4Z69

Human serum albumin complexed with palmitic acid and diclofenac

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0005504	molecular_function	fatty acid binding
A	0005507	molecular_function	copper ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005794	cellular_component	Golgi apparatus
A	0008289	molecular_function	lipid binding
A	0009267	biological_process	cellular response to starvation
A	0015643	molecular_function	toxic substance binding
A	0016209	molecular_function	antioxidant activity
A	0019825	molecular_function	oxygen binding
A	0030170	molecular_function	pyridoxal phosphate binding
A	0031093	cellular_component	platelet alpha granule lumen
A	0031667	biological_process	response to nutrient levels
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0046872	molecular_function	metal ion binding
A	0051087	molecular_function	protein-folding chaperone binding
A	0051902	biological_process	negative regulation of mitochondrial depolarization
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0072732	biological_process	cellular response to calcium ion starvation
A	0098869	biological_process	cellular oxidant detoxification
A	0140272	molecular_function	exogenous protein binding
A	1903981	molecular_function	enterobactin binding
I	0003677	molecular_function	DNA binding
I	0005504	molecular_function	fatty acid binding
I	0005507	molecular_function	copper ion binding
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005783	cellular_component	endoplasmic reticulum
I	0005788	cellular_component	endoplasmic reticulum lumen
I	0005794	cellular_component	Golgi apparatus
I	0008289	molecular_function	lipid binding
I	0009267	biological_process	cellular response to starvation
I	0015643	molecular_function	toxic substance binding
I	0016209	molecular_function	antioxidant activity
I	0019825	molecular_function	oxygen binding
I	0030170	molecular_function	pyridoxal phosphate binding
I	0031093	cellular_component	platelet alpha granule lumen
I	0031667	biological_process	response to nutrient levels
I	0032991	cellular_component	protein-containing complex
I	0042802	molecular_function	identical protein binding
I	0046872	molecular_function	metal ion binding
I	0051087	molecular_function	protein-folding chaperone binding
I	0051902	biological_process	negative regulation of mitochondrial depolarization
I	0070062	cellular_component	extracellular exosome
I	0072562	cellular_component	blood microparticle
I	0072732	biological_process	cellular response to calcium ion starvation
I	0098869	biological_process	cellular oxidant detoxification
I	0140272	molecular_function	exogenous protein binding
I	1903981	molecular_function	enterobactin binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue F15 A 1001

Chain	Residue
A	ARG117
A	TYR138
A	TYR161
A	DIF1006
A	HOH1131

---

site_id	AC2
Number of Residues	7
Details	binding site for residue PLM A 1002

Chain	Residue
A	ALA258
A	SER287
A	HOH1148
A	LEU66
A	PHE70
A	TYR150
A	ARG257

---

site_id	AC3
Number of Residues	7
Details	binding site for residue F15 A 1003

Chain	Residue
A	SER342
A	VAL344
A	ARG348
A	LEU387
A	LEU453
A	ARG485
A	PLM1004

---

site_id	AC4
Number of Residues	5
Details	binding site for residue PLM A 1004

Chain	Residue
A	TYR411
A	LEU460
A	PHE488
A	SER489
A	F151003

---

site_id	AC5
Number of Residues	7
Details	binding site for residue F15 A 1005

Chain	Residue
A	TYR401
A	LYS525
A	HIS535
A	MET548
A	PHE551
A	ALA552
A	SER579

---

site_id	AC6
Number of Residues	10
Details	binding site for residue DIF A 1006

Chain	Residue
A	ILE142
A	HIS146
A	PHE149
A	LEU154
A	TYR161
A	ARG186
A	GLY189
A	LYS190
A	F151001
A	HOH1175

---

site_id	AC7
Number of Residues	8
Details	binding site for residue DIF A 1007

Chain	Residue
A	LYS199
A	TRP214
A	ARG218
A	LEU219
A	ARG222
A	ILE264
A	SER287
A	HOH1146

---

site_id	AC8
Number of Residues	11
Details	binding site for residue DIF A 1008

Chain	Residue
A	LYS199
A	SER202
A	LEU203
A	PHE206
A	ALA210
A	PHE211
A	TRP214
A	VAL344
A	SER480
A	LEU481
A	VAL482

---

site_id	AC9
Number of Residues	3
Details	binding site for residue F15 I 1001

Chain	Residue
I	TYR138
I	TYR161
I	HOH1150

---

site_id	AD1
Number of Residues	8
Details	binding site for residue PLM I 1002

Chain	Residue
I	VAL46
I	PHE70
I	TYR150
I	ALA254
I	ARG257
I	LEU283
I	LEU284
I	SER287

---

site_id	AD2
Number of Residues	6
Details	binding site for residue F15 I 1003

Chain	Residue
I	SER342
I	VAL344
I	ARG348
I	LEU387
I	LEU453
I	ARG485

---

site_id	AD3
Number of Residues	6
Details	binding site for residue PLM I 1004

Chain	Residue
I	LEU387
I	TYR411
I	LEU457
I	LEU460
I	PHE488
I	SER489

---

site_id	AD4
Number of Residues	4
Details	binding site for residue F15 I 1005

Chain	Residue
I	TYR401
I	LYS525
I	HIS535
I	PHE551

---

site_id	AD5
Number of Residues	8
Details	binding site for residue DIF I 1006

Chain	Residue
I	LYS199
I	TRP214
I	ARG218
I	ARG222
I	PHE223
I	ARG257
I	LEU260
I	ALA291

---

Functional Information from PROSITE/UniProt

site_id	PS00212
Number of Residues	25
Details	ALBUMIN_1 Albumin domain signature. YkaafteCCqaAdkaaCLlpkldeL

Chain	Residue	Details
A	TYR161-LEU185
A	TYR353-PHE377
A	PHE551-LEU575

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	384
Details	Domain: {"description":"Albumin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	394
Details	Domain: {"description":"Albumin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00769","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02770","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P02769","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"28567254","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IJF","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"656055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	74
Details	Site: {"description":"Not glycated","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Site: {"description":"Aspirin-acetylated lysine"}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18318008","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by FAM20C","evidences":[{"source":"PubMed","id":"26091039","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	8
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07724","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI17
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI18
Number of Residues	2
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"24129315","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI20
Number of Residues	26
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI21
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6853480","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI23
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Redhill","featureId":"CAR_000226"}

Chain

Residue

Details

---

site_id	SWS_FT_FI24
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; in variant Casebrook","featureId":"CAR_000069"}

Chain

Residue

Details

---

site_id	SWS_FT_FI25
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine","evidences":[{"source":"PubMed","id":"15047055","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6706980","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6853480","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI26
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; alternate","evidences":[{"source":"PubMed","id":"3759977","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---