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4ZDZ

Saccharomyces cerevisiae CYP51 (Lanosterol 14-alpha demethylase) Y140F mutant complexed with fluconazole

Functional Information from GO Data
ChainGOidnamespacecontents
A0004497molecular_functionmonooxygenase activity
A0005506molecular_functioniron ion binding
A0005783cellular_componentendoplasmic reticulum
A0006696biological_processergosterol biosynthetic process
A0008168molecular_functionmethyltransferase activity
A0016020cellular_componentmembrane
A0016126biological_processsterol biosynthetic process
A0016491molecular_functionoxidoreductase activity
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0020037molecular_functionheme binding
A0032259biological_processmethylation
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues23
Detailsbinding site for residue HEM A 601
ChainResidue
APHE113
ALEU383
AARG385
APRO462
APHE463
AGLY464
AHIS468
ACYS470
AILE471
AGLY472
APHE475
APHE140
ATPF602
AHOH855
AHOH896
AHOH910
ALEU147
ALYS151
AGLY315
ATHR318
ATHR322
ALEU374
APRO379

site_idAC2
Number of Residues11
Detailsbinding site for residue TPF A 602
ChainResidue
ATYR126
APHE236
AGLY310
AVAL311
AGLY314
ATHR318
ALEU380
AMET509
AHEM601
AHOH839
AHOH855

Functional Information from PROSITE/UniProt
site_idPS00086
Number of Residues10
DetailsCYTOCHROME_P450 Cytochrome P450 cysteine heme-iron ligand signature. FGgGRHRCIG
ChainResidueDetails
APHE463-GLY472

221051

PDB entries from 2024-06-12

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