4ZKT

Crystal structure of the progenitor M complex of Clostridium botulinum type E neurotoxin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005576	cellular_component	extracellular region
A	0006508	biological_process	proteolysis
A	0008270	molecular_function	zinc ion binding
A	0008320	molecular_function	transmembrane protein transporter activity
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0044164	cellular_component	host cell cytosol
A	0044231	cellular_component	host cell presynaptic membrane
A	0071806	biological_process	protein transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005576	cellular_component	extracellular region
B	0006508	biological_process	proteolysis
B	0008270	molecular_function	zinc ion binding
C	0004222	molecular_function	metalloendopeptidase activity
C	0005576	cellular_component	extracellular region
C	0006508	biological_process	proteolysis
C	0008270	molecular_function	zinc ion binding
C	0008320	molecular_function	transmembrane protein transporter activity
C	0044161	cellular_component	host cell cytoplasmic vesicle
C	0044164	cellular_component	host cell cytosol
C	0044231	cellular_component	host cell presynaptic membrane
C	0071806	biological_process	protein transmembrane transport
D	0004222	molecular_function	metalloendopeptidase activity
D	0005576	cellular_component	extracellular region
D	0006508	biological_process	proteolysis
D	0008270	molecular_function	zinc ion binding
E	0004222	molecular_function	metalloendopeptidase activity
E	0005576	cellular_component	extracellular region
E	0006508	biological_process	proteolysis
E	0008270	molecular_function	zinc ion binding
E	0008320	molecular_function	transmembrane protein transporter activity
E	0044161	cellular_component	host cell cytoplasmic vesicle
E	0044164	cellular_component	host cell cytosol
E	0044231	cellular_component	host cell presynaptic membrane
E	0071806	biological_process	protein transmembrane transport
F	0004222	molecular_function	metalloendopeptidase activity
F	0005576	cellular_component	extracellular region
F	0006508	biological_process	proteolysis
F	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 1301

Chain	Residue
A	HIS212
A	GLU213
A	HIS216
A	GLU251
A	TYR351

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site_id	AC2
Number of Residues	5
Details	binding site for residue ZN C 1301

Chain	Residue
C	TYR351
C	HIS212
C	GLU213
C	HIS216
C	GLU251

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site_id	AC3
Number of Residues	5
Details	binding site for residue ZN E 1301

Chain	Residue
E	HIS212
E	GLU213
E	HIS216
E	GLU251
E	TYR351

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TLMHELIHSL

Chain	Residue	Details
A	THR209-LEU218

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