Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4ZCV

Structure of calcium-bound regulatory domain of the human ATP-Mg/Pi carrier in the P212121 form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding
B	0005509	molecular_function	calcium ion binding
C	0005509	molecular_function	calcium ion binding
D	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 1001

Chain	Residue
A	ASP32
A	ASN34
A	ASP36
A	VAL38
A	GLU43

site_id	AC2
Number of Residues	5
Details	binding site for residue CA A 1002

Chain	Residue
A	GLU79
A	ASP68
A	ASN70
A	ASP72
A	LYS74

site_id	AC3
Number of Residues	6
Details	binding site for residue CA A 1003

Chain	Residue
A	ASN101
A	ASP103
A	LYS105
A	GLU107
A	GLU110
A	HOH1112

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 A 1004

Chain	Residue
A	PRO54
A	TYR150
A	ASN154

site_id	AC5
Number of Residues	7
Details	binding site for residue SO4 A 1005

Chain	Residue
A	PRO21
A	THR22
A	ARG23
A	TYR24
A	GLU25
A	THR26
C	ASN50

site_id	AC6
Number of Residues	4
Details	binding site for residue GOL A 1006

Chain	Residue
A	GLY56
A	GLN57
A	ASP58
A	HOH1101

site_id	AC7
Number of Residues	6
Details	binding site for residue SO4 A 1007

Chain	Residue
A	VAL136
A	HOH1102
C	PRO54
C	LEU55
C	TYR150
C	ASN154

site_id	AC8
Number of Residues	6
Details	binding site for residue CA B 1001

Chain	Residue
B	ASP32
B	ASN34
B	ASP36
B	VAL38
B	GLU43
B	HOH1102

site_id	AC9
Number of Residues	6
Details	binding site for residue CA B 1002

Chain	Residue
B	ASP68
B	ASN70
B	ASP72
B	LYS74
B	GLU79
B	HOH1106

site_id	AD1
Number of Residues	6
Details	binding site for residue CA B 1003

Chain	Residue
B	ASP99
B	ASN101
B	ASP103
B	LYS105
B	GLU110
B	HOH1104

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 B 1004

Chain	Residue
B	THR22
B	ARG23
B	TYR24
B	GLU25
B	THR26
D	ASN50

site_id	AD3
Number of Residues	4
Details	binding site for residue GOL B 1005

Chain	Residue
B	GLY56
B	GLN57
B	ASP58
B	ALA59

site_id	AD4
Number of Residues	6
Details	binding site for residue CA C 1001

Chain	Residue
C	ASP32
C	ASN34
C	ASP36
C	VAL38
C	GLU43
C	HOH1101

site_id	AD5
Number of Residues	6
Details	binding site for residue CA C 1002

Chain	Residue
C	ASP68
C	ASN70
C	ASP72
C	LYS74
C	GLU79
C	HOH1105

site_id	AD6
Number of Residues	5
Details	binding site for residue CA C 1003

Chain	Residue
C	ASP99
C	ASN101
C	ASP103
C	LYS105
C	GLU110

site_id	AD7
Number of Residues	5
Details	binding site for residue CA C 1004

Chain	Residue
C	ASP135
C	ASP137
C	THR139
C	THR141
C	GLU146

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 C 1005

Chain	Residue
A	ARG33
C	ARG23
C	TYR24
C	GLU25
C	THR26

site_id	AD9
Number of Residues	6
Details	binding site for residue GOL C 1006

Chain	Residue
C	GLY56
C	GLN57
C	ASP58
C	ALA59
C	HOH1102
C	HOH1103

site_id	AE1
Number of Residues	6
Details	binding site for residue CA D 1001

Chain	Residue
D	ASP36
D	VAL38
D	ASP40
D	GLU43
D	ASP32
D	ASN34

site_id	AE2
Number of Residues	5
Details	binding site for residue CA D 1002

Chain	Residue
D	ASP68
D	ASN70
D	ASP72
D	LYS74
D	GLU79

site_id	AE3
Number of Residues	6
Details	binding site for residue CA D 1003

Chain	Residue
D	ASP99
D	ASN101
D	ASP103
D	LYS105
D	GLU110
D	HOH1102

site_id	AE4
Number of Residues	3
Details	binding site for residue SO4 D 1004

Chain	Residue
D	ARG23
D	TYR24
D	THR26

Functional Information from PROSITE/UniProt

site_id	PS00018
Number of Residues	13
Details	EF_HAND_1 EF-hand calcium-binding domain. DRNGDGVVDigEL

Chain	Residue	Details
A	ASP32-LEU44
A	ASP68-PHE80
A	ASP99-ILE111

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:24332718, ECO:0000269\|PubMed:26164100, ECO:0007744\|PDB:4N5X, ECO:0007744\|PDB:4ZCU, ECO:0007744\|PDB:4ZCV

Chain	Residue	Details
A	ASP32
A	ASP103
A	LYS105
A	GLU110
B	ASP32
B	ASN34
B	ASP36
B	ASP68
B	ASN70
B	ASP72
B	LYS74
A	ASN34
B	ASP99
B	ASN101
B	ASP103
B	LYS105
B	GLU110
C	ASP32
C	ASN34
C	ASP36
C	ASP68
C	ASN70
A	ASP36
C	ASP72
C	LYS74
C	ASP99
C	ASN101
C	ASP103
C	LYS105
C	GLU110
D	ASP32
D	ASN34
D	ASP36
A	ASP68
D	ASP68
D	ASN70
D	ASP72
D	LYS74
D	ASP99
D	ASN101
D	ASP103
D	LYS105
D	GLU110
A	ASN70
A	ASP72
A	LYS74
A	ASP99
A	ASN101

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000269\|PubMed:24332718, ECO:0000269\|PubMed:26164100, ECO:0007744\|PDB:4N5X, ECO:0007744\|PDB:4ZCU, ECO:0007744\|PDB:4ZCV

Chain	Residue	Details
A	VAL38
B	THR139
B	THR141
B	GLU146
C	VAL38
C	ASP135
C	ASP137
C	THR139
C	THR141
C	GLU146
D	VAL38
A	ASP135
D	ASP135
D	ASP137
D	THR139
D	THR141
D	GLU146
A	ASP137
A	THR139
A	THR141
A	GLU146
B	VAL38
B	ASP135
B	ASP137

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:24332718, ECO:0000269\|PubMed:26164100, ECO:0007744\|PDB:4ZCU, ECO:0007744\|PDB:4ZCV

Chain	Residue	Details
A	GLU43
B	GLU43
C	GLU43
D	GLU43

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00448, ECO:0000269\|PubMed:24332718, ECO:0000269\|PubMed:26164100, ECO:0007744\|PDB:4N5X, ECO:0007744\|PDB:4ZCV

Chain	Residue	Details
A	GLU79
B	GLU79
C	GLU79
D	GLU79

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)