Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZJT

X-ray crystal structure of Lymnaea stagnalis acetylcholine binding protein (LsAChBP) in complex with 2-Thiophenylmethylene Anabaseine (2TAB)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005576	cellular_component	extracellular region
A	0006811	biological_process	monoatomic ion transport
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0043083	cellular_component	synaptic cleft
A	0045202	cellular_component	synapse
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005576	cellular_component	extracellular region
B	0006811	biological_process	monoatomic ion transport
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0043083	cellular_component	synaptic cleft
B	0045202	cellular_component	synapse
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005576	cellular_component	extracellular region
C	0006811	biological_process	monoatomic ion transport
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0043083	cellular_component	synaptic cleft
C	0045202	cellular_component	synapse
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005576	cellular_component	extracellular region
D	0006811	biological_process	monoatomic ion transport
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0043083	cellular_component	synaptic cleft
D	0045202	cellular_component	synapse
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005576	cellular_component	extracellular region
E	0006811	biological_process	monoatomic ion transport
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0043083	cellular_component	synaptic cleft
E	0045202	cellular_component	synapse
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0005576	cellular_component	extracellular region
F	0006811	biological_process	monoatomic ion transport
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0043083	cellular_component	synaptic cleft
F	0045202	cellular_component	synapse
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0005576	cellular_component	extracellular region
G	0006811	biological_process	monoatomic ion transport
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0043083	cellular_component	synaptic cleft
G	0045202	cellular_component	synapse
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0005576	cellular_component	extracellular region
H	0006811	biological_process	monoatomic ion transport
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0043083	cellular_component	synaptic cleft
H	0045202	cellular_component	synapse
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0005576	cellular_component	extracellular region
I	0006811	biological_process	monoatomic ion transport
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0043083	cellular_component	synaptic cleft
I	0045202	cellular_component	synapse
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0005576	cellular_component	extracellular region
J	0006811	biological_process	monoatomic ion transport
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0043083	cellular_component	synaptic cleft
J	0045202	cellular_component	synapse

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue PO4 A 301

Chain	Residue
A	ARG3
A	VAL74
A	SER75
E	ASP17
E	VAL18
E	ILE19
E	HIS145

site_id	AC2
Number of Residues	7
Details	binding site for residue PO4 A 302

Chain	Residue
A	ILE19
A	HIS145
B	ARG3
B	VAL74
B	SER75
A	ASP17
A	VAL18

site_id	AC3
Number of Residues	8
Details	binding site for residue 4P6 A 303

Chain	Residue
A	TYR89
A	TRP143
A	TYR185
A	TYR192
A	HOH434
B	GLN55
B	LEU112
B	MET114

site_id	AC4
Number of Residues	7
Details	binding site for residue PO4 B 301

Chain	Residue
B	ASP17
B	VAL18
B	ILE19
B	HIS145
C	ARG3
C	VAL74
C	SER75

site_id	AC5
Number of Residues	8
Details	binding site for residue 4P6 B 302

Chain	Residue
B	TRP143
B	TYR185
B	CYS187
B	TYR192
B	HOH452
C	LEU112
C	MET114
C	TYR164

site_id	AC6
Number of Residues	7
Details	binding site for residue PO4 C 301

Chain	Residue
C	ASP17
C	VAL18
C	ILE19
C	HIS145
D	ARG3
D	VAL74
D	SER75

site_id	AC7
Number of Residues	10
Details	binding site for residue 4P6 C 302

Chain	Residue
C	TYR89
C	TRP143
C	TYR185
C	SER186
C	CYS187
C	TYR192
C	HOH438
D	TRP53
D	GLN55
D	MET114

site_id	AC8
Number of Residues	8
Details	binding site for residue PO4 D 301

Chain	Residue
D	ASP17
D	VAL18
D	ILE19
D	HIS145
D	HOH444
E	ARG3
E	VAL74
E	SER75

site_id	AC9
Number of Residues	8
Details	binding site for residue 4P6 D 302

Chain	Residue
D	TRP143
D	TYR185
D	CYS187
D	TYR192
E	LEU112
E	MET114
E	TYR164
E	HOH426

site_id	AD1
Number of Residues	9
Details	binding site for residue 4P6 E 301

Chain	Residue
A	TRP53
A	GLN55
A	LEU112
A	MET114
A	TYR164
A	HOH433
E	TYR89
E	TRP143
E	TYR192

site_id	AD2
Number of Residues	9
Details	binding site for residue 4P6 F 301

Chain	Residue
F	TYR89
F	TRP143
F	TYR185
F	CYS187
F	TYR192
G	LEU112
G	MET114
G	TYR164
G	HOH436

site_id	AD3
Number of Residues	7
Details	binding site for residue PO4 G 301

Chain	Residue
F	ASP17
F	VAL18
F	ILE19
F	HIS145
G	ARG3
G	VAL74
G	SER75

site_id	AD4
Number of Residues	7
Details	binding site for residue PO4 G 302

Chain	Residue
H	ARG3
H	VAL74
H	SER75
G	ASP17
G	VAL18
G	ILE19
G	HIS145

site_id	AD5
Number of Residues	10
Details	binding site for residue 4P6 G 303

Chain	Residue
G	TYR89
G	TRP143
G	TYR185
G	CYS187
G	TYR192
G	HOH430
H	GLN55
H	LEU112
H	MET114
H	TYR164

site_id	AD6
Number of Residues	8
Details	binding site for residue 4P6 H 301

Chain	Residue
H	TRP143
H	TYR185
H	CYS187
H	TYR192
H	HOH424
I	LEU112
I	MET114
I	TYR164

site_id	AD7
Number of Residues	7
Details	binding site for residue PO4 I 301

Chain	Residue
H	ASP17
H	VAL18
H	ILE19
H	HIS145
I	ARG3
I	VAL74
I	SER75

site_id	AD8
Number of Residues	7
Details	binding site for residue PO4 I 302

Chain	Residue
I	ASP17
I	VAL18
I	ILE19
I	HIS145
J	ARG3
J	VAL74
J	SER75

site_id	AD9
Number of Residues	9
Details	binding site for residue 4P6 I 303

Chain	Residue
I	TRP143
I	TYR185
I	CYS187
I	TYR192
J	GLN55
J	LEU112
J	MET114
J	TYR164
J	HOH438

site_id	AE1
Number of Residues	6
Details	binding site for residue PO4 J 301

Chain	Residue
F	ARG3
F	SER75
J	ASP17
J	VAL18
J	ILE19
J	HIS145

site_id	AE2
Number of Residues	7
Details	binding site for residue 4P6 J 302

Chain	Residue
F	MET114
F	TYR164
F	HOH438
J	TRP143
J	TYR185
J	CYS187
J	TYR192

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN66
J	ASN66
B	ASN66
C	ASN66
D	ASN66
E	ASN66
F	ASN66
G	ASN66
H	ASN66
I	ASN66

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)