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4ZHG

Siderocalin-mediated recognition and cellular uptake of actinides

Functional Information from GO Data
ChainGOidnamespacecontents
A0002020molecular_functionprotease binding
A0002376biological_processimmune system process
A0005506molecular_functioniron ion binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006811biological_processmonoatomic ion transport
A0006826biological_processiron ion transport
A0006915biological_processapoptotic process
A0006953biological_processacute-phase response
A0006979biological_processresponse to oxidative stress
A0007614biological_processshort-term memory
A0007616biological_processlong-term memory
A0009410biological_processresponse to xenobiotic stimulus
A0009615biological_processresponse to virus
A0009617biological_processresponse to bacterium
A0009635biological_processresponse to herbicide
A0009636biological_processresponse to toxic substance
A0009637biological_processresponse to blue light
A0009750biological_processresponse to fructose
A0010040biological_processresponse to iron(II) ion
A0010046biological_processresponse to mycotoxin
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0015891biological_processsiderophore transport
A0031346biological_processpositive regulation of cell projection organization
A0031410cellular_componentcytoplasmic vesicle
A0031667biological_processresponse to nutrient levels
A0031669biological_processcellular response to nutrient levels
A0032496biological_processresponse to lipopolysaccharide
A0035580cellular_componentspecific granule lumen
A0036094molecular_functionsmall molecule binding
A0036295biological_processcellular response to increased oxygen levels
A0042742biological_processdefense response to bacterium
A0042802molecular_functionidentical protein binding
A0043065biological_processpositive regulation of apoptotic process
A0043525biological_processpositive regulation of neuron apoptotic process
A0045087biological_processinnate immune response
A0060205cellular_componentcytoplasmic vesicle lumen
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0071222biological_processcellular response to lipopolysaccharide
A0071347biological_processcellular response to interleukin-1
A0071354biological_processcellular response to interleukin-6
A0071356biological_processcellular response to tumor necrosis factor
A0071456biological_processcellular response to hypoxia
A0071481biological_processcellular response to X-ray
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0110090biological_processpositive regulation of hippocampal neuron apoptotic process
A0110091biological_processnegative regulation of hippocampal neuron apoptotic process
A0120162biological_processpositive regulation of cold-induced thermogenesis
A0140315molecular_functioniron ion sequestering activity
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1903981molecular_functionenterobactin binding
A1904373biological_processresponse to kainic acid
A1904440biological_processpositive regulation of iron ion import across plasma membrane
A1904646biological_processcellular response to amyloid-beta
A1905956biological_processpositive regulation of endothelial tube morphogenesis
A1990090biological_processcellular response to nerve growth factor stimulus
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
B0002020molecular_functionprotease binding
B0002376biological_processimmune system process
B0005506molecular_functioniron ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006811biological_processmonoatomic ion transport
B0006826biological_processiron ion transport
B0006915biological_processapoptotic process
B0006953biological_processacute-phase response
B0006979biological_processresponse to oxidative stress
B0007614biological_processshort-term memory
B0007616biological_processlong-term memory
B0009410biological_processresponse to xenobiotic stimulus
B0009615biological_processresponse to virus
B0009617biological_processresponse to bacterium
B0009635biological_processresponse to herbicide
B0009636biological_processresponse to toxic substance
B0009637biological_processresponse to blue light
B0009750biological_processresponse to fructose
B0010040biological_processresponse to iron(II) ion
B0010046biological_processresponse to mycotoxin
B0010595biological_processpositive regulation of endothelial cell migration
B0010628biological_processpositive regulation of gene expression
B0015891biological_processsiderophore transport
B0031346biological_processpositive regulation of cell projection organization
B0031410cellular_componentcytoplasmic vesicle
B0031667biological_processresponse to nutrient levels
B0031669biological_processcellular response to nutrient levels
B0032496biological_processresponse to lipopolysaccharide
B0035580cellular_componentspecific granule lumen
B0036094molecular_functionsmall molecule binding
B0036295biological_processcellular response to increased oxygen levels
B0042742biological_processdefense response to bacterium
B0042802molecular_functionidentical protein binding
B0043065biological_processpositive regulation of apoptotic process
B0043525biological_processpositive regulation of neuron apoptotic process
B0045087biological_processinnate immune response
B0060205cellular_componentcytoplasmic vesicle lumen
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0071222biological_processcellular response to lipopolysaccharide
B0071347biological_processcellular response to interleukin-1
B0071354biological_processcellular response to interleukin-6
B0071356biological_processcellular response to tumor necrosis factor
B0071456biological_processcellular response to hypoxia
B0071481biological_processcellular response to X-ray
B0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
B0110090biological_processpositive regulation of hippocampal neuron apoptotic process
B0110091biological_processnegative regulation of hippocampal neuron apoptotic process
B0120162biological_processpositive regulation of cold-induced thermogenesis
B0140315molecular_functioniron ion sequestering activity
B1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
B1903981molecular_functionenterobactin binding
B1904373biological_processresponse to kainic acid
B1904440biological_processpositive regulation of iron ion import across plasma membrane
B1904646biological_processcellular response to amyloid-beta
B1905956biological_processpositive regulation of endothelial tube morphogenesis
B1990090biological_processcellular response to nerve growth factor stimulus
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
C0002020molecular_functionprotease binding
C0002376biological_processimmune system process
C0005506molecular_functioniron ion binding
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0006811biological_processmonoatomic ion transport
C0006826biological_processiron ion transport
C0006915biological_processapoptotic process
C0006953biological_processacute-phase response
C0006979biological_processresponse to oxidative stress
C0007614biological_processshort-term memory
C0007616biological_processlong-term memory
C0009410biological_processresponse to xenobiotic stimulus
C0009615biological_processresponse to virus
C0009617biological_processresponse to bacterium
C0009635biological_processresponse to herbicide
C0009636biological_processresponse to toxic substance
C0009637biological_processresponse to blue light
C0009750biological_processresponse to fructose
C0010040biological_processresponse to iron(II) ion
C0010046biological_processresponse to mycotoxin
C0010595biological_processpositive regulation of endothelial cell migration
C0010628biological_processpositive regulation of gene expression
C0015891biological_processsiderophore transport
C0031346biological_processpositive regulation of cell projection organization
C0031410cellular_componentcytoplasmic vesicle
C0031667biological_processresponse to nutrient levels
C0031669biological_processcellular response to nutrient levels
C0032496biological_processresponse to lipopolysaccharide
C0035580cellular_componentspecific granule lumen
C0036094molecular_functionsmall molecule binding
C0036295biological_processcellular response to increased oxygen levels
C0042742biological_processdefense response to bacterium
C0042802molecular_functionidentical protein binding
C0043065biological_processpositive regulation of apoptotic process
C0043525biological_processpositive regulation of neuron apoptotic process
C0045087biological_processinnate immune response
C0060205cellular_componentcytoplasmic vesicle lumen
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0071222biological_processcellular response to lipopolysaccharide
C0071347biological_processcellular response to interleukin-1
C0071354biological_processcellular response to interleukin-6
C0071356biological_processcellular response to tumor necrosis factor
C0071456biological_processcellular response to hypoxia
C0071481biological_processcellular response to X-ray
C0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
C0110090biological_processpositive regulation of hippocampal neuron apoptotic process
C0110091biological_processnegative regulation of hippocampal neuron apoptotic process
C0120162biological_processpositive regulation of cold-induced thermogenesis
C0140315molecular_functioniron ion sequestering activity
C1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
C1903981molecular_functionenterobactin binding
C1904373biological_processresponse to kainic acid
C1904440biological_processpositive regulation of iron ion import across plasma membrane
C1904646biological_processcellular response to amyloid-beta
C1905956biological_processpositive regulation of endothelial tube morphogenesis
C1990090biological_processcellular response to nerve growth factor stimulus
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
D0002020molecular_functionprotease binding
D0002376biological_processimmune system process
D0005506molecular_functioniron ion binding
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0006811biological_processmonoatomic ion transport
D0006826biological_processiron ion transport
D0006915biological_processapoptotic process
D0006953biological_processacute-phase response
D0006979biological_processresponse to oxidative stress
D0007614biological_processshort-term memory
D0007616biological_processlong-term memory
D0009410biological_processresponse to xenobiotic stimulus
D0009615biological_processresponse to virus
D0009617biological_processresponse to bacterium
D0009635biological_processresponse to herbicide
D0009636biological_processresponse to toxic substance
D0009637biological_processresponse to blue light
D0009750biological_processresponse to fructose
D0010040biological_processresponse to iron(II) ion
D0010046biological_processresponse to mycotoxin
D0010595biological_processpositive regulation of endothelial cell migration
D0010628biological_processpositive regulation of gene expression
D0015891biological_processsiderophore transport
D0031346biological_processpositive regulation of cell projection organization
D0031410cellular_componentcytoplasmic vesicle
D0031667biological_processresponse to nutrient levels
D0031669biological_processcellular response to nutrient levels
D0032496biological_processresponse to lipopolysaccharide
D0035580cellular_componentspecific granule lumen
D0036094molecular_functionsmall molecule binding
D0036295biological_processcellular response to increased oxygen levels
D0042742biological_processdefense response to bacterium
D0042802molecular_functionidentical protein binding
D0043065biological_processpositive regulation of apoptotic process
D0043525biological_processpositive regulation of neuron apoptotic process
D0045087biological_processinnate immune response
D0060205cellular_componentcytoplasmic vesicle lumen
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0071222biological_processcellular response to lipopolysaccharide
D0071347biological_processcellular response to interleukin-1
D0071354biological_processcellular response to interleukin-6
D0071356biological_processcellular response to tumor necrosis factor
D0071456biological_processcellular response to hypoxia
D0071481biological_processcellular response to X-ray
D0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
D0110090biological_processpositive regulation of hippocampal neuron apoptotic process
D0110091biological_processnegative regulation of hippocampal neuron apoptotic process
D0120162biological_processpositive regulation of cold-induced thermogenesis
D0140315molecular_functioniron ion sequestering activity
D1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
D1903981molecular_functionenterobactin binding
D1904373biological_processresponse to kainic acid
D1904440biological_processpositive regulation of iron ion import across plasma membrane
D1904646biological_processcellular response to amyloid-beta
D1905956biological_processpositive regulation of endothelial tube morphogenesis
D1990090biological_processcellular response to nerve growth factor stimulus
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
E0002020molecular_functionprotease binding
E0002376biological_processimmune system process
E0005506molecular_functioniron ion binding
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0006811biological_processmonoatomic ion transport
E0006826biological_processiron ion transport
E0006915biological_processapoptotic process
E0006953biological_processacute-phase response
E0006979biological_processresponse to oxidative stress
E0007614biological_processshort-term memory
E0007616biological_processlong-term memory
E0009410biological_processresponse to xenobiotic stimulus
E0009615biological_processresponse to virus
E0009617biological_processresponse to bacterium
E0009635biological_processresponse to herbicide
E0009636biological_processresponse to toxic substance
E0009637biological_processresponse to blue light
E0009750biological_processresponse to fructose
E0010040biological_processresponse to iron(II) ion
E0010046biological_processresponse to mycotoxin
E0010595biological_processpositive regulation of endothelial cell migration
E0010628biological_processpositive regulation of gene expression
E0015891biological_processsiderophore transport
E0031346biological_processpositive regulation of cell projection organization
E0031410cellular_componentcytoplasmic vesicle
E0031667biological_processresponse to nutrient levels
E0031669biological_processcellular response to nutrient levels
E0032496biological_processresponse to lipopolysaccharide
E0035580cellular_componentspecific granule lumen
E0036094molecular_functionsmall molecule binding
E0036295biological_processcellular response to increased oxygen levels
E0042742biological_processdefense response to bacterium
E0042802molecular_functionidentical protein binding
E0043065biological_processpositive regulation of apoptotic process
E0043525biological_processpositive regulation of neuron apoptotic process
E0045087biological_processinnate immune response
E0060205cellular_componentcytoplasmic vesicle lumen
E0070062cellular_componentextracellular exosome
E0070301biological_processcellular response to hydrogen peroxide
E0071222biological_processcellular response to lipopolysaccharide
E0071347biological_processcellular response to interleukin-1
E0071354biological_processcellular response to interleukin-6
E0071356biological_processcellular response to tumor necrosis factor
E0071456biological_processcellular response to hypoxia
E0071481biological_processcellular response to X-ray
E0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
E0110090biological_processpositive regulation of hippocampal neuron apoptotic process
E0110091biological_processnegative regulation of hippocampal neuron apoptotic process
E0120162biological_processpositive regulation of cold-induced thermogenesis
E0140315molecular_functioniron ion sequestering activity
E1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
E1903981molecular_functionenterobactin binding
E1904373biological_processresponse to kainic acid
E1904440biological_processpositive regulation of iron ion import across plasma membrane
E1904646biological_processcellular response to amyloid-beta
E1905956biological_processpositive regulation of endothelial tube morphogenesis
E1990090biological_processcellular response to nerve growth factor stimulus
E2000379biological_processpositive regulation of reactive oxygen species metabolic process
F0002020molecular_functionprotease binding
F0002376biological_processimmune system process
F0005506molecular_functioniron ion binding
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0006811biological_processmonoatomic ion transport
F0006826biological_processiron ion transport
F0006915biological_processapoptotic process
F0006953biological_processacute-phase response
F0006979biological_processresponse to oxidative stress
F0007614biological_processshort-term memory
F0007616biological_processlong-term memory
F0009410biological_processresponse to xenobiotic stimulus
F0009615biological_processresponse to virus
F0009617biological_processresponse to bacterium
F0009635biological_processresponse to herbicide
F0009636biological_processresponse to toxic substance
F0009637biological_processresponse to blue light
F0009750biological_processresponse to fructose
F0010040biological_processresponse to iron(II) ion
F0010046biological_processresponse to mycotoxin
F0010595biological_processpositive regulation of endothelial cell migration
F0010628biological_processpositive regulation of gene expression
F0015891biological_processsiderophore transport
F0031346biological_processpositive regulation of cell projection organization
F0031410cellular_componentcytoplasmic vesicle
F0031667biological_processresponse to nutrient levels
F0031669biological_processcellular response to nutrient levels
F0032496biological_processresponse to lipopolysaccharide
F0035580cellular_componentspecific granule lumen
F0036094molecular_functionsmall molecule binding
F0036295biological_processcellular response to increased oxygen levels
F0042742biological_processdefense response to bacterium
F0042802molecular_functionidentical protein binding
F0043065biological_processpositive regulation of apoptotic process
F0043525biological_processpositive regulation of neuron apoptotic process
F0045087biological_processinnate immune response
F0060205cellular_componentcytoplasmic vesicle lumen
F0070062cellular_componentextracellular exosome
F0070301biological_processcellular response to hydrogen peroxide
F0071222biological_processcellular response to lipopolysaccharide
F0071347biological_processcellular response to interleukin-1
F0071354biological_processcellular response to interleukin-6
F0071356biological_processcellular response to tumor necrosis factor
F0071456biological_processcellular response to hypoxia
F0071481biological_processcellular response to X-ray
F0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
F0110090biological_processpositive regulation of hippocampal neuron apoptotic process
F0110091biological_processnegative regulation of hippocampal neuron apoptotic process
F0120162biological_processpositive regulation of cold-induced thermogenesis
F0140315molecular_functioniron ion sequestering activity
F1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
F1903981molecular_functionenterobactin binding
F1904373biological_processresponse to kainic acid
F1904440biological_processpositive regulation of iron ion import across plasma membrane
F1904646biological_processcellular response to amyloid-beta
F1905956biological_processpositive regulation of endothelial tube morphogenesis
F1990090biological_processcellular response to nerve growth factor stimulus
F2000379biological_processpositive regulation of reactive oxygen species metabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues1
Detailsbinding site for residue AM A 201
ChainResidue
A4OL202

site_idAC2
Number of Residues15
Detailsbinding site for residue 4OL A 202
ChainResidue
ALYS125
ATYR132
ALYS134
AAM201
AHOH302
AHOH307
AHOH317
AALA40
AILE41
ATYR52
ASER68
ATRP79
AARG81
ATYR100
ATYR106

site_idAC3
Number of Residues3
Detailsbinding site for residue GOL A 203
ChainResidue
AGLN117
CASN114
CHIS118

site_idAC4
Number of Residues3
Detailsbinding site for residue CL A 204
ChainResidue
ATHR54
ATYR138
AHOH324

site_idAC5
Number of Residues2
Detailsbinding site for residue SO4 A 205
ChainResidue
ALYS59
AGLU60

site_idAC6
Number of Residues1
Detailsbinding site for residue AM B 201
ChainResidue
B4OL202

site_idAC7
Number of Residues16
Detailsbinding site for residue 4OL B 202
ChainResidue
BALA40
BILE41
BTYR52
BSER68
BLEU70
BTRP79
BTYR100
BTYR106
BLYS125
BLYS134
BAM201
BHOH301
BHOH304
BHOH311
BHOH331
BHOH349

site_idAC8
Number of Residues3
Detailsbinding site for residue SO4 B 203
ChainResidue
BASN114
BHIS118
DGLN117

site_idAC9
Number of Residues3
Detailsbinding site for residue CL B 204
ChainResidue
BTHR54
BTYR138
BHOH322

site_idAD1
Number of Residues1
Detailsbinding site for residue AM C 201
ChainResidue
C4OL202

site_idAD2
Number of Residues14
Detailsbinding site for residue 4OL C 202
ChainResidue
CILE41
CTYR52
CSER68
CTRP79
CARG81
CTYR100
CTYR106
CLYS125
CLYS134
CAM201
CHOH307
CHOH311
CHOH314
CHOH325

site_idAD3
Number of Residues5
Detailsbinding site for residue SO4 C 203
ChainResidue
CLYS75
DILE8
DPRO162
DASN164
DHIS165

site_idAD4
Number of Residues3
Detailsbinding site for residue CL C 204
ChainResidue
CTHR54
CTYR138
CHOH319

site_idAD5
Number of Residues1
Detailsbinding site for residue AM D 201
ChainResidue
D4OL202

site_idAD6
Number of Residues15
Detailsbinding site for residue 4OL D 202
ChainResidue
DALA40
DILE41
DTYR52
DSER68
DTRP79
DARG81
DTYR100
DTYR106
DLYS125
DLYS134
DAM201
DHOH302
DHOH311
DHOH327
DHOH329

site_idAD7
Number of Residues4
Detailsbinding site for residue CL D 203
ChainResidue
DTHR54
DARG81
DTYR138
DHOH331

site_idAD8
Number of Residues1
Detailsbinding site for residue AM E 201
ChainResidue
E4OL202

site_idAD9
Number of Residues15
Detailsbinding site for residue 4OL E 202
ChainResidue
ELYS125
ELYS134
EAM201
EHOH301
EHOH302
EHOH309
EHOH310
EALA40
EILE41
ETYR52
ESER68
ETRP79
EARG81
ETYR100
ETYR106

site_idAE1
Number of Residues3
Detailsbinding site for residue CL E 203
ChainResidue
ETHR54
ETYR138
EHOH328

site_idAE2
Number of Residues1
Detailsbinding site for residue AM F 201
ChainResidue
F4OL202

site_idAE3
Number of Residues13
Detailsbinding site for residue 4OL F 202
ChainResidue
FALA40
FILE41
FTYR52
FSER68
FTRP79
FTYR100
FTYR106
FLYS125
FLYS134
FAM201
FHOH302
FHOH311
FHOH321

site_idAE4
Number of Residues4
Detailsbinding site for residue GOL F 203
ChainResidue
BASN116
DASN114
DHOH320
FASN116

site_idAE5
Number of Residues3
Detailsbinding site for residue CL F 204
ChainResidue
FTHR54
FTYR138
FHOH318

Functional Information from PROSITE/UniProt
site_idPS00213
Number of Residues14
DetailsLIPOCALIN Lipocalin signature. NFQdnQFQGKWYVV
ChainResidueDetails
AASN21-VAL34

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBINDING: BINDING => ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U
ChainResidueDetails
ATYR52
BTYR52
CTYR52
DTYR52
ETYR52
FTYR52

site_idSWS_FT_FI2
Number of Residues12
DetailsBINDING: BINDING => ECO:0007744|PDB:3CMP
ChainResidueDetails
ATYR106
ELYS134
FTYR106
FLYS134
ALYS134
BTYR106
BLYS134
CTYR106
CLYS134
DTYR106
DLYS134
ETYR106

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:15642259, ECO:0007744|PDB:1X89, ECO:0007744|PDB:1X8U
ChainResidueDetails
ALYS125
ETYR138
FLYS125
FTYR138
ATYR138
BLYS125
BTYR138
CLYS125
CTYR138
DLYS125
DTYR138
ELYS125

site_idSWS_FT_FI4
Number of Residues6
DetailsMOD_RES: Pyrrolidone carboxylic acid => ECO:0000269|PubMed:7683678
ChainResidueDetails
AGLN1
BGLN1
CGLN1
DGLN1
EGLN1
FGLN1

site_idSWS_FT_FI5
Number of Residues6
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:10684642, ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:7683678, ECO:0007744|PDB:1DFV, ECO:0007744|PDB:1QQS
ChainResidueDetails
AASN65
BASN65
CASN65
DASN65
EASN65
FASN65

234785

PDB entries from 2025-04-16

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