4YZF

Crystal structure of the anion exchanger domain of human erythrocyte Band 3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005452	molecular_function	solute:inorganic anion antiporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006820	biological_process	monoatomic anion transport
A	0006821	biological_process	chloride transport
A	0006873	biological_process	intracellular monoatomic ion homeostasis
A	0007596	biological_process	blood coagulation
A	0008509	molecular_function	monoatomic anion transmembrane transporter activity
A	0009898	cellular_component	cytoplasmic side of plasma membrane
A	0015075	molecular_function	monoatomic ion transmembrane transporter activity
A	0015106	molecular_function	bicarbonate transmembrane transporter activity
A	0015108	molecular_function	chloride transmembrane transporter activity
A	0015297	molecular_function	antiporter activity
A	0015701	biological_process	bicarbonate transport
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0017121	biological_process	plasma membrane phospholipid scrambling
A	0030018	cellular_component	Z disc
A	0030492	molecular_function	hemoglobin binding
A	0030506	molecular_function	ankyrin binding
A	0030863	cellular_component	cortical cytoskeleton
A	0035811	biological_process	negative regulation of urine volume
A	0042803	molecular_function	protein homodimerization activity
A	0043495	molecular_function	protein-membrane adaptor activity
A	0045852	biological_process	pH elevation
A	0048821	biological_process	erythrocyte development
A	0051453	biological_process	regulation of intracellular pH
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0072562	cellular_component	blood microparticle
A	0072659	biological_process	protein localization to plasma membrane
A	0098660	biological_process	inorganic ion transmembrane transport
A	0140900	molecular_function	chloride:bicarbonate antiporter activity
A	0170014	cellular_component	ankyrin-1 complex
A	1902476	biological_process	chloride transmembrane transport
A	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
B	0005452	molecular_function	solute:inorganic anion antiporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006820	biological_process	monoatomic anion transport
B	0006821	biological_process	chloride transport
B	0006873	biological_process	intracellular monoatomic ion homeostasis
B	0007596	biological_process	blood coagulation
B	0008509	molecular_function	monoatomic anion transmembrane transporter activity
B	0009898	cellular_component	cytoplasmic side of plasma membrane
B	0015075	molecular_function	monoatomic ion transmembrane transporter activity
B	0015106	molecular_function	bicarbonate transmembrane transporter activity
B	0015108	molecular_function	chloride transmembrane transporter activity
B	0015297	molecular_function	antiporter activity
B	0015701	biological_process	bicarbonate transport
B	0016020	cellular_component	membrane
B	0016323	cellular_component	basolateral plasma membrane
B	0017121	biological_process	plasma membrane phospholipid scrambling
B	0030018	cellular_component	Z disc
B	0030492	molecular_function	hemoglobin binding
B	0030506	molecular_function	ankyrin binding
B	0030863	cellular_component	cortical cytoskeleton
B	0035811	biological_process	negative regulation of urine volume
B	0042803	molecular_function	protein homodimerization activity
B	0043495	molecular_function	protein-membrane adaptor activity
B	0045852	biological_process	pH elevation
B	0048821	biological_process	erythrocyte development
B	0051453	biological_process	regulation of intracellular pH
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0072562	cellular_component	blood microparticle
B	0072659	biological_process	protein localization to plasma membrane
B	0098660	biological_process	inorganic ion transmembrane transport
B	0140900	molecular_function	chloride:bicarbonate antiporter activity
B	0170014	cellular_component	ankyrin-1 complex
B	1902476	biological_process	chloride transmembrane transport
B	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
C	0005452	molecular_function	solute:inorganic anion antiporter activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006820	biological_process	monoatomic anion transport
C	0006821	biological_process	chloride transport
C	0006873	biological_process	intracellular monoatomic ion homeostasis
C	0007596	biological_process	blood coagulation
C	0008509	molecular_function	monoatomic anion transmembrane transporter activity
C	0009898	cellular_component	cytoplasmic side of plasma membrane
C	0015075	molecular_function	monoatomic ion transmembrane transporter activity
C	0015106	molecular_function	bicarbonate transmembrane transporter activity
C	0015108	molecular_function	chloride transmembrane transporter activity
C	0015297	molecular_function	antiporter activity
C	0015701	biological_process	bicarbonate transport
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0017121	biological_process	plasma membrane phospholipid scrambling
C	0030018	cellular_component	Z disc
C	0030492	molecular_function	hemoglobin binding
C	0030506	molecular_function	ankyrin binding
C	0030863	cellular_component	cortical cytoskeleton
C	0035811	biological_process	negative regulation of urine volume
C	0042803	molecular_function	protein homodimerization activity
C	0043495	molecular_function	protein-membrane adaptor activity
C	0045852	biological_process	pH elevation
C	0048821	biological_process	erythrocyte development
C	0051453	biological_process	regulation of intracellular pH
C	0055085	biological_process	transmembrane transport
C	0070062	cellular_component	extracellular exosome
C	0072562	cellular_component	blood microparticle
C	0072659	biological_process	protein localization to plasma membrane
C	0098660	biological_process	inorganic ion transmembrane transport
C	0140900	molecular_function	chloride:bicarbonate antiporter activity
C	0170014	cellular_component	ankyrin-1 complex
C	1902476	biological_process	chloride transmembrane transport
C	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate
D	0005452	molecular_function	solute:inorganic anion antiporter activity
D	0005515	molecular_function	protein binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006820	biological_process	monoatomic anion transport
D	0006821	biological_process	chloride transport
D	0006873	biological_process	intracellular monoatomic ion homeostasis
D	0007596	biological_process	blood coagulation
D	0008509	molecular_function	monoatomic anion transmembrane transporter activity
D	0009898	cellular_component	cytoplasmic side of plasma membrane
D	0015075	molecular_function	monoatomic ion transmembrane transporter activity
D	0015106	molecular_function	bicarbonate transmembrane transporter activity
D	0015108	molecular_function	chloride transmembrane transporter activity
D	0015297	molecular_function	antiporter activity
D	0015701	biological_process	bicarbonate transport
D	0016020	cellular_component	membrane
D	0016323	cellular_component	basolateral plasma membrane
D	0017121	biological_process	plasma membrane phospholipid scrambling
D	0030018	cellular_component	Z disc
D	0030492	molecular_function	hemoglobin binding
D	0030506	molecular_function	ankyrin binding
D	0030863	cellular_component	cortical cytoskeleton
D	0035811	biological_process	negative regulation of urine volume
D	0042803	molecular_function	protein homodimerization activity
D	0043495	molecular_function	protein-membrane adaptor activity
D	0045852	biological_process	pH elevation
D	0048821	biological_process	erythrocyte development
D	0051453	biological_process	regulation of intracellular pH
D	0055085	biological_process	transmembrane transport
D	0070062	cellular_component	extracellular exosome
D	0072562	cellular_component	blood microparticle
D	0072659	biological_process	protein localization to plasma membrane
D	0098660	biological_process	inorganic ion transmembrane transport
D	0140900	molecular_function	chloride:bicarbonate antiporter activity
D	0170014	cellular_component	ankyrin-1 complex
D	1902476	biological_process	chloride transmembrane transport
D	1904539	biological_process	negative regulation of glycolytic process through fructose-6-phosphate

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue 4KU A 1000

Chain	Residue
A	PRO419
A	PRO467
A	PHE532
A	GLU535
A	LYS539
A	GLU681
A	LYS851

---

site_id	AC2
Number of Residues	7
Details	binding site for residue 4KU B 1000

Chain	Residue
B	PHE532
B	GLU535
B	LYS539
B	PHE792
B	LYS851
B	THR422
B	PRO467

---

site_id	AC3
Number of Residues	8
Details	binding site for residue 4KU C 1000

Chain	Residue
C	PRO419
C	THR422
C	PRO467
C	PHE532
C	GLU535
C	LYS539
C	PHE792
C	LYS851

---

site_id	AC4
Number of Residues	14
Details	binding site for Di-peptide 4KU D 1000 and LYS D 851

Chain	Residue
D	PRO419
D	THR422
D	PRO467
D	ILE531
D	PHE532
D	GLU535
D	LYS539
D	LEU847
D	VAL849
D	VAL850
D	SER852
D	THR853
D	SER856
D	LEU859

---

site_id	AC5
Number of Residues	14
Details	binding site for Di-peptide 4KU D 1000 and LYS D 539

Chain	Residue
D	PRO419
D	THR422
D	PRO467
D	PHE532
D	GLU535
D	THR536
D	PHE537
D	SER538
D	LEU540
D	ILE541
D	LYS542
D	ILE543
D	PHE789
D	LYS851

---

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
F	TYR196-HIS202

---

site_id	PS00219
Number of Residues	12
Details	ANION_EXCHANGER_1 Anion exchangers family signature 1. FGGLVRDIRRRY

Chain	Residue	Details
A	PHE379-TYR390

---

site_id	PS00220
Number of Residues	15
Details	ANION_EXCHANGER_2 Anion exchangers family signature 2. FLISLIFIYETFsKL

Chain	Residue	Details
A	PHE526-LEU540

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2160
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	MET1-PRO403
B	GLN457-LEU459
B	PHE507-ARG518
B	LYS592-ARG602
B	THR685-SER700
B	LEU738-ARG760
B	SER801-GLY838
B	ARG870-VAL911
C	MET1-PRO403
C	GLN457-LEU459
C	PHE507-ARG518
A	GLN457-LEU459
C	LYS592-ARG602
C	THR685-SER700
C	LEU738-ARG760
C	SER801-GLY838
C	ARG870-VAL911
D	MET1-PRO403
D	GLN457-LEU459
D	PHE507-ARG518
D	LYS592-ARG602
D	THR685-SER700
A	PHE507-ARG518
D	LEU738-ARG760
D	SER801-GLY838
D	ARG870-VAL911
A	LYS592-ARG602
A	THR685-SER700
A	LEU738-ARG760
A	SER801-GLY838
A	ARG870-VAL911
B	MET1-PRO403

---

site_id	SWS_FT_FI2
Number of Residues	92
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	GLN404-LEU427
B	GLN404-LEU427
C	GLN404-LEU427
D	GLN404-LEU427

---

site_id	SWS_FT_FI3
Number of Residues	328
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	GLY428-MET435
C	SER477-GLU485
C	LYS542-THR570
C	ILE624-MET663
D	GLY428-MET435
D	SER477-GLU485
D	LYS542-THR570
D	ILE624-MET663
A	SER477-GLU485
A	LYS542-THR570
A	ILE624-MET663
B	GLY428-MET435
B	SER477-GLU485
B	LYS542-THR570
B	ILE624-MET663
C	GLY428-MET435

---

site_id	SWS_FT_FI4
Number of Residues	80
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	GLY436-ALA456
B	GLY436-ALA456
C	GLY436-ALA456
D	GLY436-ALA456

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	TRANSMEM: Discontinuously helical; Name=3 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	LEU460-PHE476
B	LEU460-PHE476
C	LEU460-PHE476
D	LEU460-PHE476

---

site_id	SWS_FT_FI6
Number of Residues	80
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	TYR486-ALA506
B	TYR486-ALA506
C	TYR486-ALA506
D	TYR486-ALA506

---

site_id	SWS_FT_FI7
Number of Residues	88
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	TYR519-ILE541
B	TYR519-ILE541
C	TYR519-ILE541
D	TYR519-ILE541

---

site_id	SWS_FT_FI8
Number of Residues	80
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	ALA571-PHE591
B	ALA571-PHE591
C	ALA571-PHE591
D	ALA571-PHE591

---

site_id	SWS_FT_FI9
Number of Residues	80
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	ARG603-PHE623
B	ARG603-PHE623
C	ARG603-PHE623
D	ARG603-PHE623

---

site_id	SWS_FT_FI10
Number of Residues	80
Details	TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	MET664-ILE684
B	MET664-ILE684
C	MET664-ILE684
D	MET664-ILE684

---

site_id	SWS_FT_FI11
Number of Residues	72
Details	TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	GLY701-PHE719
B	GLY701-PHE719
C	GLY701-PHE719
D	GLY701-PHE719

---

site_id	SWS_FT_FI12
Number of Residues	68
Details	TRANSMEM: Discontinuously helical; Name=10 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	GLY720-ALA737
B	GLY720-ALA737
C	GLY720-ALA737
D	GLY720-ALA737

---

site_id	SWS_FT_FI13
Number of Residues	80
Details	TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	ILE761-SER781
B	ILE761-SER781
C	ILE761-SER781
D	ILE761-SER781

---

site_id	SWS_FT_FI14
Number of Residues	72
Details	TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	ARG782-LEU800
B	ARG782-LEU800
C	ARG782-LEU800
D	ARG782-LEU800

---

site_id	SWS_FT_FI15
Number of Residues	120
Details	INTRAMEM: Discontinuously helical => ECO:0000269|PubMed:26542571

Chain	Residue	Details
A	ILE839-LEU869
B	ILE839-LEU869
C	ILE839-LEU869
D	ILE839-LEU869

---

site_id	SWS_FT_FI16
Number of Residues	4
Details	SITE: Important for anion transport

Chain	Residue	Details
A	LYS590
B	LYS590
C	LYS590
D	LYS590

---

site_id	SWS_FT_FI17
Number of Residues	4
Details	SITE: Important for anion-proton cotransport

Chain	Residue	Details
A	GLU681
B	GLU681
C	GLU681
D	GLU681

---

site_id	SWS_FT_FI18
Number of Residues	4
Details	MOD_RES: N-acetylmethionine => ECO:0000269|PubMed:2790053, ECO:0000269|PubMed:701248

Chain	Residue	Details
A	MET1
B	MET1
C	MET1
D	MET1

---

site_id	SWS_FT_FI19
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405, ECO:0000269|PubMed:1998697

Chain	Residue	Details
A	TYR8
A	TYR21
B	TYR8
B	TYR21
C	TYR8
C	TYR21
D	TYR8
D	TYR21

---

site_id	SWS_FT_FI20
Number of Residues	4
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:1998697

Chain	Residue	Details
A	TYR46
B	TYR46
C	TYR46
D	TYR46

---

site_id	SWS_FT_FI21
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P23562

Chain	Residue	Details
A	SER185
B	SER185
C	SER185
D	SER185

---

site_id	SWS_FT_FI22
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P04919

Chain	Residue	Details
A	SER350
B	SER350
C	SER350
D	SER350

---

site_id	SWS_FT_FI23
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:10942405

Chain	Residue	Details
A	TYR359
A	TYR904
B	TYR359
B	TYR904
C	TYR359
C	TYR904
D	TYR359
D	TYR904

---

site_id	SWS_FT_FI24
Number of Residues	4
Details	LIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:1885574

Chain	Residue	Details
A	CYS843
B	CYS843
C	CYS843
D	CYS843

---

site_id	SWS_FT_FI25
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:10861210, ECO:0000269|PubMed:24121512, ECO:0000269|PubMed:35835865

Chain	Residue	Details
A	ASN642
B	ASN642
C	ASN642
D	ASN642

---