4YZ3
Crystal Structure of Streptococcus pneumoniae NanC, in complex with Oseltamivir.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0006689 | biological_process | ganglioside catabolic process |
| A | 0009313 | biological_process | oligosaccharide catabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
| B | 0004308 | molecular_function | exo-alpha-sialidase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0006689 | biological_process | ganglioside catabolic process |
| B | 0009313 | biological_process | oligosaccharide catabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016798 | molecular_function | hydrolase activity, acting on glycosyl bonds |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue G39 A 1001 |
| Chain | Residue |
| A | ARG290 |
| A | TRP716 |
| A | ARG309 |
| A | ASP315 |
| A | ASP372 |
| A | TYR553 |
| A | SER582 |
| A | ARG600 |
| A | ARG662 |
| A | TYR695 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 A 1002 |
| Chain | Residue |
| A | ARG360 |
| A | ASN509 |
| A | ASP510 |
| A | SER514 |
| A | ASN719 |
| A | HOH1132 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 1003 |
| Chain | Residue |
| A | TYR181 |
| A | LYS182 |
| A | HIS275 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 A 1004 |
| Chain | Residue |
| A | TYR460 |
| A | HIS485 |
| A | HIS664 |
| A | HOH1287 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1005 |
| Chain | Residue |
| A | ASP422 |
| A | THR423 |
| A | ASP424 |
| A | ASN426 |
| A | ARG439 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 1006 |
| Chain | Residue |
| A | THR241 |
| A | ALA242 |
| A | PHE243 |
| B | ASN441 |
| B | ARG442 |
| site_id | AC7 |
| Number of Residues | 12 |
| Details | binding site for residue G39 B 1001 |
| Chain | Residue |
| B | ARG290 |
| B | ASP315 |
| B | ILE371 |
| B | ASP372 |
| B | ASP388 |
| B | TYR553 |
| B | SER582 |
| B | ARG600 |
| B | ARG662 |
| B | TYR695 |
| B | TRP716 |
| B | HOH1135 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1002 |
| Chain | Residue |
| B | ARG360 |
| B | ASN509 |
| B | ASN719 |
| B | HOH1260 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1003 |
| Chain | Residue |
| B | TYR181 |
| B | LYS182 |
| B | HIS275 |
| B | HOH1361 |
| site_id | AD1 |
| Number of Residues | 4 |
| Details | binding site for residue SO4 B 1004 |
| Chain | Residue |
| B | TYR460 |
| B | HIS485 |
| B | HIS664 |
| B | HOH1305 |
| site_id | AD2 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 1005 |
| Chain | Residue |
| B | ASP422 |
| B | THR423 |
| B | ASP424 |
| B | ASN426 |
| B | HOH1269 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 1006 |
| Chain | Residue |
| A | ASN441 |
| B | THR241 |
| B | ALA242 |
| B | PHE243 |
| B | GLY244 |
