4ZLA
Bestatin complex structure of leucine aminopeptidase from Helicobacter pylori
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006508 | biological_process | proteolysis |
A | 0008235 | molecular_function | metalloexopeptidase activity |
A | 0019538 | biological_process | protein metabolic process |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070006 | molecular_function | metalloaminopeptidase activity |
B | 0004177 | molecular_function | aminopeptidase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006508 | biological_process | proteolysis |
B | 0008235 | molecular_function | metalloexopeptidase activity |
B | 0019538 | biological_process | protein metabolic process |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070006 | molecular_function | metalloaminopeptidase activity |
C | 0004177 | molecular_function | aminopeptidase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006508 | biological_process | proteolysis |
C | 0008235 | molecular_function | metalloexopeptidase activity |
C | 0019538 | biological_process | protein metabolic process |
C | 0030145 | molecular_function | manganese ion binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0070006 | molecular_function | metalloaminopeptidase activity |
D | 0004177 | molecular_function | aminopeptidase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006508 | biological_process | proteolysis |
D | 0008235 | molecular_function | metalloexopeptidase activity |
D | 0019538 | biological_process | protein metabolic process |
D | 0030145 | molecular_function | manganese ion binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0070006 | molecular_function | metalloaminopeptidase activity |
E | 0004177 | molecular_function | aminopeptidase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0006508 | biological_process | proteolysis |
E | 0008235 | molecular_function | metalloexopeptidase activity |
E | 0019538 | biological_process | protein metabolic process |
E | 0030145 | molecular_function | manganese ion binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0070006 | molecular_function | metalloaminopeptidase activity |
F | 0004177 | molecular_function | aminopeptidase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006508 | biological_process | proteolysis |
F | 0008235 | molecular_function | metalloexopeptidase activity |
F | 0019538 | biological_process | protein metabolic process |
F | 0030145 | molecular_function | manganese ion binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | LYS258 |
A | ASP263 |
A | ASP281 |
A | GLU342 |
A | ZN502 |
A | BCT504 |
A | BES505 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue ZN A 502 |
Chain | Residue |
A | GLU342 |
A | ZN501 |
A | BES505 |
A | ASP263 |
A | ASP340 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue NA A 503 |
Chain | Residue |
A | ALA461 |
A | GLY462 |
A | TYR465 |
A | HOH611 |
A | HOH627 |
A | HOH912 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue BCT A 504 |
Chain | Residue |
A | LYS258 |
A | ALA341 |
A | GLU342 |
A | GLY343 |
A | ARG344 |
A | LEU368 |
A | ZN501 |
A | BES505 |
site_id | AC5 |
Number of Residues | 19 |
Details | binding site for residue BES A 505 |
Chain | Residue |
A | LYS258 |
A | ASP263 |
A | LYS270 |
A | ASP281 |
A | ASP340 |
A | GLU342 |
A | THR367 |
A | LEU368 |
A | THR369 |
A | GLY370 |
A | ILE428 |
A | ALA461 |
A | ZN501 |
A | ZN502 |
A | BCT504 |
A | HOH604 |
A | HOH614 |
A | HOH747 |
A | HOH836 |
site_id | AC6 |
Number of Residues | 7 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | LYS258 |
B | ASP263 |
B | ASP281 |
B | GLU342 |
B | ZN502 |
B | BCT504 |
B | BES505 |
site_id | AC7 |
Number of Residues | 5 |
Details | binding site for residue ZN B 502 |
Chain | Residue |
B | ASP263 |
B | ASP340 |
B | GLU342 |
B | ZN501 |
B | BES505 |
site_id | AC8 |
Number of Residues | 6 |
Details | binding site for residue NA B 503 |
Chain | Residue |
B | ALA461 |
B | GLY462 |
B | TYR465 |
B | HOH647 |
B | HOH681 |
B | HOH931 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue BCT B 504 |
Chain | Residue |
B | LYS258 |
B | ALA341 |
B | GLU342 |
B | GLY343 |
B | ARG344 |
B | LEU368 |
B | ZN501 |
B | BES505 |
site_id | AD1 |
Number of Residues | 17 |
Details | binding site for residue BES B 505 |
Chain | Residue |
B | LYS258 |
B | ASP263 |
B | LYS270 |
B | ASP281 |
B | ASP340 |
B | GLU342 |
B | THR367 |
B | LEU368 |
B | THR369 |
B | GLY370 |
B | ALA461 |
B | ZN501 |
B | ZN502 |
B | BCT504 |
B | HOH733 |
B | HOH754 |
B | HOH765 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue ZN C 501 |
Chain | Residue |
C | LYS258 |
C | ASP263 |
C | ASP281 |
C | GLU342 |
C | ZN502 |
C | BCT504 |
C | BES505 |
site_id | AD3 |
Number of Residues | 5 |
Details | binding site for residue ZN C 502 |
Chain | Residue |
C | BES505 |
C | ASP263 |
C | ASP340 |
C | GLU342 |
C | ZN501 |
site_id | AD4 |
Number of Residues | 6 |
Details | binding site for residue NA C 503 |
Chain | Residue |
C | ALA461 |
C | GLY462 |
C | TYR465 |
C | HOH2562 |
C | HOH2571 |
C | HOH2787 |
site_id | AD5 |
Number of Residues | 8 |
Details | binding site for residue BCT C 504 |
Chain | Residue |
C | LYS258 |
C | ALA341 |
C | GLU342 |
C | GLY343 |
C | ARG344 |
C | LEU368 |
C | ZN501 |
C | BES505 |
site_id | AD6 |
Number of Residues | 18 |
Details | binding site for residue BES C 505 |
Chain | Residue |
C | LYS258 |
C | ASP263 |
C | LYS270 |
C | ASP281 |
C | ASP340 |
C | GLU342 |
C | THR367 |
C | LEU368 |
C | THR369 |
C | GLY370 |
C | ALA461 |
C | ZN501 |
C | ZN502 |
C | BCT504 |
C | HOH2543 |
C | HOH2601 |
C | HOH2615 |
C | HOH2787 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue ZN D 501 |
Chain | Residue |
D | LYS258 |
D | ASP263 |
D | ASP281 |
D | GLU342 |
D | ZN502 |
D | BCT504 |
D | BES505 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue ZN D 502 |
Chain | Residue |
D | ASP263 |
D | ASP340 |
D | GLU342 |
D | ZN501 |
D | BES505 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue NA D 503 |
Chain | Residue |
D | ALA461 |
D | GLY462 |
D | TYR465 |
D | HOH618 |
D | HOH692 |
D | HOH935 |
site_id | AE1 |
Number of Residues | 8 |
Details | binding site for residue BCT D 504 |
Chain | Residue |
D | LYS258 |
D | ALA341 |
D | GLU342 |
D | GLY343 |
D | ARG344 |
D | LEU368 |
D | ZN501 |
D | BES505 |
site_id | AE2 |
Number of Residues | 15 |
Details | binding site for residue BES D 505 |
Chain | Residue |
D | LYS258 |
D | ASP263 |
D | LYS270 |
D | ASP281 |
D | ASP340 |
D | GLU342 |
D | THR367 |
D | LEU368 |
D | THR369 |
D | GLY370 |
D | ALA461 |
D | ZN501 |
D | ZN502 |
D | BCT504 |
D | HOH653 |
site_id | AE3 |
Number of Residues | 7 |
Details | binding site for residue ZN E 501 |
Chain | Residue |
E | LYS258 |
E | ASP263 |
E | ASP281 |
E | GLU342 |
E | ZN502 |
E | BCT504 |
E | BES505 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue ZN E 502 |
Chain | Residue |
E | ASP263 |
E | ASP340 |
E | GLU342 |
E | ZN501 |
E | BES505 |
site_id | AE5 |
Number of Residues | 6 |
Details | binding site for residue NA E 503 |
Chain | Residue |
E | ALA461 |
E | GLY462 |
E | TYR465 |
E | HOH634 |
E | HOH856 |
E | HOH923 |
site_id | AE6 |
Number of Residues | 8 |
Details | binding site for residue BCT E 504 |
Chain | Residue |
E | LYS258 |
E | ALA341 |
E | GLU342 |
E | GLY343 |
E | ARG344 |
E | LEU368 |
E | ZN501 |
E | BES505 |
site_id | AE7 |
Number of Residues | 16 |
Details | binding site for residue BES E 505 |
Chain | Residue |
E | LYS258 |
E | ASP263 |
E | LYS270 |
E | MET278 |
E | ASP281 |
E | ASP340 |
E | GLU342 |
E | THR367 |
E | LEU368 |
E | THR369 |
E | GLY370 |
E | ILE428 |
E | ZN501 |
E | ZN502 |
E | BCT504 |
E | HOH632 |
site_id | AE8 |
Number of Residues | 7 |
Details | binding site for residue ZN F 501 |
Chain | Residue |
F | LYS258 |
F | ASP263 |
F | ASP281 |
F | GLU342 |
F | ZN502 |
F | BCT504 |
F | BES505 |
site_id | AE9 |
Number of Residues | 5 |
Details | binding site for residue ZN F 502 |
Chain | Residue |
F | ASP263 |
F | ASP340 |
F | GLU342 |
F | ZN501 |
F | BES505 |
site_id | AF1 |
Number of Residues | 6 |
Details | binding site for residue NA F 503 |
Chain | Residue |
F | ALA461 |
F | GLY462 |
F | TYR465 |
F | HOH614 |
F | HOH878 |
F | HOH919 |
site_id | AF2 |
Number of Residues | 8 |
Details | binding site for residue BCT F 504 |
Chain | Residue |
F | LYS258 |
F | ALA341 |
F | GLU342 |
F | GLY343 |
F | ARG344 |
F | LEU368 |
F | ZN501 |
F | BES505 |
site_id | AF3 |
Number of Residues | 15 |
Details | binding site for residue BES F 505 |
Chain | Residue |
F | LYS258 |
F | ASP263 |
F | LYS270 |
F | ASP281 |
F | ASP340 |
F | GLU342 |
F | THR367 |
F | LEU368 |
F | THR369 |
F | GLY370 |
F | ALA461 |
F | ZN501 |
F | ZN502 |
F | BCT504 |
F | HOH625 |
Functional Information from PROSITE/UniProt
site_id | PS00631 |
Number of Residues | 8 |
Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
Chain | Residue | Details |
A | ASN338-LEU345 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: ACT_SITE => ECO:0000255 |
Chain | Residue | Details |
A | LYS270 | |
E | ARG344 | |
F | LYS270 | |
F | ARG344 | |
A | ARG344 | |
B | LYS270 | |
B | ARG344 | |
C | LYS270 | |
C | ARG344 | |
D | LYS270 | |
D | ARG344 | |
E | LYS270 |
site_id | SWS_FT_FI2 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LYS258 | |
B | GLU342 | |
C | LYS258 | |
C | ASP263 | |
C | ASP281 | |
C | ASP340 | |
C | GLU342 | |
D | LYS258 | |
D | ASP263 | |
D | ASP281 | |
D | ASP340 | |
A | ASP263 | |
D | GLU342 | |
E | LYS258 | |
E | ASP263 | |
E | ASP281 | |
E | ASP340 | |
E | GLU342 | |
F | LYS258 | |
F | ASP263 | |
F | ASP281 | |
F | ASP340 | |
A | ASP281 | |
F | GLU342 | |
A | ASP340 | |
A | GLU342 | |
B | LYS258 | |
B | ASP263 | |
B | ASP281 | |
B | ASP340 |