4ZLA
Bestatin complex structure of leucine aminopeptidase from Helicobacter pylori
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006508 | biological_process | proteolysis |
| A | 0008235 | molecular_function | metalloexopeptidase activity |
| A | 0019538 | biological_process | protein metabolic process |
| A | 0030145 | molecular_function | manganese ion binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070006 | molecular_function | metalloaminopeptidase activity |
| B | 0004177 | molecular_function | aminopeptidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006508 | biological_process | proteolysis |
| B | 0008235 | molecular_function | metalloexopeptidase activity |
| B | 0019538 | biological_process | protein metabolic process |
| B | 0030145 | molecular_function | manganese ion binding |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0070006 | molecular_function | metalloaminopeptidase activity |
| C | 0004177 | molecular_function | aminopeptidase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006508 | biological_process | proteolysis |
| C | 0008235 | molecular_function | metalloexopeptidase activity |
| C | 0019538 | biological_process | protein metabolic process |
| C | 0030145 | molecular_function | manganese ion binding |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0070006 | molecular_function | metalloaminopeptidase activity |
| D | 0004177 | molecular_function | aminopeptidase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006508 | biological_process | proteolysis |
| D | 0008235 | molecular_function | metalloexopeptidase activity |
| D | 0019538 | biological_process | protein metabolic process |
| D | 0030145 | molecular_function | manganese ion binding |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0070006 | molecular_function | metalloaminopeptidase activity |
| E | 0004177 | molecular_function | aminopeptidase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006508 | biological_process | proteolysis |
| E | 0008235 | molecular_function | metalloexopeptidase activity |
| E | 0019538 | biological_process | protein metabolic process |
| E | 0030145 | molecular_function | manganese ion binding |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0070006 | molecular_function | metalloaminopeptidase activity |
| F | 0004177 | molecular_function | aminopeptidase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006508 | biological_process | proteolysis |
| F | 0008235 | molecular_function | metalloexopeptidase activity |
| F | 0019538 | biological_process | protein metabolic process |
| F | 0030145 | molecular_function | manganese ion binding |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue ZN A 501 |
| Chain | Residue |
| A | LYS258 |
| A | ASP263 |
| A | ASP281 |
| A | GLU342 |
| A | ZN502 |
| A | BCT504 |
| A | BES505 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 502 |
| Chain | Residue |
| A | GLU342 |
| A | ZN501 |
| A | BES505 |
| A | ASP263 |
| A | ASP340 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 503 |
| Chain | Residue |
| A | ALA461 |
| A | GLY462 |
| A | TYR465 |
| A | HOH611 |
| A | HOH627 |
| A | HOH912 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | binding site for residue BCT A 504 |
| Chain | Residue |
| A | LYS258 |
| A | ALA341 |
| A | GLU342 |
| A | GLY343 |
| A | ARG344 |
| A | LEU368 |
| A | ZN501 |
| A | BES505 |
| site_id | AC5 |
| Number of Residues | 19 |
| Details | binding site for residue BES A 505 |
| Chain | Residue |
| A | LYS258 |
| A | ASP263 |
| A | LYS270 |
| A | ASP281 |
| A | ASP340 |
| A | GLU342 |
| A | THR367 |
| A | LEU368 |
| A | THR369 |
| A | GLY370 |
| A | ILE428 |
| A | ALA461 |
| A | ZN501 |
| A | ZN502 |
| A | BCT504 |
| A | HOH604 |
| A | HOH614 |
| A | HOH747 |
| A | HOH836 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue ZN B 501 |
| Chain | Residue |
| B | LYS258 |
| B | ASP263 |
| B | ASP281 |
| B | GLU342 |
| B | ZN502 |
| B | BCT504 |
| B | BES505 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 502 |
| Chain | Residue |
| B | ASP263 |
| B | ASP340 |
| B | GLU342 |
| B | ZN501 |
| B | BES505 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 503 |
| Chain | Residue |
| B | ALA461 |
| B | GLY462 |
| B | TYR465 |
| B | HOH647 |
| B | HOH681 |
| B | HOH931 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | binding site for residue BCT B 504 |
| Chain | Residue |
| B | LYS258 |
| B | ALA341 |
| B | GLU342 |
| B | GLY343 |
| B | ARG344 |
| B | LEU368 |
| B | ZN501 |
| B | BES505 |
| site_id | AD1 |
| Number of Residues | 17 |
| Details | binding site for residue BES B 505 |
| Chain | Residue |
| B | LYS258 |
| B | ASP263 |
| B | LYS270 |
| B | ASP281 |
| B | ASP340 |
| B | GLU342 |
| B | THR367 |
| B | LEU368 |
| B | THR369 |
| B | GLY370 |
| B | ALA461 |
| B | ZN501 |
| B | ZN502 |
| B | BCT504 |
| B | HOH733 |
| B | HOH754 |
| B | HOH765 |
| site_id | AD2 |
| Number of Residues | 7 |
| Details | binding site for residue ZN C 501 |
| Chain | Residue |
| C | LYS258 |
| C | ASP263 |
| C | ASP281 |
| C | GLU342 |
| C | ZN502 |
| C | BCT504 |
| C | BES505 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 502 |
| Chain | Residue |
| C | BES505 |
| C | ASP263 |
| C | ASP340 |
| C | GLU342 |
| C | ZN501 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue NA C 503 |
| Chain | Residue |
| C | ALA461 |
| C | GLY462 |
| C | TYR465 |
| C | HOH2562 |
| C | HOH2571 |
| C | HOH2787 |
| site_id | AD5 |
| Number of Residues | 8 |
| Details | binding site for residue BCT C 504 |
| Chain | Residue |
| C | LYS258 |
| C | ALA341 |
| C | GLU342 |
| C | GLY343 |
| C | ARG344 |
| C | LEU368 |
| C | ZN501 |
| C | BES505 |
| site_id | AD6 |
| Number of Residues | 18 |
| Details | binding site for residue BES C 505 |
| Chain | Residue |
| C | LYS258 |
| C | ASP263 |
| C | LYS270 |
| C | ASP281 |
| C | ASP340 |
| C | GLU342 |
| C | THR367 |
| C | LEU368 |
| C | THR369 |
| C | GLY370 |
| C | ALA461 |
| C | ZN501 |
| C | ZN502 |
| C | BCT504 |
| C | HOH2543 |
| C | HOH2601 |
| C | HOH2615 |
| C | HOH2787 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue ZN D 501 |
| Chain | Residue |
| D | LYS258 |
| D | ASP263 |
| D | ASP281 |
| D | GLU342 |
| D | ZN502 |
| D | BCT504 |
| D | BES505 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue ZN D 502 |
| Chain | Residue |
| D | ASP263 |
| D | ASP340 |
| D | GLU342 |
| D | ZN501 |
| D | BES505 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue NA D 503 |
| Chain | Residue |
| D | ALA461 |
| D | GLY462 |
| D | TYR465 |
| D | HOH618 |
| D | HOH692 |
| D | HOH935 |
| site_id | AE1 |
| Number of Residues | 8 |
| Details | binding site for residue BCT D 504 |
| Chain | Residue |
| D | LYS258 |
| D | ALA341 |
| D | GLU342 |
| D | GLY343 |
| D | ARG344 |
| D | LEU368 |
| D | ZN501 |
| D | BES505 |
| site_id | AE2 |
| Number of Residues | 15 |
| Details | binding site for residue BES D 505 |
| Chain | Residue |
| D | LYS258 |
| D | ASP263 |
| D | LYS270 |
| D | ASP281 |
| D | ASP340 |
| D | GLU342 |
| D | THR367 |
| D | LEU368 |
| D | THR369 |
| D | GLY370 |
| D | ALA461 |
| D | ZN501 |
| D | ZN502 |
| D | BCT504 |
| D | HOH653 |
| site_id | AE3 |
| Number of Residues | 7 |
| Details | binding site for residue ZN E 501 |
| Chain | Residue |
| E | LYS258 |
| E | ASP263 |
| E | ASP281 |
| E | GLU342 |
| E | ZN502 |
| E | BCT504 |
| E | BES505 |
| site_id | AE4 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 502 |
| Chain | Residue |
| E | ASP263 |
| E | ASP340 |
| E | GLU342 |
| E | ZN501 |
| E | BES505 |
| site_id | AE5 |
| Number of Residues | 6 |
| Details | binding site for residue NA E 503 |
| Chain | Residue |
| E | ALA461 |
| E | GLY462 |
| E | TYR465 |
| E | HOH634 |
| E | HOH856 |
| E | HOH923 |
| site_id | AE6 |
| Number of Residues | 8 |
| Details | binding site for residue BCT E 504 |
| Chain | Residue |
| E | LYS258 |
| E | ALA341 |
| E | GLU342 |
| E | GLY343 |
| E | ARG344 |
| E | LEU368 |
| E | ZN501 |
| E | BES505 |
| site_id | AE7 |
| Number of Residues | 16 |
| Details | binding site for residue BES E 505 |
| Chain | Residue |
| E | LYS258 |
| E | ASP263 |
| E | LYS270 |
| E | MET278 |
| E | ASP281 |
| E | ASP340 |
| E | GLU342 |
| E | THR367 |
| E | LEU368 |
| E | THR369 |
| E | GLY370 |
| E | ILE428 |
| E | ZN501 |
| E | ZN502 |
| E | BCT504 |
| E | HOH632 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue ZN F 501 |
| Chain | Residue |
| F | LYS258 |
| F | ASP263 |
| F | ASP281 |
| F | GLU342 |
| F | ZN502 |
| F | BCT504 |
| F | BES505 |
| site_id | AE9 |
| Number of Residues | 5 |
| Details | binding site for residue ZN F 502 |
| Chain | Residue |
| F | ASP263 |
| F | ASP340 |
| F | GLU342 |
| F | ZN501 |
| F | BES505 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 503 |
| Chain | Residue |
| F | ALA461 |
| F | GLY462 |
| F | TYR465 |
| F | HOH614 |
| F | HOH878 |
| F | HOH919 |
| site_id | AF2 |
| Number of Residues | 8 |
| Details | binding site for residue BCT F 504 |
| Chain | Residue |
| F | LYS258 |
| F | ALA341 |
| F | GLU342 |
| F | GLY343 |
| F | ARG344 |
| F | LEU368 |
| F | ZN501 |
| F | BES505 |
| site_id | AF3 |
| Number of Residues | 15 |
| Details | binding site for residue BES F 505 |
| Chain | Residue |
| F | LYS258 |
| F | ASP263 |
| F | LYS270 |
| F | ASP281 |
| F | ASP340 |
| F | GLU342 |
| F | THR367 |
| F | LEU368 |
| F | THR369 |
| F | GLY370 |
| F | ALA461 |
| F | ZN501 |
| F | ZN502 |
| F | BCT504 |
| F | HOH625 |
Functional Information from PROSITE/UniProt
| site_id | PS00631 |
| Number of Residues | 8 |
| Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
| Chain | Residue | Details |
| A | ASN338-LEU345 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 12 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255 |
| Chain | Residue | Details |
| A | LYS270 | |
| A | ARG344 | |
| B | LYS270 | |
| B | ARG344 | |
| C | LYS270 | |
| C | ARG344 | |
| D | LYS270 | |
| D | ARG344 | |
| E | LYS270 | |
| E | ARG344 | |
| F | LYS270 | |
| F | ARG344 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| E | GLU342 | |
| F | LYS258 | |
| F | ASP263 | |
| F | ASP281 | |
| F | ASP340 | |
| F | GLU342 | |
| A | LYS258 | |
| A | ASP263 | |
| A | ASP281 | |
| A | ASP340 | |
| A | GLU342 | |
| B | LYS258 | |
| B | ASP263 | |
| B | ASP281 | |
| B | ASP340 | |
| B | GLU342 | |
| C | LYS258 | |
| C | ASP263 | |
| C | ASP281 | |
| C | ASP340 | |
| C | GLU342 | |
| D | LYS258 | |
| D | ASP263 | |
| D | ASP281 | |
| D | ASP340 | |
| D | GLU342 | |
| E | LYS258 | |
| E | ASP263 | |
| E | ASP281 | |
| E | ASP340 |
