4Z7F

Crystal structure of FolT bound with folic acid

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016020	cellular_component	membrane
A	0022857	molecular_function	transmembrane transporter activity
A	0055085	biological_process	transmembrane transport
B	0016020	cellular_component	membrane
B	0022857	molecular_function	transmembrane transporter activity
B	0055085	biological_process	transmembrane transport
C	0016020	cellular_component	membrane
C	0022857	molecular_function	transmembrane transporter activity
C	0055085	biological_process	transmembrane transport
D	0016020	cellular_component	membrane
D	0022857	molecular_function	transmembrane transporter activity
D	0055085	biological_process	transmembrane transport
E	0016020	cellular_component	membrane
E	0022857	molecular_function	transmembrane transporter activity
E	0055085	biological_process	transmembrane transport
F	0016020	cellular_component	membrane
F	0022857	molecular_function	transmembrane transporter activity
F	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue FOL A 201

Chain	Residue
A	THR32
A	PHE77
A	PHE80
A	THR81
A	ASN117
A	THR121
A	ARG142
A	LYS145
A	LEU35
A	LYS36
A	SER38
A	ASP64
A	MET68
A	ALA74
A	GLY75
A	TYR76

---

site_id	AC2
Number of Residues	14
Details	binding site for residue FOL B 201

Chain	Residue
B	LEU35
B	LYS36
B	ASP64
B	MET68
B	ALA74
B	GLY75
B	TYR76
B	PHE77
B	PHE80
B	THR81
B	ASN117
B	THR121
B	ARG142
B	LYS145

---

site_id	AC3
Number of Residues	14
Details	binding site for residue FOL C 201

Chain	Residue
C	ARG26
C	LYS36
C	ASP64
C	ALA74
C	GLY75
C	TYR76
C	PHE77
C	PHE80
C	THR81
C	ASN117
C	THR121
C	LEU125
C	ARG142
C	LYS145

---

site_id	AC4
Number of Residues	11
Details	binding site for residue FOL D 201

Chain	Residue
D	ARG26
D	THR33
D	LEU35
D	LYS36
D	SER38
D	ASP64
D	MET68
D	PHE80
D	ASN117
D	THR121
D	LYS145

---

site_id	AC5
Number of Residues	11
Details	binding site for residue FOL E 201

Chain	Residue
E	THR32
E	LEU35
E	LYS36
E	MET68
E	ALA74
E	GLY75
E	TYR76
E	PHE77
E	PHE80
E	ASN117
E	THR121

---

site_id	AC6
Number of Residues	11
Details	binding site for residue FOL F 201

Chain	Residue
F	PHE34
F	LEU35
F	LYS36
F	SER38
F	MET68
F	LYS73
F	ALA74
F	PHE80
F	ASN117
F	THR121
F	ARG142

---

site_id	AC7
Number of Residues	7
Details	binding site for Ligand PRO E 43 bound to THR E 40

Chain	Residue
E	THR40
E	PHE41
E	ILE42
E	GLU44
E	SER45
E	LEU46
E	ILE47

---

site_id	AC8
Number of Residues	11
Details	binding site for Di-peptide MET B 14 and PHE B 51

Chain	Residue
B	SER10
B	ILE11
B	ALA12
B	LEU13
B	GLY15
B	VAL16
B	LEU17
B	ILE18
B	ILE47
B	ILE50
B	GLY52

---

site_id	AC9
Number of Residues	6
Details	binding site for Di-peptide TYR B 30 and LYS B 36

Chain	Residue
B	LYS145
B	FOL201
B	ALA29
B	GLU31
B	LEU35
B	ILE37

---

site_id	AD1
Number of Residues	6
Details	binding site for Di-peptide TYR B 30 and LYS B 36

Chain	Residue
B	ALA29
B	GLU31
B	LEU35
B	ILE37
B	LYS145
B	FOL201

---

site_id	AD2
Number of Residues	12
Details	binding site for Di-peptide MET B 49 and MET B 100

Chain	Residue
B	SER45
B	LEU46
B	ILE47
B	GLY48
B	ILE50
B	TYR95
B	TYR96
B	LYS98
B	GLU99
B	THR101
B	LEU160
B	GLY161

---

site_id	AD3
Number of Residues	16
Details	binding site for Di-peptide LEU E 17 and ILE E 47

Chain	Residue
E	LEU13
E	MET14
E	GLY15
E	VAL16
E	ILE18
E	ALA19
E	VAL20
E	VAL21
E	PRO43
E	GLU44
E	SER45
E	LEU46
E	GLY48
E	MET49
E	ILE50
E	PHE51

---

site_id	AD4
Number of Residues	12
Details	binding site for Di-peptide ILE E 42 and LEU E 160

Chain	Residue
E	THR40
E	PHE41
E	PRO43
E	GLU44
E	SER45
E	LEU46
E	MET49
E	ALA156
E	THR157
E	TYR158
E	TYR159
E	GLY161

---

site_id	AD5
Number of Residues	10
Details	binding site for Di-peptide GLY E 79 and TRP E 124

Chain	Residue
E	PHE77
E	PRO78
E	PHE80
E	THR81
E	LEU82
E	ASN83
E	LEU120
E	PRO122
E	LEU123
E	LEU125

---

site_id	AD6
Number of Residues	10
Details	binding site for Di-peptide GLY E 79 and TRP E 124

Chain	Residue
E	PHE77
E	PRO78
E	PHE80
E	THR81
E	LEU82
E	ASN83
E	LEU120
E	PRO122
E	LEU123
E	LEU125

---

site_id	AD7
Number of Residues	10
Details	binding site for Di-peptide GLY E 79 and TRP E 124

Chain	Residue
E	PHE77
E	PRO78
E	PHE80
E	THR81
E	LEU82
E	ASN83
E	LEU120
E	PRO122
E	LEU123
E	LEU125

---

site_id	AD8
Number of Residues	13
Details	binding site for Di-peptide MET F 14 and PHE F 51

Chain	Residue
F	SER10
F	ALA12
F	LEU13
F	GLY15
F	VAL16
F	LEU17
F	ILE18
F	ILE47
F	GLY48
F	ILE50
F	GLY52
F	TRP55
F	ALA56

---