4Z41

X-ray structure of the adduct formed in the reaction between lysozyme and a platinum(II) Compound with a S,O Bidentate Ligand (9a=Chloro-(1-(3'-hydroxy)-3-(methylthio)-3-thioxo-prop-1-en-1-olate-O,S)-(dimethylsulfoxide-S)-platinum(II))

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003796	molecular_function	lysozyme activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0016231	molecular_function	beta-N-acetylglucosaminidase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0016998	biological_process	cell wall macromolecule catabolic process
A	0031640	biological_process	killing of cells of another organism
A	0042742	biological_process	defense response to bacterium
A	0042802	molecular_function	identical protein binding
A	0050829	biological_process	defense response to Gram-negative bacterium
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0051672	biological_process	obsolete catabolism by organism of cell wall peptidoglycan in other organism

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue 4KV A 201

Chain	Residue
A	CYS6
A	ARG14
A	HIS15
A	THR89
A	VAL92
A	ASN93
A	LYS96
A	ARG128
A	HOH305

---

site_id	AC2
Number of Residues	2
Details	binding site for residue DMS A 202

Chain	Residue
A	TRP62
A	LEU75

---

site_id	AC3
Number of Residues	9
Details	binding site for residue NO3 A 203

Chain	Residue
A	CYS64
A	ASN65
A	ASP66
A	GLY67
A	ARG68
A	THR69
A	SER72
A	HOH302
A	HOH304

---

site_id	AC4
Number of Residues	7
Details	binding site for residue NO3 A 204

Chain	Residue
A	GLY22
A	SER24
A	ASN27
A	PHE34
A	ARG114
A	VAL120
A	EDO211

---

site_id	AC5
Number of Residues	7
Details	binding site for residue NO3 A 205

Chain	Residue
A	PHE3
A	ARG14
A	HIS15
A	SER86
A	ASP87
A	ILE88
A	HOH316

---

site_id	AC6
Number of Residues	6
Details	binding site for residue NO3 A 206

Chain	Residue
A	ARG5
A	LYS33
A	PHE38
A	EDO208
A	HOH356
A	HOH371

---

site_id	AC7
Number of Residues	5
Details	binding site for residue NO3 A 207

Chain	Residue
A	ASN65
A	ASN74
A	ASN77
A	ILE78
A	PRO79

---

site_id	AC8
Number of Residues	3
Details	binding site for residue EDO A 208

Chain	Residue
A	ARG5
A	ALA122
A	NO3206

---

site_id	AC9
Number of Residues	6
Details	binding site for residue EDO A 209

Chain	Residue
A	GLN57
A	ILE58
A	ASN59
A	ALA107
A	TRP108
A	HOH321

---

site_id	AD1
Number of Residues	5
Details	binding site for residue EDO A 210

Chain	Residue
A	THR43
A	THR43
A	THR51
A	ARG68
A	ARG68

---

site_id	AD2
Number of Residues	10
Details	binding site for residue EDO A 211

Chain	Residue
A	ASN27
A	TRP111
A	ARG114
A	CYS115
A	GLY117
A	THR118
A	VAL120
A	NO3204
A	HOH314
A	HOH319

---

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO A 212

Chain	Residue
A	ARG61
A	TRP62
A	GLY71
A	ARG73
A	HOH309

---

site_id	AD4
Number of Residues	5
Details	binding site for residue NO3 A 213

Chain	Residue
A	ALA10
A	ALA10
A	ARG14
A	ARG14
A	LEU129

---

Functional Information from PROSITE/UniProt

site_id	PS00128
Number of Residues	19
Details	GLYCOSYL_HYDROL_F22_1 Glycosyl hydrolases family 22 (GH22) domain signature. CnipCsaLlssDItasvnC

Chain	Residue	Details
A	CYS76-CYS94

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE:

Chain	Residue	Details
A	GLU35
A	ASP52

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING:

Chain	Residue	Details
A	ASP101

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	6
Details	M-CSA 203

Chain	Residue	Details
A	GLU35	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor
A	ASN46
A	ASP48
A	SER50
A	ASP52	covalently attached, electrostatic stabiliser, nucleofuge, nucleophile, polar/non-polar interaction
A	ASN59

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