4YYY
X-ray structure of the thymidine phosphorylase from Salmonella typhimurium in complex with uridine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| A | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| A | 0009032 | molecular_function | thymidine phosphorylase activity |
| A | 0016154 | molecular_function | pyrimidine-nucleoside phosphorylase activity |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0046104 | biological_process | thymidine metabolic process |
| B | 0004645 | molecular_function | 1,4-alpha-oligoglucan phosphorylase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0006206 | biological_process | pyrimidine nucleobase metabolic process |
| B | 0006213 | biological_process | pyrimidine nucleoside metabolic process |
| B | 0009032 | molecular_function | thymidine phosphorylase activity |
| B | 0016154 | molecular_function | pyrimidine-nucleoside phosphorylase activity |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0046104 | biological_process | thymidine metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue CIT A 501 |
| Chain | Residue |
| A | LYS84 |
| A | HIS85 |
| A | SER86 |
| A | SER95 |
| A | SER113 |
| A | THR123 |
| A | LYS191 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | binding site for residue CIT A 502 |
| Chain | Residue |
| A | SER186 |
| A | ILE187 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue PGE A 503 |
| Chain | Residue |
| A | TYR267 |
| A | ASP385 |
| A | THR439 |
| A | GLU440 |
| site_id | AC4 |
| Number of Residues | 9 |
| Details | binding site for residue URI B 501 |
| Chain | Residue |
| B | THR87 |
| B | LEU117 |
| B | GLY118 |
| B | TYR168 |
| B | ARG171 |
| B | ILE183 |
| B | SER186 |
| B | ILE187 |
| B | LYS190 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue URI B 502 |
| Chain | Residue |
| A | LYS291 |
| B | SER248 |
| B | GLN261 |
| B | TYR267 |
| site_id | AC6 |
| Number of Residues | 9 |
| Details | binding site for residue CIT B 503 |
| Chain | Residue |
| B | LYS84 |
| B | HIS85 |
| B | SER86 |
| B | SER95 |
| B | ILE112 |
| B | SER113 |
| B | GLY114 |
| B | THR123 |
| B | LYS191 |
Functional Information from PROSITE/UniProt
| site_id | PS00647 |
| Number of Residues | 16 |
| Details | THYMID_PHOSPHORYLASE Thymidine and pyrimidine-nucleoside phosphorylases signature. SGRGLghTGGTlDkLE |
| Chain | Residue | Details |
| A | SER113-GLU128 |
