4ZDE

Crystal structure of yeast D3,D2-enoyl-CoA isomerase F268A mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004165	molecular_function	delta(3)-delta(2)-enoyl-CoA isomerase activity
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0006629	biological_process	lipid metabolic process
A	0006631	biological_process	fatty acid metabolic process
A	0006635	biological_process	fatty acid beta-oxidation
A	0016853	molecular_function	isomerase activity
B	0004165	molecular_function	delta(3)-delta(2)-enoyl-CoA isomerase activity
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0006629	biological_process	lipid metabolic process
B	0006631	biological_process	fatty acid metabolic process
B	0006635	biological_process	fatty acid beta-oxidation
B	0016853	molecular_function	isomerase activity
C	0004165	molecular_function	delta(3)-delta(2)-enoyl-CoA isomerase activity
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0006629	biological_process	lipid metabolic process
C	0006631	biological_process	fatty acid metabolic process
C	0006635	biological_process	fatty acid beta-oxidation
C	0016853	molecular_function	isomerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue GOL A 301

Chain	Residue
A	ALA70
A	PHE97
A	ARG100
A	GLY125
A	LEU126
A	LEU155
A	GLU158
A	HOH403

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 A 302

Chain	Residue
A	PRO202
A	SER203
A	SER204
A	ARG64

---

site_id	AC3
Number of Residues	6
Details	binding site for residue SO4 A 303

Chain	Residue
A	SER62
A	GLY63
A	ALA206
A	GLU207
A	HOH419
A	HOH467

---

site_id	AC4
Number of Residues	5
Details	binding site for residue SO4 A 304

Chain	Residue
A	TYR225
A	PRO227
A	HOH452
B	LYS257
B	ASP261

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 305

Chain	Residue
A	LYS257
A	TYR258
C	TYR225

---

site_id	AC6
Number of Residues	3
Details	binding site for residue SO4 A 306

Chain	Residue
A	GLU9
A	ILE25
A	ASN26

---

site_id	AC7
Number of Residues	9
Details	binding site for residue GOL B 301

Chain	Residue
B	ALA70
B	PHE97
B	ARG100
B	GLY125
B	LEU126
B	PHE150
B	LEU155
B	GLU158
B	HOH456

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 302

Chain	Residue
B	ARG64
B	LYS143
B	PRO202
B	SER203
B	SER204

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 B 303

Chain	Residue
B	SER62
B	GLY63
B	ALA206
B	GLU207
B	SO4304
B	HOH405
B	HOH411

---

site_id	AD1
Number of Residues	3
Details	binding site for residue SO4 B 304

Chain	Residue
B	SO4303
B	HOH422
B	HOH446

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 305

Chain	Residue
B	GLU9
B	ILE25
B	ASN26

---

site_id	AD3
Number of Residues	8
Details	binding site for residue GOL C 301

Chain	Residue
C	GLY69
C	ALA70
C	ARG100
C	GLY125
C	LEU126
C	LEU155
C	GLU158
C	HOH425

---

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 C 302

Chain	Residue
C	ARG64
C	LYS143
C	PRO202
C	SER203
C	SER204

---

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 C 303

Chain	Residue
C	GLY63
C	SER204
C	ALA206
C	GLU207

---

site_id	AD6
Number of Residues	3
Details	binding site for residue SO4 C 304

Chain	Residue
C	SER12
C	HIS23
C	ILE25

---

site_id	AD7
Number of Residues	5
Details	binding site for residue SO4 C 305

Chain	Residue
B	TYR225
B	PRO227
C	LYS257
C	TYR258
C	ASP261

---

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 C 306

Chain	Residue
C	GLU9
C	ASN26

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"26527136","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26527136","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZDC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	3
Details	Binding site: {"evidences":[{"source":"PubMed","id":"26527136","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4ZDC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	4
Details	M-CSA 499

Chain	Residue	Details
A	ALA70	electrostatic stabiliser
A	ASN101	electrostatic stabiliser, modifies pKa
A	LEU126	electrostatic stabiliser
A	GLU158	proton acceptor, proton donor

---

site_id	MCSA2
Number of Residues	4
Details	M-CSA 499

Chain	Residue	Details
B	ALA70	electrostatic stabiliser
B	ASN101	electrostatic stabiliser, modifies pKa
B	LEU126	electrostatic stabiliser
B	GLU158	proton acceptor, proton donor

---

site_id	MCSA3
Number of Residues	4
Details	M-CSA 499

Chain	Residue	Details
C	ALA70	electrostatic stabiliser
C	ASN101	electrostatic stabiliser, modifies pKa
C	LEU126	electrostatic stabiliser
C	GLU158	proton acceptor, proton donor

---