4ZBF

Mcl-1 complexed with small molecules

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0042981	biological_process	regulation of apoptotic process
B	0042981	biological_process	regulation of apoptotic process
C	0042981	biological_process	regulation of apoptotic process
D	0042981	biological_process	regulation of apoptotic process
E	0042981	biological_process	regulation of apoptotic process
F	0042981	biological_process	regulation of apoptotic process
G	0042981	biological_process	regulation of apoptotic process
H	0042981	biological_process	regulation of apoptotic process
I	0042981	biological_process	regulation of apoptotic process
J	0042981	biological_process	regulation of apoptotic process
K	0042981	biological_process	regulation of apoptotic process
L	0042981	biological_process	regulation of apoptotic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 4M7 A 400

Chain	Residue
A	PHE228
A	ILE294
A	MET231
A	LEU235
A	VAL253
A	ARG263
A	THR266
A	LEU267
A	PHE270
A	GLY271

---

site_id	AC2
Number of Residues	8
Details	binding site for residue 4M7 B 400

Chain	Residue
B	PHE228
B	PHE254
B	ARG263
B	THR266
B	LEU267
B	PHE270
B	ILE294
B	HOH519

---

site_id	AC3
Number of Residues	8
Details	binding site for residue 4M7 C 400

Chain	Residue
C	PHE228
C	LEU235
C	MET250
C	PHE254
C	ARG263
C	LEU267
C	PHE270
C	ILE294

---

site_id	AC4
Number of Residues	8
Details	binding site for residue 4M7 D 400

Chain	Residue
D	MET250
D	VAL253
D	ARG263
D	THR266
D	LEU267
D	PHE270
D	GLY271
D	HOH504

---

site_id	AC5
Number of Residues	11
Details	binding site for residue 4M7 E 400

Chain	Residue
E	ALA227
E	MET231
E	LEU235
E	MET250
E	VAL253
E	ARG263
E	THR266
E	LEU267
E	PHE270
E	GLY271
E	ILE294

---

site_id	AC6
Number of Residues	8
Details	binding site for residue 4M7 F 400

Chain	Residue
F	LEU235
F	MET250
F	VAL253
F	ARG263
F	THR266
F	LEU267
F	PHE270
F	GLY271

---

site_id	AC7
Number of Residues	7
Details	binding site for residue 4M7 G 400

Chain	Residue
G	ALA227
G	LEU235
G	VAL253
G	PHE254
G	ARG263
G	LEU267
G	PHE270

---

site_id	AC8
Number of Residues	11
Details	binding site for residue 4M7 H 400

Chain	Residue
H	ALA227
H	PHE228
H	MET250
H	VAL253
H	PHE254
H	ARG263
H	THR266
H	LEU267
H	PHE270
H	GLY271
H	ILE294

---

site_id	AC9
Number of Residues	7
Details	binding site for residue 4M7 I 400

Chain	Residue
I	ALA227
I	LEU235
I	ARG263
I	THR266
I	LEU267
I	PHE270
I	HOH505

---

site_id	AD1
Number of Residues	10
Details	binding site for residue 4M7 J 400

Chain	Residue
C	GLU225
J	ALA227
J	MET231
J	LEU235
J	MET250
J	VAL253
J	ARG263
J	THR266
J	LEU267
J	PHE270

---

site_id	AD2
Number of Residues	8
Details	binding site for residue 4M7 K 400

Chain	Residue
K	PHE228
K	MET250
K	VAL253
K	ARG263
K	THR266
K	LEU267
K	PHE270
K	GLY271

---

site_id	AD3
Number of Residues	9
Details	binding site for residue 4M7 L 400

Chain	Residue
L	ARG263
L	THR266
L	LEU267
L	PHE270
L	GLY271
L	ILE294
L	MET250
L	VAL253
L	PHE254

---

Functional Information from PROSITE/UniProt

site_id	PS01080
Number of Residues	20
Details	BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. VFsDGvtNWGRIVTLIsFGA

Chain	Residue	Details
A	VAL253-ALA272

---

site_id	PS01258
Number of Residues	12
Details	BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WLvkqRGWDgFV

Chain	Residue	Details
A	TRP305-VAL316

---

site_id	PS01259
Number of Residues	15
Details	BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. AletLRrVGDGVQRN

Chain	Residue	Details
A	ALA209-ASN223

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	36
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Chain	Residue	Details
A	LYS194
D	LYS194
D	LYS197
E	LYS194
E	LYS197
F	LYS194
F	LYS197
G	LYS194
G	LYS197
H	LYS194
H	LYS197
I	LYS194
I	LYS197
J	LYS194
A	LYS197
J	LYS197
K	LYS194
K	LYS197
L	LYS194
L	LYS197
B	LYS194
B	LYS197
C	LYS194
C	LYS197

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