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4Z72

Crystal structure of inorganic pyrophosphatase from Mycobacterium tuberculosis in complex with two phosphate ions

Functional Information from GO Data
ChainGOidnamespacecontents
A0000287molecular_functionmagnesium ion binding
A0004427molecular_functioninorganic diphosphate phosphatase activity
A0005576cellular_componentextracellular region
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006796biological_processphosphate-containing compound metabolic process
A0016787molecular_functionhydrolase activity
A0044228cellular_componenthost cell surface
A0046872molecular_functionmetal ion binding
Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue PO4 A 201
ChainResidue
ALYS16
AHOH306
AHOH315
ATYR42
AASP89
ALYS91
ATYR126
ALYS127
APO4202
AHOH303
AHOH305

site_idAC2
Number of Residues8
Detailsbinding site for residue PO4 A 202
ChainResidue
ALYS16
AARG30
AGLU85
ALYS127
ALYS133
APO4201
AHOH321
AHOH324

site_idAC3
Number of Residues5
Detailsbinding site for residue CA A 203
ChainResidue
AGLU8
AASP57
AHOH305
AHOH314
AHOH327

site_idAC4
Number of Residues4
Detailsbinding site for residue CA A 204
ChainResidue
AGLU18
AASP29
AHOH321
AHOH324

site_idAC5
Number of Residues5
Detailsbinding site for residue CA A 205
ChainResidue
ALYS127
AASP128
AGLU130
ALYS133
AHOH326

Functional Information from PROSITE/UniProt
site_idPS00387
Number of Residues7
DetailsPPASE Inorganic pyrophosphatase signature. DGDPLDA
ChainResidueDetails
AASP52-ALA58

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor => ECO:0000305|PubMed:26296329
ChainResidueDetails
AASP89

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000305|PubMed:26296329
ChainResidueDetails
AGLU8
AASP52
AASP57
AASP84
AASP89

site_idSWS_FT_FI3
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:26296329
ChainResidueDetails
ALYS16
AARG30
ATYR42
ATYR126

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PDB entries from 2024-11-13

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