 |
A | GLN127 |
A | FEO201 |
A | OH203 |
site_id | AC3 |
Number of Residues | 5 |
Details | binding site for residue OH A 203 |
Chain | Residue |
A | GLU17 |
A | GLU50 |
A | ILE97 |
A | FEO201 |
A | OH202 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue GOL A 204 |
Chain | Residue |
A | ASN15 |
A | TYR19 |
A | VAL73 |
A | GLU74 |
A | HOH305 |
A | HOH309 |
A | HOH339 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue GOL A 205 |
Chain | Residue |
A | GLN99 |
A | ASN102 |
A | HIS106 |
A | HOH303 |
C | GLN112 |
site_id | AC6 |
Number of Residues | 9 |
Details | binding site for residue FEO B 201 |
Chain | Residue |
B | GLU17 |
B | GLU50 |
B | HIS53 |
B | GLU94 |
B | GLN127 |
B | GLU130 |
B | OH202 |
B | OH203 |
B | HOH301 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue OH B 202 |
Chain | Residue |
B | GLU17 |
B | HIS53 |
B | TYR123 |
B | GLN127 |
B | FEO201 |
B | OH203 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue OH B 203 |
Chain | Residue |
B | GLU17 |
B | GLU50 |
B | ILE97 |
B | FEO201 |
B | OH202 |
site_id | AC9 |
Number of Residues | 9 |
Details | binding site for residue GOL B 204 |
Chain | Residue |
B | SER21 |
B | LEU22 |
B | GLN25 |
B | ALA47 |
B | GLN48 |
B | HOH327 |
B | HOH354 |
E | MET54 |
E | GLN55 |
site_id | AD1 |
Number of Residues | 7 |
Details | binding site for residue GOL B 205 |
Chain | Residue |
B | LEU2 |
B | ASP113 |
B | PRO115 |
B | HOH392 |
B | HOH412 |
E | THR98 |
E | ASN102 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue FE C 201 |
Chain | Residue |
C | GLU17 |
C | GLU50 |
C | HIS53 |
C | FE2202 |
C | OXY203 |
C | OH204 |
C | HOH301 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue FE2 C 202 |
Chain | Residue |
C | GLU50 |
C | GLU94 |
C | GLU130 |
C | FE201 |
C | OXY203 |
C | HOH301 |
site_id | AD4 |
Number of Residues | 11 |
Details | binding site for residue OXY C 203 |
Chain | Residue |
C | GLU17 |
C | GLU50 |
C | HIS53 |
C | GLU94 |
C | ILE97 |
C | GLN127 |
C | GLU130 |
C | FE201 |
C | FE2202 |
C | OH204 |
C | HOH301 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue OH C 204 |
Chain | Residue |
C | GLU17 |
C | HIS53 |
C | TYR123 |
C | GLN127 |
C | FE201 |
C | OXY203 |
site_id | AD6 |
Number of Residues | 10 |
Details | binding site for residue GOL C 205 |
Chain | Residue |
C | LEU22 |
C | GLN25 |
C | ALA47 |
C | GLN48 |
C | MET51 |
C | HOH323 |
D | MET51 |
D | MET54 |
D | GLN55 |
C | SER21 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue GOL C 206 |
Chain | Residue |
C | ILE7 |
C | GLU8 |
C | ASN11 |
C | LEU67 |
site_id | AD8 |
Number of Residues | 6 |
Details | binding site for residue GOL C 207 |
Chain | Residue |
B | SER136 |
B | ASP139 |
B | LYS140 |
B | HOH314 |
C | THR35 |
C | HOH306 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue GOL C 208 |
Chain | Residue |
C | ALA41 |
C | ARG44 |
C | ARG45 |
C | HOH304 |
C | HOH318 |
C | HOH328 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue GOL C 209 |
Chain | Residue |
C | ARG69 |
C | ASN71 |
C | THR72 |
C | HOH376 |
D | HOH371 |
site_id | AE2 |
Number of Residues | 7 |
Details | binding site for residue FE D 201 |
Chain | Residue |
D | GLU17 |
D | GLU50 |
D | HIS53 |
D | FE202 |
D | PER203 |
D | OH204 |
D | HOH301 |
site_id | AE3 |
Number of Residues | 5 |
Details | binding site for residue FE D 202 |
Chain | Residue |
D | GLU50 |
D | GLU94 |
D | GLU130 |
D | FE201 |
D | PER203 |
site_id | AE4 |
Number of Residues | 11 |
Details | binding site for residue PER D 203 |
Chain | Residue |
D | GLU17 |
D | GLU50 |
D | HIS53 |
D | GLU94 |
D | ILE97 |
D | GLN127 |
D | GLU130 |
D | FE201 |
D | FE202 |
D | OH204 |
D | HOH301 |
site_id | AE5 |
Number of Residues | 7 |
Details | binding site for residue OH D 204 |
Chain | Residue |
D | GLU17 |
D | HIS53 |
D | TYR123 |
D | GLN127 |
D | FE201 |
D | PER203 |
D | HOH301 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue GOL D 205 |
Chain | Residue |
D | GLN99 |
D | HIS106 |
D | HOH375 |
E | GLN112 |
site_id | AE7 |
Number of Residues | 5 |
Details | binding site for residue GOL D 206 |
Chain | Residue |
A | LYS146 |
A | HOH308 |
D | GLY148 |
D | GLU149 |
D | HOH362 |
site_id | AE8 |
Number of Residues | 9 |
Details | binding site for residue FEO E 201 |
Chain | Residue |
E | GLU17 |
E | GLU50 |
E | HIS53 |
E | GLU94 |
E | GLN127 |
E | GLU130 |
E | OH202 |
E | HOH301 |
E | HOH303 |
site_id | AE9 |
Number of Residues | 6 |
Details | binding site for residue OH E 202 |
Chain | Residue |
E | GLU17 |
E | HIS53 |
E | TYR123 |
E | GLN127 |
E | FEO201 |
E | HOH301 |
site_id | AF1 |
Number of Residues | 8 |
Details | binding site for residue GOL E 203 |
Chain | Residue |
E | ILE7 |
E | GLU8 |
E | ASN11 |
E | LEU67 |
E | ARG69 |
E | HOH306 |
E | HOH309 |
E | HOH369 |
site_id | AF2 |
Number of Residues | 5 |
Details | binding site for residue GOL E 204 |
Chain | Residue |
A | GLN112 |
B | SER75 |
E | ARG69 |
E | ASN71 |
E | THR72 |
site_id | AF3 |
Number of Residues | 4 |
Details | binding site for residue FE2 E 205 |
Chain | Residue |
E | GLU149 |
E | GLU149 |
E | GLU149 |
E | GLU149 |
site_id | AF4 |
Number of Residues | 6 |
Details | binding site for residue FE F 201 |
Chain | Residue |
F | GLU50 |
F | GLU94 |
F | GLU130 |
F | FE202 |
F | O203 |
F | HOH301 |
site_id | AF5 |
Number of Residues | 7 |
Details | binding site for residue FE F 202 |
Chain | Residue |
F | GLU17 |
F | GLU50 |
F | HIS53 |
F | FE201 |
F | O203 |
F | OH204 |
F | OH205 |
site_id | AF6 |
Number of Residues | 10 |
Details | binding site for residue O F 203 |
Chain | Residue |
F | GLU17 |
F | GLU50 |
F | HIS53 |
F | GLU94 |
F | GLU130 |
F | FE201 |
F | FE202 |
F | OH204 |
F | OH205 |
F | HOH301 |
site_id | AF7 |
Number of Residues | 6 |
Details | binding site for residue OH F 204 |
Chain | Residue |
F | GLU17 |
F | HIS53 |
F | TYR123 |
F | FE202 |
F | O203 |
F | OH205 |
site_id | AF8 |
Number of Residues | 7 |
Details | binding site for residue OH F 205 |
Chain | Residue |
F | GLU17 |
F | ALA20 |
F | GLU50 |
F | ILE97 |
F | FE202 |
F | O203 |
F | OH204 |
site_id | AF9 |
Number of Residues | 8 |
Details | binding site for residue GOL F 206 |
Chain | Residue |
A | MET54 |
A | GLN55 |
F | SER21 |
F | LEU22 |
F | GLN25 |
F | ALA47 |
F | GLN48 |
F | HOH346 |
site_id | AG1 |
Number of Residues | 15 |
Details |
Chain | Residue |
F | GLU94 |
F | ILE97 |
F | THR98 |
F | TYR123 |
F | VAL124 |
F | SER125 |
F | GLU126 |
F | HIS128 |
F | GLU129 |
F | GLU130 |
F | GLU131 |
F | FE201 |
F | FE202 |
F | O203 |
F | OH204 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 48 |
Details | Binding site: {} |
Chain | Residue | Details |