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4ZP2

Crystal structure of E. coli multidrug transporter MdfA in complex with n-dodecyl-N,N-dimethylamine-N-oxide

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0015385molecular_functionsodium:proton antiporter activity
A0015386molecular_functionpotassium:proton antiporter activity
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0030641biological_processregulation of cellular pH
A0035725biological_processsodium ion transmembrane transport
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
A0071805biological_processpotassium ion transmembrane transport
A1902600biological_processproton transmembrane transport
A1990961biological_processxenobiotic detoxification by transmembrane export across the plasma membrane
Functional Information from PDB Data
site_idAC1
Number of Residues3
Detailsbinding site for residue LDA A 500
ChainResidue
AASN33
AASP34
AMET58

site_idAC2
Number of Residues5
Detailsbinding site for residue LDA A 501
ChainResidue
AALA163
AHIS166
AASP211
ASER253
ALEU259

Functional Information from PROSITE/UniProt
site_idPS00216
Number of Residues17
DetailsSUGAR_TRANSPORT_1 Sugar transport proteins signature 1. LGPLSDRIGRRpvmla.G
ChainResidueDetails
ALEU72-GLY88

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues235
DetailsTRANSMEM: Helical => ECO:0000305
ChainResidueDetails
AALA15-GLY32
ATRP315-VAL335
AGLY347-ILE367
ALEU379-LEU399
AVAL54-LEU72
APRO83-GLN103
ALEU110-ILE130
ALEU145-ILE165
AVAL167-GLY187
AALA227-ILE247
AGLU256-ALA276
AILE288-ILE308

site_idSWS_FT_FI2
Number of Residues48
DetailsTOPO_DOM: Periplasmic => ECO:0000305
ChainResidueDetails
AASN33-TRP53
AASN104-THR109
AHIS166
ATHR248-TYR255
ASER309-LEU314
ASER368-GLY378

site_idSWS_FT_FI3
Number of Residues80
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
AGLY73-ARG82
AARG131-ALA144
ALEU188-LEU226
AARG277-LEU287
AARG336-LYS346

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PDB entries from 2024-11-13

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