4ZDK
Crystal structure of the M. tuberculosis CTP synthase PyrG in complex with UTP, AMP-PCP and oxonorleucine
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003883 | molecular_function | CTP synthase activity |
A | 0004359 | molecular_function | glutaminase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
A | 0006241 | biological_process | CTP biosynthetic process |
A | 0006541 | biological_process | glutamine metabolic process |
A | 0016874 | molecular_function | ligase activity |
A | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
A | 0046872 | molecular_function | metal ion binding |
B | 0003883 | molecular_function | CTP synthase activity |
B | 0004359 | molecular_function | glutaminase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005829 | cellular_component | cytosol |
B | 0005886 | cellular_component | plasma membrane |
B | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
B | 0006241 | biological_process | CTP biosynthetic process |
B | 0006541 | biological_process | glutamine metabolic process |
B | 0016874 | molecular_function | ligase activity |
B | 0019856 | biological_process | pyrimidine nucleobase biosynthetic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0044210 | biological_process | 'de novo' CTP biosynthetic process |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 10 |
Details | binding site for residue ONL A 601 |
Chain | Residue |
A | GLY365 |
A | TYR478 |
A | GLY366 |
A | PHE367 |
A | CYS393 |
A | GLN397 |
A | GLU416 |
A | ARG475 |
A | HIS476 |
A | ARG477 |
site_id | AC2 |
Number of Residues | 16 |
Details | binding site for residue ACP A 602 |
Chain | Residue |
A | SER21 |
A | LEU22 |
A | GLY23 |
A | LYS24 |
A | GLY25 |
A | LEU26 |
A | LYS46 |
A | ASP78 |
A | GLU152 |
A | ARG223 |
A | ASP252 |
A | ALA253 |
A | ILE256 |
A | ILE259 |
A | MG604 |
B | PRO194 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue UTP A 603 |
Chain | Residue |
A | SER20 |
A | GLN120 |
A | ILE122 |
A | ASP159 |
A | ILE160 |
A | GLU161 |
B | LEU198 |
B | LYS199 |
B | THR200 |
B | LYS201 |
B | GLN204 |
site_id | AC4 |
Number of Residues | 4 |
Details | binding site for residue MG A 604 |
Chain | Residue |
A | GLY25 |
A | ASP78 |
A | GLU152 |
A | ACP602 |
site_id | AC5 |
Number of Residues | 14 |
Details | binding site for residue ACP B 602 |
Chain | Residue |
A | PRO194 |
B | SER21 |
B | LEU22 |
B | GLY23 |
B | LYS24 |
B | GLY25 |
B | LEU26 |
B | LYS46 |
B | ASP78 |
B | GLU152 |
B | ARG223 |
B | ALA253 |
B | ILE259 |
B | MG604 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue UTP B 603 |
Chain | Residue |
A | LYS199 |
A | THR200 |
A | LYS201 |
A | GLN204 |
B | SER20 |
B | GLN120 |
B | ILE122 |
B | ASP159 |
B | ILE160 |
B | GLU161 |
site_id | AC7 |
Number of Residues | 4 |
Details | binding site for residue MG B 604 |
Chain | Residue |
B | GLY25 |
B | ASP78 |
B | GLU152 |
B | ACP602 |
site_id | AC8 |
Number of Residues | 16 |
Details | binding site for Di-peptide ONL B 601 and CYS B 393 |
Chain | Residue |
B | GLY365 |
B | GLY366 |
B | LEU392 |
B | LEU394 |
B | GLY395 |
B | LEU396 |
B | GLN397 |
B | GLU416 |
B | ARG475 |
B | HIS476 |
B | ARG477 |
B | TYR478 |
B | THR521 |
B | GLN522 |
B | ALA523 |
B | HIS524 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile; for glutamine hydrolysis => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000269|PubMed:26097035 |
Chain | Residue | Details |
A | CYS393 | |
B | CYS393 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | ACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01227, ECO:0000305|PubMed:26097035 |
Chain | Residue | Details |
A | HIS524 | |
A | GLU526 | |
B | HIS524 | |
B | GLU526 |
site_id | SWS_FT_FI3 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000305|PubMed:26097035 |
Chain | Residue | Details |
A | SER20 | |
A | SER21 | |
A | LYS46 | |
A | ALA253 | |
B | SER20 | |
B | SER21 | |
B | LYS46 | |
B | ALA253 |
site_id | SWS_FT_FI4 |
Number of Residues | 16 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01227 |
Chain | Residue | Details |
A | ASP78 | |
B | GLU152 | |
B | LYS199 | |
B | LYS235 | |
B | GLY366 | |
B | LEU394 | |
B | GLU416 | |
B | ARG477 | |
A | GLU152 | |
A | LYS199 | |
A | LYS235 | |
A | GLY366 | |
A | LEU394 | |
A | GLU416 | |
A | ARG477 | |
B | ASP78 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000250|UniProtKB:P0A7E5, ECO:0000305|PubMed:26097035 |
Chain | Residue | Details |
A | ASP159 | |
B | ASP159 |