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4Z1Q

Crystal structure of the first bromodomain of human BRD4 bound to benzotriazolo-diazepine scaffold

Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue 558 A 201
ChainResidue
ATRP81
APRO82
ALEU92
ATYR139
AASN140
AILE146
AHOH318

site_idAC2
Number of Residues10
Detailsbinding site for residue 558 B 201
ChainResidue
AASP145
BPRO82
BPHE83
BLEU92
BTYR139
BASN140
BILE146
BHOH318
AHIS77
APHE79

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140
BASN140

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
BLYS99
ALYS99

219869

PDB entries from 2024-05-15

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