4ZKN

The crystal structure of upain-1-W3A in complex with uPA at pH5.5

Functional Information from GO Data

Chain	GOid	namespace	contents
U	0004252	molecular_function	serine-type endopeptidase activity
U	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue SO4 U 301

Chain	Residue
U	LYS62
U	ASN87
U	PRO170
U	HIS170
U	HOH436

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site_id	AC2
Number of Residues	8
Details	binding site for residue PG4 U 302

Chain	Residue
U	TRP51
U	ALA112
U	PRO114
U	HOH460
P	SER2
U	SER48
U	PRO49
U	CYS50

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site_id	AC3
Number of Residues	12
Details	binding site for residue PG4 U 303

Chain	Residue
U	TRP51
U	ILE89
U	LYS92
U	LYS107
U	GLN169
U	PRO170
U	GLY173
U	SER174
U	HIS241
U	HOH448
U	HOH489
U	HOH528

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. ISATHC

Chain	Residue	Details
U	ILE53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
U	ASP189-VAL200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
U	HIS57
U	ASP102
U	SER195

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:9151681

Chain	Residue	Details
U	SER146

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine

Chain	Residue	Details
U	GLN145

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