4ZND

2.55 Angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase (AroA) from Coxiella burnetii in complex with shikimate-3-phosphate, phosphate, and potassium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0003866	molecular_function	3-phosphoshikimate 1-carboxyvinyltransferase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016765	molecular_function	transferase activity, transferring alkyl or aryl (other than methyl) groups

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue S3P A 501

Chain	Residue
A	SER22
A	PO4502
A	HOH603
A	HOH610
A	HOH625
A	ARG26
A	THR96
A	SER167
A	ALA168
A	GLN169
A	ARG194
A	ASP315
A	LYS342

---

site_id	AC2
Number of Residues	11
Details	binding site for residue PO4 A 502

Chain	Residue
A	LYS21
A	ASN93
A	SER94
A	GLY95
A	THR96
A	ARG123
A	GLN169
A	GLU343
A	S3P501
A	K504
A	HOH605

---

site_id	AC3
Number of Residues	3
Details	binding site for residue PO4 A 503

Chain	Residue
A	PRO124
A	LYS126
A	ARG127

---

site_id	AC4
Number of Residues	5
Details	binding site for residue K A 504

Chain	Residue
A	ASP48
A	ASN93
A	GLU343
A	PO4502
A	HOH631

---

site_id	AC5
Number of Residues	3
Details	binding site for residue BME A 505

Chain	Residue
A	GLU14
A	CYS255
A	ASP292

---

Functional Information from PROSITE/UniProt

site_id	PS00104
Number of Residues	15
Details	EPSP_SYNTHASE_1 EPSP synthase signature 1. LDcGNSGTAIRlLsG

Chain	Residue	Details
A	LEU89-GLY103

---

site_id	PS00885
Number of Residues	19
Details	EPSP_SYNTHASE_2 EPSP synthase signature 2. RvKETDRIaAMvdgLqkLG

Chain	Residue	Details
A	ARG340-GLY358

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Region: {"description":"Phosphoenolpyruvate","evidences":[{"source":"HAMAP-Rule","id":"MF_00210","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"1.70 Angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase(AroA) from Coxiella burnetii in complex with shikimate-3-phosphate and glyphosate.","authoringGroup":["Center for Structural Genomics of Infectious Diseases (CSGID)"],"authors":["Light S.H.","Minasov G.","Filippova E.V.","Krishna S.N.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2012","submissionDatabase":"PDB data bank","title":"2.50 angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase (AroA) from Coxiella burnetii in complex with phosphoenolpyruvate.","authors":["Krishna S.N.","Light S.H.","Minasov G.","Shuvalova L.","Kwon K.","Anderson W.F."]}}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_00210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAR-2012","submissionDatabase":"PDB data bank","title":"2.50 angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase (AroA) from Coxiella burnetii in complex with phosphoenolpyruvate.","authors":["Krishna S.N.","Light S.H.","Minasov G.","Shuvalova L.","Kwon K.","Anderson W.F."]}},{"source":"PDB","id":"4EGR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2011","submissionDatabase":"PDB data bank","title":"1.70 Angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase(AroA) from Coxiella burnetii in complex with shikimate-3-phosphate and glyphosate.","authoringGroup":["Center for Structural Genomics of Infectious Diseases (CSGID)"],"authors":["Light S.H.","Minasov G.","Filippova E.V.","Krishna S.N.","Shuvalova L.","Papazisi L.","Anderson W.F."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"MAY-2015","submissionDatabase":"PDB data bank","title":"2.55 Angstrom resolution structure of 3-phosphoshikimate 1-carboxyvinyltransferase (AroA) from Coxiella burnetii in complex with shikimate-3-phosphate, phosphate, and potassium.","authors":["Light S.H.","Minasov G.","Krishna S.N.","Kwon K.","Anderson W.F."]}},{"source":"PDB","id":"3SLH","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZND","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---