4ZG6
Structural basis for inhibition of human autotaxin by four novel compounds
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003676 | molecular_function | nucleic acid binding |
| A | 0005044 | molecular_function | scavenger receptor activity |
| A | 0006955 | biological_process | immune response |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030247 | molecular_function | polysaccharide binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003676 | molecular_function | nucleic acid binding |
| B | 0005044 | molecular_function | scavenger receptor activity |
| B | 0006955 | biological_process | immune response |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0030247 | molecular_function | polysaccharide binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00524 |
| Number of Residues | 21 |
| Details | SMB_1 Somatomedin B domain (SMB) signature. CrCdnlCksyts.CChDFdelC |
| Chain | Residue | Details |
| A | CYS74-CYS94 | |
| A | CYS118-CYS138 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 88 |
| Details | Domain: {"description":"SMB 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00350","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Region: {"description":"Required for secretion","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Motif: {"description":"Cell attachment site","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26371182","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27754931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KXA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26371182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZGA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"26371182","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27754931","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZGA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5KXA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | Site: {"description":"Essential for catalytic activity","evidences":[{"source":"UniProtKB","id":"Q9R1E6","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"26371182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZG6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZG9","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZGA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
