4YXQ

PksG, a HMG-CoA Synthase from Bacillus subtilis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
A	0005737	cellular_component	cytoplasm
A	0006084	biological_process	acetyl-CoA metabolic process
A	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
A	0016740	molecular_function	transferase activity
A	0016746	molecular_function	acyltransferase activity
A	0017000	biological_process	antibiotic biosynthetic process
B	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
B	0005737	cellular_component	cytoplasm
B	0006084	biological_process	acetyl-CoA metabolic process
B	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
B	0016740	molecular_function	transferase activity
B	0016746	molecular_function	acyltransferase activity
B	0017000	biological_process	antibiotic biosynthetic process
C	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
C	0005737	cellular_component	cytoplasm
C	0006084	biological_process	acetyl-CoA metabolic process
C	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
C	0016740	molecular_function	transferase activity
C	0016746	molecular_function	acyltransferase activity
C	0017000	biological_process	antibiotic biosynthetic process
D	0004421	molecular_function	hydroxymethylglutaryl-CoA synthase activity
D	0005737	cellular_component	cytoplasm
D	0006084	biological_process	acetyl-CoA metabolic process
D	0010142	biological_process	farnesyl diphosphate biosynthetic process, mevalonate pathway
D	0016740	molecular_function	transferase activity
D	0016746	molecular_function	acyltransferase activity
D	0017000	biological_process	antibiotic biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue PEG B 501

Chain	Residue
B	GLN245
B	ARG320

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site_id	AC2
Number of Residues	2
Details	binding site for residue PEG D 501

Chain	Residue
D	VAL235
D	ARG320

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site_id	AC3
Number of Residues	2
Details	binding site for residue PEG D 502

Chain	Residue
D	GLN245
D	ARG320

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton donor/acceptor => ECO:0000250

Chain	Residue	Details
A	GLU82
A	HIS250
B	GLU82
B	HIS250
C	GLU82
C	HIS250
D	GLU82
D	HIS250

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site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Acyl-thioester intermediate => ECO:0000250

Chain	Residue	Details
A	CYS114
B	CYS114
C	CYS114
D	CYS114

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