Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

4Z91

ELIC cocrystallized with isofluorane in a desensitized state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0006811	biological_process	monoatomic ion transport
A	0007165	biological_process	signal transduction
A	0016020	cellular_component	membrane
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042391	biological_process	regulation of membrane potential
A	0042802	molecular_function	identical protein binding
A	0043005	cellular_component	neuron projection
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0006811	biological_process	monoatomic ion transport
B	0007165	biological_process	signal transduction
B	0016020	cellular_component	membrane
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042391	biological_process	regulation of membrane potential
B	0042802	molecular_function	identical protein binding
B	0043005	cellular_component	neuron projection
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0006811	biological_process	monoatomic ion transport
C	0007165	biological_process	signal transduction
C	0016020	cellular_component	membrane
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042391	biological_process	regulation of membrane potential
C	0042802	molecular_function	identical protein binding
C	0043005	cellular_component	neuron projection
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0006811	biological_process	monoatomic ion transport
D	0007165	biological_process	signal transduction
D	0016020	cellular_component	membrane
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042391	biological_process	regulation of membrane potential
D	0042802	molecular_function	identical protein binding
D	0043005	cellular_component	neuron projection
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0006811	biological_process	monoatomic ion transport
E	0007165	biological_process	signal transduction
E	0016020	cellular_component	membrane
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042391	biological_process	regulation of membrane potential
E	0042802	molecular_function	identical protein binding
E	0043005	cellular_component	neuron projection
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005216	molecular_function	monoatomic ion channel activity
F	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
F	0006811	biological_process	monoatomic ion transport
F	0007165	biological_process	signal transduction
F	0016020	cellular_component	membrane
F	0034220	biological_process	monoatomic ion transmembrane transport
F	0042391	biological_process	regulation of membrane potential
F	0042802	molecular_function	identical protein binding
F	0043005	cellular_component	neuron projection
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005216	molecular_function	monoatomic ion channel activity
G	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
G	0006811	biological_process	monoatomic ion transport
G	0007165	biological_process	signal transduction
G	0016020	cellular_component	membrane
G	0034220	biological_process	monoatomic ion transmembrane transport
G	0042391	biological_process	regulation of membrane potential
G	0042802	molecular_function	identical protein binding
G	0043005	cellular_component	neuron projection
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005216	molecular_function	monoatomic ion channel activity
H	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
H	0006811	biological_process	monoatomic ion transport
H	0007165	biological_process	signal transduction
H	0016020	cellular_component	membrane
H	0034220	biological_process	monoatomic ion transmembrane transport
H	0042391	biological_process	regulation of membrane potential
H	0042802	molecular_function	identical protein binding
H	0043005	cellular_component	neuron projection
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005216	molecular_function	monoatomic ion channel activity
I	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
I	0006811	biological_process	monoatomic ion transport
I	0007165	biological_process	signal transduction
I	0016020	cellular_component	membrane
I	0034220	biological_process	monoatomic ion transmembrane transport
I	0042391	biological_process	regulation of membrane potential
I	0042802	molecular_function	identical protein binding
I	0043005	cellular_component	neuron projection
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005216	molecular_function	monoatomic ion channel activity
J	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
J	0006811	biological_process	monoatomic ion transport
J	0007165	biological_process	signal transduction
J	0016020	cellular_component	membrane
J	0034220	biological_process	monoatomic ion transmembrane transport
J	0042391	biological_process	regulation of membrane potential
J	0042802	molecular_function	identical protein binding
J	0043005	cellular_component	neuron projection

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 4LE A 401

Chain	Residue
A	LEU240
A	ALA244
C	LEU240
D	LEU240
E	LEU240

site_id	AC2
Number of Residues	4
Details	binding site for residue MES A 402

Chain	Residue
A	SER202
A	TRP206
B	THR259
B	GLN264

site_id	AC3
Number of Residues	1
Details	binding site for residue 4LJ A 404

Chain	Residue
A	PHE78

site_id	AC4
Number of Residues	3
Details	binding site for residue MES B 401

Chain	Residue
B	TRP206
C	THR259
C	GLN264

site_id	AC5
Number of Residues	1
Details	binding site for residue 4LJ B 403

Chain	Residue
B	PHE78

site_id	AC6
Number of Residues	3
Details	binding site for residue MES C 401

Chain	Residue
C	TRP206
D	THR259
D	GLN264

site_id	AC7
Number of Residues	1
Details	binding site for residue 4LJ C 403

Chain	Residue
C	PHE78

site_id	AC8
Number of Residues	2
Details	binding site for residue MES D 401

Chain	Residue
D	TRP206
E	GLN264

site_id	AC9
Number of Residues	2
Details	binding site for residue 4LJ D 402

Chain	Residue
D	GLU77
D	PHE78

site_id	AD1
Number of Residues	8
Details	binding site for residue 4LE E 401

Chain	Residue
A	THR237
B	THR237
B	LEU240
C	THR237
C	LEU240
D	THR237
E	THR237
E	LEU240

site_id	AD2
Number of Residues	3
Details	binding site for residue MES E 402

Chain	Residue
A	THR259
A	GLN264
E	TRP206

site_id	AD3
Number of Residues	2
Details	binding site for residue 4LJ E 403

Chain	Residue
E	PHE78
E	PRO85

site_id	AD4
Number of Residues	1
Details	binding site for residue 4LJ E 404

Chain	Residue
E	LEU178

site_id	AD5
Number of Residues	6
Details	binding site for residue 4LE F 401

Chain	Residue
F	THR237
G	THR237
H	THR237
I	THR237
I	LEU240
J	THR237

site_id	AD6
Number of Residues	3
Details	binding site for residue MES F 402

Chain	Residue
F	TRP206
G	THR259
G	GLN264

site_id	AD7
Number of Residues	1
Details	binding site for residue 4LJ F 403

Chain	Residue
F	PHE19

site_id	AD8
Number of Residues	2
Details	binding site for residue 4LJ F 404

Chain	Residue
F	LEU178
J	ARG91

site_id	AD9
Number of Residues	3
Details	binding site for residue MES G 401

Chain	Residue
G	TRP206
H	THR259
H	GLN264

site_id	AE1
Number of Residues	1
Details	binding site for residue 4LJ G 403

Chain	Residue
G	PHE78

site_id	AE2
Number of Residues	3
Details	binding site for residue MES H 401

Chain	Residue
H	TRP206
I	THR259
I	GLN264

site_id	AE3
Number of Residues	1
Details	binding site for residue 4LJ H 402

Chain	Residue
H	ARG91

site_id	AE4
Number of Residues	2
Details	binding site for residue 4LJ H 403

Chain	Residue
H	GLU77
H	PHE78

site_id	AE5
Number of Residues	3
Details	binding site for residue MES I 401

Chain	Residue
I	TRP206
J	THR259
J	GLN264

site_id	AE6
Number of Residues	1
Details	binding site for residue 4LJ I 402

Chain	Residue
I	PHE78

site_id	AE7
Number of Residues	7
Details	binding site for residue 4LE J 401

Chain	Residue
F	LEU240
F	ALA244
G	LEU240
H	ALA244
I	LEU240
J	LEU240
J	ALA244

site_id	AE8
Number of Residues	3
Details	binding site for residue MES J 402

Chain	Residue
F	THR259
F	GLN264
J	TRP206

site_id	AE9
Number of Residues	2
Details	binding site for residue 4LJ J 403

Chain	Residue
F	PHE78
J	ASN89

site_id	AF1
Number of Residues	1
Details	binding site for residue 4LJ J 404

Chain	Residue
I	ASN89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)