Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Z9M

Crystal structure of human sarcomeric mitochondrial creatine kinase

Replaces: 2GL6

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004111	molecular_function	creatine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006936	biological_process	muscle contraction
A	0016301	molecular_function	kinase activity
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0046314	biological_process	phosphocreatine biosynthetic process
B	0003824	molecular_function	catalytic activity
B	0004111	molecular_function	creatine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006936	biological_process	muscle contraction
B	0016301	molecular_function	kinase activity
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0046314	biological_process	phosphocreatine biosynthetic process
C	0003824	molecular_function	catalytic activity
C	0004111	molecular_function	creatine kinase activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006936	biological_process	muscle contraction
C	0016301	molecular_function	kinase activity
C	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
C	0046314	biological_process	phosphocreatine biosynthetic process
D	0003824	molecular_function	catalytic activity
D	0004111	molecular_function	creatine kinase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0006936	biological_process	muscle contraction
D	0016301	molecular_function	kinase activity
D	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
D	0046314	biological_process	phosphocreatine biosynthetic process
E	0003824	molecular_function	catalytic activity
E	0004111	molecular_function	creatine kinase activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0006936	biological_process	muscle contraction
E	0016301	molecular_function	kinase activity
E	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
E	0046314	biological_process	phosphocreatine biosynthetic process
F	0003824	molecular_function	catalytic activity
F	0004111	molecular_function	creatine kinase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0006936	biological_process	muscle contraction
F	0016301	molecular_function	kinase activity
F	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
F	0046314	biological_process	phosphocreatine biosynthetic process
G	0003824	molecular_function	catalytic activity
G	0004111	molecular_function	creatine kinase activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006936	biological_process	muscle contraction
G	0016301	molecular_function	kinase activity
G	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
G	0046314	biological_process	phosphocreatine biosynthetic process
H	0003824	molecular_function	catalytic activity
H	0004111	molecular_function	creatine kinase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006936	biological_process	muscle contraction
H	0016301	molecular_function	kinase activity
H	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
H	0046314	biological_process	phosphocreatine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue ADP A 501

Chain	Residue
A	SER162
A	HIS330
A	ARG354
A	THR356
A	GLY358
A	VAL359
A	ASP369
A	HOH614
A	HOH651
A	ARG164
A	ARG166
A	HIS225
A	TRP262
A	MET274
A	ARG326
A	GLY328
A	VAL329

site_id	AC2
Number of Residues	10
Details	binding site for residue ADP B 501

Chain	Residue
B	SER162
B	ARG164
B	ARG166
B	HIS225
B	TRP262
B	MET274
B	ARG326
B	VAL329
B	HIS330
B	HOH643

site_id	AC3
Number of Residues	18
Details	binding site for residue ADP C 501

Chain	Residue
C	SER162
C	ARG164
C	ARG166
C	HIS225
C	PHE228
C	MET274
C	ARG326
C	VAL329
C	HIS330
C	ARG354
C	THR356
C	GLY357
C	GLY358
C	VAL359
C	ASP369
C	HOH611
C	HOH661
C	HOH668

site_id	AC4
Number of Residues	14
Details	binding site for residue ADP D 501

Chain	Residue
D	SER162
D	ARG164
D	ARG166
D	MET274
D	ARG326
D	HIS330
D	ARG354
D	THR356
D	GLY357
D	GLY358
D	VAL359
D	ASP369
D	HOH648
D	HOH674

site_id	AC5
Number of Residues	23
Details	binding site for residue ADP E 501

Chain	Residue
E	SER162
E	ARG164
E	ARG166
E	HIS225
E	TRP262
E	ARG270
E	MET274
E	ARG326
E	VAL329
E	HIS330
E	ARG354
E	THR356
E	GLY357
E	GLY358
E	VAL359
E	ASP369
E	HOH607
E	HOH628
E	HOH659
E	HOH663
E	HOH668
E	HOH678
E	HOH710

site_id	AC6
Number of Residues	22
Details	binding site for residue ADP F 501

Chain	Residue
F	HOH621
F	HOH653
F	HOH658
F	HOH661
F	HOH680
F	SER162
F	ARG164
F	ARG166
F	HIS225
F	TRP262
F	MET274
F	ARG326
F	GLY328
F	VAL329
F	HIS330
F	ARG354
F	THR356
F	GLY357
F	GLY358
F	VAL359
F	ASP369
F	HOH603

site_id	AC7
Number of Residues	15
Details	binding site for residue ADP G 501

Chain	Residue
G	SER162
G	ARG164
G	ARG166
G	HIS225
G	ARG270
G	MET274
G	ARG326
G	GLY328
G	VAL329
G	HIS330
G	ARG354
G	GLY357
G	GLY358
G	VAL359
G	ASP369

site_id	AC8
Number of Residues	19
Details	binding site for residue ADP H 501

Chain	Residue
H	SER162
H	ARG164
H	ARG166
H	HIS225
H	TRP262
H	ARG270
H	MET274
H	ARG326
H	GLY328
H	VAL329
H	HIS330
H	ARG354
H	THR356
H	GLY357
H	GLY358
H	VAL359
H	ASP369
H	HOH607
H	HOH631

Functional Information from PROSITE/UniProt

site_id	PS00112
Number of Residues	7
Details	PHOSPHAGEN_KINASE Phosphagen kinase active site signature. CP.SNLGT

Chain	Residue	Details
A	CYS317-THR323

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	40
Details	BINDING:

Chain	Residue	Details
A	SER162
B	ASP369
C	SER162
C	HIS225
C	ARG326
C	ARG354
C	ASP369
D	SER162
D	HIS225
D	ARG326
D	ARG354
A	HIS225
D	ASP369
E	SER162
E	HIS225
E	ARG326
E	ARG354
E	ASP369
F	SER162
F	HIS225
F	ARG326
F	ARG354
A	ARG326
F	ASP369
G	SER162
G	HIS225
G	ARG326
G	ARG354
G	ASP369
H	SER162
H	HIS225
H	ARG326
H	ARG354
A	ARG354
H	ASP369
A	ASP369
B	SER162
B	HIS225
B	ARG326
B	ARG354

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU00843

Chain	Residue	Details
A	ARG270
B	ARG270
C	ARG270
D	ARG270
E	ARG270
F	ARG270
G	ARG270
H	ARG270

site_id	SWS_FT_FI3
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000250\|UniProtKB:P09605

Chain	Residue	Details
A	TYR255
B	TYR255
C	TYR255
D	TYR255
E	TYR255
F	TYR255
G	TYR255
H	TYR255

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphothreonine => ECO:0000250\|UniProtKB:Q6P8J7

Chain	Residue	Details
A	THR356
B	THR356
C	THR356
D	THR356
E	THR356
F	THR356
G	THR356
H	THR356

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)