4ZK4

Crystal structure of a chimeric acetylcholine binding protein from Aplysia californica (Ac-AChBP) containing loop C from the human alpha 3 nicotinic acetylcholine receptor in complex with 7-(5-isopropoxy-pyridin-3-yl)-1-methyl-1,7-diaza-spiro[4.4]nonane

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue MG A 301

Chain	Residue
A	ASP-3
A	HIS1

---

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 302

Chain	Residue
A	ARG97
A	HOH422
A	HOH423
A	HOH425
E	LYS42

---

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 303

Chain	Residue
B	ARG97
B	HOH412
A	LYS42
A	HOH475

---

site_id	AC4
Number of Residues	4
Details	binding site for residue PG4 A 304

Chain	Residue
A	TRP147
A	TYR188
A	HOH402
A	HOH487

---

site_id	AC5
Number of Residues	4
Details	binding site for residue SO4 B 301

Chain	Residue
B	LYS42
B	HOH408
C	ARG97
C	HOH413

---

site_id	AC6
Number of Residues	11
Details	binding site for residue TII C 301

Chain	Residue
B	TRP55
B	ARG79
B	VAL108
C	TYR93
C	SER146
C	TRP147
C	VAL148
C	CYS190
C	CYS191
C	TYR195
C	HOH424

---

site_id	AC7
Number of Residues	4
Details	binding site for residue SO4 C 302

Chain	Residue
C	LYS42
C	HOH419
D	ARG97
D	HOH409

---

site_id	AC8
Number of Residues	4
Details	binding site for residue SO4 D 301

Chain	Residue
D	LYS42
D	HOH406
E	ARG97
E	HOH420

---

site_id	AC9
Number of Residues	11
Details	binding site for residue TII E 301

Chain	Residue
D	TRP55
D	ARG79
D	VAL108
D	ILE118
E	SER146
E	TRP147
E	VAL148
E	CYS190
E	CYS191
E	TYR195
E	HOH413

---

site_id	AD1
Number of Residues	2
Details	binding site for residue MG E 302

Chain	Residue
E	ASP-3
E	HIS1

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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