4ZI6
Crystal structure of leucine aminopeptidase from Helicobacter pylori
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004177 | molecular_function | aminopeptidase activity |
A | 0005737 | cellular_component | cytoplasm |
A | 0006508 | biological_process | proteolysis |
A | 0008235 | molecular_function | metalloexopeptidase activity |
A | 0019538 | biological_process | protein metabolic process |
A | 0030145 | molecular_function | manganese ion binding |
A | 0046872 | molecular_function | metal ion binding |
A | 0070006 | molecular_function | metalloaminopeptidase activity |
B | 0004177 | molecular_function | aminopeptidase activity |
B | 0005737 | cellular_component | cytoplasm |
B | 0006508 | biological_process | proteolysis |
B | 0008235 | molecular_function | metalloexopeptidase activity |
B | 0019538 | biological_process | protein metabolic process |
B | 0030145 | molecular_function | manganese ion binding |
B | 0046872 | molecular_function | metal ion binding |
B | 0070006 | molecular_function | metalloaminopeptidase activity |
C | 0004177 | molecular_function | aminopeptidase activity |
C | 0005737 | cellular_component | cytoplasm |
C | 0006508 | biological_process | proteolysis |
C | 0008235 | molecular_function | metalloexopeptidase activity |
C | 0019538 | biological_process | protein metabolic process |
C | 0030145 | molecular_function | manganese ion binding |
C | 0046872 | molecular_function | metal ion binding |
C | 0070006 | molecular_function | metalloaminopeptidase activity |
D | 0004177 | molecular_function | aminopeptidase activity |
D | 0005737 | cellular_component | cytoplasm |
D | 0006508 | biological_process | proteolysis |
D | 0008235 | molecular_function | metalloexopeptidase activity |
D | 0019538 | biological_process | protein metabolic process |
D | 0030145 | molecular_function | manganese ion binding |
D | 0046872 | molecular_function | metal ion binding |
D | 0070006 | molecular_function | metalloaminopeptidase activity |
E | 0004177 | molecular_function | aminopeptidase activity |
E | 0005737 | cellular_component | cytoplasm |
E | 0006508 | biological_process | proteolysis |
E | 0008235 | molecular_function | metalloexopeptidase activity |
E | 0019538 | biological_process | protein metabolic process |
E | 0030145 | molecular_function | manganese ion binding |
E | 0046872 | molecular_function | metal ion binding |
E | 0070006 | molecular_function | metalloaminopeptidase activity |
F | 0004177 | molecular_function | aminopeptidase activity |
F | 0005737 | cellular_component | cytoplasm |
F | 0006508 | biological_process | proteolysis |
F | 0008235 | molecular_function | metalloexopeptidase activity |
F | 0019538 | biological_process | protein metabolic process |
F | 0030145 | molecular_function | manganese ion binding |
F | 0046872 | molecular_function | metal ion binding |
F | 0070006 | molecular_function | metalloaminopeptidase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue ZN A 501 |
Chain | Residue |
A | LYS258 |
A | ASP263 |
A | ASP281 |
A | GLU342 |
A | ZN502 |
A | HOH635 |
A | HOH812 |
site_id | AC2 |
Number of Residues | 6 |
Details | binding site for residue ZN A 502 |
Chain | Residue |
A | ASP340 |
A | GLU342 |
A | ZN501 |
A | HOH635 |
A | ASP263 |
A | LYS270 |
site_id | AC3 |
Number of Residues | 7 |
Details | binding site for residue BCT A 503 |
Chain | Residue |
A | LYS258 |
A | ALA341 |
A | GLU342 |
A | GLY343 |
A | ARG344 |
A | LEU368 |
A | HOH635 |
site_id | AC4 |
Number of Residues | 6 |
Details | binding site for residue NA A 504 |
Chain | Residue |
A | ALA461 |
A | GLY462 |
A | TYR465 |
A | HOH608 |
A | HOH652 |
A | HOH892 |
site_id | AC5 |
Number of Residues | 8 |
Details | binding site for residue ZN B 501 |
Chain | Residue |
B | LYS258 |
B | ASP263 |
B | ASP281 |
B | GLU342 |
B | ZN502 |
B | HOH683 |
B | HOH721 |
B | HOH813 |
site_id | AC6 |
Number of Residues | 5 |
Details | binding site for residue ZN B 502 |
Chain | Residue |
B | ASP263 |
B | ASP340 |
B | GLU342 |
B | ZN501 |
B | HOH813 |
site_id | AC7 |
Number of Residues | 8 |
Details | binding site for residue BCT B 503 |
Chain | Residue |
B | LYS258 |
B | ALA341 |
B | GLU342 |
B | GLY343 |
B | ARG344 |
B | LEU368 |
B | HOH813 |
B | HOH820 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue NA B 504 |
Chain | Residue |
B | ALA461 |
B | GLY462 |
B | TYR465 |
B | HOH614 |
B | HOH674 |
site_id | AC9 |
Number of Residues | 8 |
Details | binding site for residue ZN C 501 |
Chain | Residue |
C | LYS258 |
C | ASP263 |
C | ASP281 |
C | GLU342 |
C | ZN502 |
C | HOH648 |
C | HOH662 |
C | HOH848 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue ZN C 502 |
Chain | Residue |
C | ASP263 |
C | ASP340 |
C | GLU342 |
C | ZN501 |
C | HOH648 |
C | HOH662 |
site_id | AD2 |
Number of Residues | 7 |
Details | binding site for residue BCT C 503 |
Chain | Residue |
C | LYS258 |
C | ALA341 |
C | GLU342 |
C | GLY343 |
C | ARG344 |
C | LEU368 |
C | HOH648 |
site_id | AD3 |
Number of Residues | 6 |
Details | binding site for residue NA C 504 |
Chain | Residue |
C | ALA461 |
C | GLY462 |
C | TYR465 |
C | HOH669 |
C | HOH748 |
C | HOH869 |
site_id | AD4 |
Number of Residues | 8 |
Details | binding site for residue ZN D 501 |
Chain | Residue |
D | LYS258 |
D | ASP263 |
D | ASP281 |
D | GLU342 |
D | ZN502 |
D | BCT503 |
D | HOH698 |
D | HOH852 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue ZN D 502 |
Chain | Residue |
D | ASP263 |
D | LYS270 |
D | ASP340 |
D | GLU342 |
D | ZN501 |
D | HOH698 |
site_id | AD6 |
Number of Residues | 8 |
Details | binding site for residue BCT D 503 |
Chain | Residue |
D | ZN501 |
D | HOH698 |
D | LYS258 |
D | ALA341 |
D | GLU342 |
D | GLY343 |
D | ARG344 |
D | LEU368 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue NA D 504 |
Chain | Residue |
D | ALA461 |
D | GLY462 |
D | TYR465 |
D | HOH676 |
site_id | AD8 |
Number of Residues | 7 |
Details | binding site for residue ZN E 501 |
Chain | Residue |
E | LYS258 |
E | ASP263 |
E | ASP281 |
E | GLU342 |
E | ZN502 |
E | HOH688 |
E | HOH853 |
site_id | AD9 |
Number of Residues | 6 |
Details | binding site for residue ZN E 502 |
Chain | Residue |
E | ASP263 |
E | ASP340 |
E | GLU342 |
E | ZN501 |
E | HOH688 |
E | HOH870 |
site_id | AE1 |
Number of Residues | 7 |
Details | binding site for residue BCT E 503 |
Chain | Residue |
E | LYS258 |
E | ALA341 |
E | GLU342 |
E | GLY343 |
E | ARG344 |
E | LEU368 |
E | HOH688 |
site_id | AE2 |
Number of Residues | 6 |
Details | binding site for residue NA E 504 |
Chain | Residue |
E | ALA461 |
E | GLY462 |
E | TYR465 |
E | HOH624 |
E | HOH637 |
E | HOH908 |
site_id | AE3 |
Number of Residues | 7 |
Details | binding site for residue ZN F 501 |
Chain | Residue |
F | LYS258 |
F | ASP263 |
F | ASP281 |
F | GLU342 |
F | ZN502 |
F | HOH727 |
F | HOH874 |
site_id | AE4 |
Number of Residues | 5 |
Details | binding site for residue ZN F 502 |
Chain | Residue |
F | ASP263 |
F | ASP340 |
F | GLU342 |
F | ZN501 |
F | HOH727 |
site_id | AE5 |
Number of Residues | 7 |
Details | binding site for residue BCT F 503 |
Chain | Residue |
F | LYS258 |
F | ALA341 |
F | GLU342 |
F | GLY343 |
F | ARG344 |
F | LEU368 |
F | HOH727 |
site_id | AE6 |
Number of Residues | 4 |
Details | binding site for residue NA F 504 |
Chain | Residue |
F | ALA461 |
F | GLY462 |
F | TYR465 |
F | HOH614 |
Functional Information from PROSITE/UniProt
site_id | PS00631 |
Number of Residues | 8 |
Details | CYTOSOL_AP Cytosol aminopeptidase signature. NTDAEGRL |
Chain | Residue | Details |
A | ASN338-LEU345 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | ACT_SITE: ACT_SITE => ECO:0000255 |
Chain | Residue | Details |
A | LYS270 | |
E | ARG344 | |
F | LYS270 | |
F | ARG344 | |
A | ARG344 | |
B | LYS270 | |
B | ARG344 | |
C | LYS270 | |
C | ARG344 | |
D | LYS270 | |
D | ARG344 | |
E | LYS270 |
site_id | SWS_FT_FI2 |
Number of Residues | 30 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | LYS258 | |
B | GLU342 | |
C | LYS258 | |
C | ASP263 | |
C | ASP281 | |
C | ASP340 | |
C | GLU342 | |
D | LYS258 | |
D | ASP263 | |
D | ASP281 | |
D | ASP340 | |
A | ASP263 | |
D | GLU342 | |
E | LYS258 | |
E | ASP263 | |
E | ASP281 | |
E | ASP340 | |
E | GLU342 | |
F | LYS258 | |
F | ASP263 | |
F | ASP281 | |
F | ASP340 | |
A | ASP281 | |
F | GLU342 | |
A | ASP340 | |
A | GLU342 | |
B | LYS258 | |
B | ASP263 | |
B | ASP281 | |
B | ASP340 |